Uterine primitive neuroectodermal tumor: a case report

Çelik, Hüsnü; Gürateş, Bilgin; Karaoğlu, Aziz; Yavuz, Adem; Dagli, Ferda; Ozercan, Resat

doi:10.1007/s00404-008-0699-z

Cited by 11 publications

(4 citation statements)

References 10 publications

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“…The uterine corpus is the next common site, while the cervix and the vulva are rarely the primary site [4]. There are 43 cases of uterine PNETs reported in the literature to date [2-6]. …”

Section: Discussionmentioning

confidence: 99%

Uterine primitive neuroectodermal tumor with adenosarcoma: a case report

et al. 2010

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IntroductionPrimitive neuroectodermal tumor of the uterus is extremely rare. They occur as either pure primitive neuroectodermal tumors or admixed with neoplasms of mullerian origin.Case presentationA case of uterine primitive neuroectodermal tumor with adenosarcoma in a 50-year-old Asian Indian woman is presented. Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes. A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative. Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.ConclusionTo the best of our knowledge, this report represents the second case of a uterine primitive neuroectodermal tumor with an admixed adenosarcoma.

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“…The uterine corpus is the next common site, while the cervix and the vulva are rarely the primary site [4]. There are 43 cases of uterine PNETs reported in the literature to date [2-6]. …”

Section: Discussionmentioning

confidence: 99%

Uterine primitive neuroectodermal tumor with adenosarcoma: a case report

et al. 2010

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“…Reports with incomplete information about chemotherapy were also excluded. Of a total of 178 papers identified from the search terms in the MEDLINE database, 49 cases fulfilled the mentioned criteria (Table ). We analyzed the choice of chemotherapy regimen in relation to the patients’ ages and divided patients into the following groups: adolescence (<20 years), reproductive (20–40 years), premenopausal (40–60 years) and elderly (>60 years).…”

Section: Discussionmentioning

confidence: 99%

Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review

Akazawa

Saito

Ariyoshi

et al. 2018

J of Obstet and Gynaecol

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A primitive neuroectodermal tumor (PENT) belongs to the category of a Ewing sarcoma. A PENT of the uterus is rare and has been known to be very aggressive by nature. Owing to the rarity of the tumor, there is no optimal treatment at present. In many cases, after hysterectomy, chemotherapy or radiation therapy has been performed. However, an effective chemotherapy regimen was unclear. In the soft tissue sarcoma area, the chemotherapy approach has recently greatly improved. Vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VDC-IE) therapy has improved the survival rate of patients with Ewing sarcoma/PENT. Thus, VDC-IE therapy may be used for a uterine PENT. Here, we report a case of a uterine PENT in a premenopausal woman successfully treated with multimodality treatment including VDC-IE therapy and discuss the optimal chemotherapy for a uterine PENT through a literature review.

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“…Patients mostly present with abnormal vaginal bleeding or postmenapousal bleeding, like in our cases. However, atypic presentations such as uterine rupture have also been reported ( 4 ) . Some of the uterine PNETs are associated with other tumor components such as endometrioid adenocarcinoma, carcinosarcoma, unclassified sarcoma, rhabdomyosarcoma, and adenosarcoma ( 3 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Our cases were not associated with other tumor components but 15 cases with other associated uterine pathologies were reported in the last review article ( 2 ) . There are different ideas regarding the origin of this tumor in the uterus ( 4 ) . These include prior implantation of fetal tissue, neo-metaplasia, malignant mixed Müllerian tumor with one-sided differentiation.…”

Section: Discussionmentioning

confidence: 99%

Primitive uterine neuroectodermal tumours: Two case reports

Eskiyörük

Güleç

Paydaş

et al. 2015

tjod

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Primitive neuroectodermal tumor (PNET) arise from Kulchitsky cells and are rarely seen in the female genital tract. Differential diagnosis of PNET can be made based on immunohistochemical profiles and genetic analyses. Genital tract pNETs are very aggressive pathologies with different clinical and molecular manifestations and there are no standard guidelines for treatment. We aimed to present two cases of uterine PNETs with different symptomatology and clinical findings.

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Uterine primitive neuroectodermal tumor: a case report

Abstract: To the best of our knowledge, this is first report of uterine PNET that presented with intraabdominal hemorrhage due to uterine rupture. Despite advances in therapy, the prognosis is poor. The low number of these cases precludes accurate standardization of therapy.

Cited by 11 publications

References 10 publications

Uterine primitive neuroectodermal tumor with adenosarcoma: a case report

Uterine primitive neuroectodermal tumor with adenosarcoma: a case report

Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review

Primitive uterine neuroectodermal tumours: Two case reports

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