Uterine Receptivity and Endometrial Secretory Protein Patterns

Beier-Hellwig, K.; Bonn, B.; Sterzik, K.; Linder, Dietmar; Muller, Sylviane; Bygdeman, M.; Beier, Henning M.

doi:10.1007/978-1-4612-2548-5_6

Cited by 10 publications

(1 citation statement)

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“…166,167 With the advent of specific monoclonal and polyclonal antibodies, and immunohistochemical methods as well as microarray technology, there are now a greatly expanded number of biomarkers to investigate. 34,163,[168][169][170][171][172][173][174] Integrins and Cell Adhesion Molecules Dynamic changes in integrin expression during the menstrual cycle provide the opportunity to examine the functional quality of the endometrium during the time of peak P secretion. 91,92 Integrins are arguably the best characterized markers of P effect on the endometrium.…”

Section: Biomarkers Of Progesterone Actionmentioning

confidence: 99%

Progesterone Function in Human Endometrium: Clinical Perspectives

Young

Lessey

2010

Semin Reprod Med

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Progesterone is essential for endometrial receptivity and successful establishment of pregnancy. Either an insufficient progesterone concentration or an insufficient response to progesterone, therefore can lead to infertility and pregnancy loss. Assessment of the role that either progesterone insufficiency or inadequate progesterone response plays in human reproductive failure has been difficult to assess because serum progesterone concentrations fluctuate markedly, limiting the ability to characterize sufficiency of progesterone, and there are no highly reliable markers of endometrial function available. Recent evidence demonstrates exquisite sensitivity of normal endometrium to very low levels of progesterone stimulation, suggesting that progesterone insufficiency should not be a common cause of reproductive failure. Further evidence suggests that women with endometriosis, and possibly polycystic ovarian syndrome, have an altered progesterone response, which may explain some of the clinical features of these disorders and supports the hypothesis that progesterone resistance underlies some cases of human reproductive failure.

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