Uterine Prolapse: From Antiquity to Today

Downing, Keith

doi:10.1155/2012/649459

Cited by 27 publications

(11 citation statements)

References 54 publications

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“…The field of urogynecology has recently been steeped in controversy surrounding the use of transvaginal mesh implants for POP or urinary incontinence surgery. Meshaugmented repair using polypropylene was initially introduced on the basis of the success of polypropylene mesh in the correction of incisional hernias, with the idea that POP is a type of hernia comparable with other fascial defects [2]. The successful use of polypropylene midurethral slings for urinary stress incontinence was a contributing factor to the idea of using mesh-augmented repair in POP surgery.…”

Section: Introductionmentioning

confidence: 99%

The international discussion and the new regulations concerning transvaginal mesh implants in pelvic organ prolapse surgery

et al. 2020

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The use of transvaginal mesh implants for POP and urinary incontinence is currently being extensively debated among experts as well as the general public. Regulations surrounding the use of these implants differ depending on the country. Although in the USA, the UK, in Canada, Australia, New Zealand, and France, transvaginal mesh implants have been removed from the market, in most mainland European countries, Asia, and South America, they are still available as a surgical option for POP correction. The aim of this review is to provide an overview of the historical timeline and the current situation worldwide, as well as to critically discuss the implications of the latest developments in urogynecological patient care and the training of doctors.

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Section: Introductionmentioning

confidence: 99%

The international discussion and the new regulations concerning transvaginal mesh implants in pelvic organ prolapse surgery

et al. 2020

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“…4 This mode of treatment was first described by Soranus who first used a woollen tampon dipped in vinegar to reduce the prolapse. 7 Wood apple is indigenous in south East Asian countries and few decades ago it was commonly used to treat uterine prolapse in rural parts of India. However this practice is obsolete with the advent of safe anaesthetic and surgical techniques.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of long standing vaginal foreign body removed with obstetric forceps

Padmalata

Fathima

2015

Int J Reprod Contracept Obstet Gynecol

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“…Our understanding of the pathophysiology of POP and progress in its management has developed slowly over time [18]. Over the last decade, a number of studies have drawn an association between vaginal parity and pelvic floor disorders (PFDs) including POP [5][6][7]19,20].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy with and without birth trauma modulates the gene expression of proteins involved in elastic fiber homeostasis in the rat vagina

Downing¹,

Strube²,

Mikhail³

et al. 2013

OJOG

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Objectives: Elastic fibers have been linked to the pathogenesis of pelvic organ prolapse. This study used a rat model to examine the effect of mode of delivery on the gene expression of proteins involved in elastic fiber homeostasis. Methods: 38 Sprague-Dawley rats were separated as follows: virgin rats after simulated vaginal delivery, groups A (n = 5) and B (n = 5); pregnant rats after spontaneous vaginal delivery, groups C (n = 5) and D (n = 5); pregnant rats after cesarean delivery, groups E (n = 6) and F (n = 5). Groups A, C and E were sacrificed 2 days after the intervention, groups B, D and F were sacrificed 14 days after the intervention. 7 virgin rats served as controls. Vaginal tissue was harvested for RNA extraction and cDNA conversion. The mRNA expression for lysyl oxidase like 1 (LOXL-1), tropoelastin and fibulin 5 (FBLN 5) was quantified via real-time reverse transcriptase polymerase chain reaction using the 2 −ΔΔCt method; β-actin was selected as the reference gene. Results: Postpartum day two we observed an up-regulation in the relative mRNA expression of LOXL-1, FBLN 5 and Tropoelastin in all groups compared to controls. In lower vaginal tissue the up-regulation decreased uniformly from postpartum day two to postpartum day fourteen. However, the relative mRNA expression of the target genes in upper vaginal tissue persisted at postpartum day fourteen in the SpVD and CD cohort. Conclusions: Vaginal trauma, whether as a result of spontaneous vaginal delivery or simulated vaginal delivery, resulted in the upregulation of genes involved in elastic fiber homeostasis. In addition, pregnancy and parturition, in the absence of direct vaginal trauma, also resulted in the upregulation of these genes. Our findings leave open the possibility that alterations in elastic fiber homeostasis occurring during pregnancy, regardless of mode of delivery, may play a role in the pathogenesis of POP.

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Uterine Prolapse: From Antiquity to Today

Cited by 27 publications

References 54 publications

The international discussion and the new regulations concerning transvaginal mesh implants in pelvic organ prolapse surgery

The international discussion and the new regulations concerning transvaginal mesh implants in pelvic organ prolapse surgery

An unusual case of long standing vaginal foreign body removed with obstetric forceps

Pregnancy with and without birth trauma modulates the gene expression of proteins involved in elastic fiber homeostasis in the rat vagina

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