Uterine relaxant effects of Curcuma aeruginosa Roxb. rhizome extracts

Thaina, P.; Tungcharoen, Pattreeya; Wongnawa, Malinee; Reanmongkol, Wantana; Subhadhirasakul, Sanan

doi:10.1016/j.jep.2008.10.022

Cited by 48 publications

(42 citation statements)

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“…[66,72,73] Many steroids, tannins, alkaloids, and flavonoid compounds have also been reported from the rhizomes of C. pseudomontana and bioactive sesquiterpenes compounds such as germacrone, zederone, dehydrocurdione, curcumenol, zedoarondiol, and isocurcumenol along with β-pinene or other sesquiterpene lactones have been shown to be responsible for the antiandrogenic effect and uterine relaxant property of C. aeruginosa. [13,68,74] According to Mujumdar et al, [75] the ethyl alcohol extracts of C. amada rhizomes contain compounds with hydroxyl, ester, carbonyl, and olefin functional groups, which contributed to the anti-inflammatory activity of the extracts in acute and chronic administration in albino rats. Further pharmacological researches in the plant has also reported the presence of other compounds like arturmerone, difurocumenonol, and amadannulen to be responsible for the antiplatelet property, antioxidant and antimicrobial activities.…”

Section: Curcuma Zanthorrhizamentioning

confidence: 99%

“…Biological activities Curcuma aeruginosa Antimicrobial [164] , cytotoxicity [152] ; antinociceptive, antipyretic [13] ; uterine relaxant [74] ; antioxidant [165] ; inhibition of nitric oxide production [166] ; and anti-inflammatory [153] Curcuma amada Antifungal and insecticidal [79] ; CNS depressant and analgesic [16,167] ; antiulcer [168] ; anti-tubercular [135] ; antioxidant, antimicrobial, cytotoxic and antiplatelet [20] ; anti-inflammatory [169] ; anticancer [170] ; and larvicidal [171] Curcuma angustifolia Antimicrobial, antiulcerogenic [172,173] ; antioxidant [155] ; antifungal and antibacterial [129] Curcuma aromatica Hypoglycemic [172] ; anti-Alzheimer [173] ; antioxidant [2] ; cytotoxicity [174] ; insecticidal [175] ; antiinflammatory [169] ; antibacterial [11] ; inhibition of nitric oxide production [176] ; antiproliferative [177] ; and gastroprotective [21] Curcuma australasica Inhibition of nitric oxide and prostaglandin production, anti-inflammatory, and cytotoxic [115] Curcuma caesia Smooth muscle relaxant [178] ; anxiolytic, CNS depressant and neuropharmacological [179,180] ; antimicrobial [151] ; antiulcerogenic [181] ; antitumor and antioxidant [116] ; anticancer [182] ; antihepatotoxicity and nephrotoxicity [...…”

Section: Plant Speciesmentioning

confidence: 99%

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Nutritional value, phytochemical composition, and biological activities of edibleCurcumaspecies: A review

Rajkumari

Sanatombi

2017

International Journal of Food Properties

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Plants belonging to the genus Curcuma are gaining importance globally as one of the significant ingredients in food and traditional medicines. Apart from being considered as nutritionally rich food products, interest in medicinal properties of Curcuma species has increased due to the discovery of novel bioactive compounds possessing wide bioactivities such as antioxidant, antiviral, antimicrobial, and anti-inflammation activities. This article summarizes the literature pertaining to the nutritional values, bioactive compounds, as well as the biological activities of 16 edible Curcuma species. Additionally, the bioavailability, cytotoxicity, and allied health benefits of these species are also discussed and highlighted. The brief information provided in this review will open future perspectives for investigations related to their possible use as functional foods and in pharmaceutical applications. ARTICLE HISTORY

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Section: Curcuma Zanthorrhizamentioning

confidence: 99%

Section: Plant Speciesmentioning

confidence: 99%

Nutritional value, phytochemical composition, and biological activities of edibleCurcumaspecies: A review

Rajkumari

Sanatombi

2017

International Journal of Food Properties

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“…Both tissues contain OT receptors (OTRs). The number of these receptors is increased by estrogen and decreased by progesterone 5 . OT is secreted from granulosa cells in cattle is estradiol-dependent and is involved in growth, maturation and ovulation of follicles 6 .…”

Section: öZetmentioning

confidence: 99%

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mentioning

confidence: 99%

PCB-153 İle İnkübe Edilen Sığır Miyometriumu Üzerine Diklofenak Potasyum ve Diklofenak Sodyumun Tokolitik Etkisi

Daş¹,

Aksoy²,

Yavuz³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryIn this study, the tocolytic effects of the potassium and sodium salts of diclofenac, a non-steroidal anti-inflammatory drug (NSAID), on cattle myometria were investigated in the presence of an estrogenic polychlorinated biphenyl congener 2,2 ' ,4,4' ,5,. The uterine samples were obtained from newly slaughtered, non-pregnant cattle more than two years old and in the anoestrus stage. Eight groups were constituted for testing (each group contained 8 strips from two animals, with 4 from each); there were four control groups (diclofenac potassium 24 h and 48 h; diclofenac sodium 24 h and 48 h) and four groups for PCB-153 (diclofenac potassium 24 h and 48 h; diclofenac sodium 24 h and 48 h). The control groups were incubated in physiological salt solution (PSS) for 24 or 48 hours and the PCB-153 groups were incubated in PSS which contained 100 ng/mL of PCB-153, for either 24 h or 48 h. After the incubation period, the strips were hung and incubated in the tissue bath system until spontaneous contractions occurred. Oxytocin (OT) was administered at 0.5 nM to the strips in all groups for the stimulation of spontaneous contractions. Diclofenac potassium and diclofenac sodium were then administered cumulatively in the range of 1x10 -7 to 7x10 -4 M to the strips of all groups to the maximum inhibitory effect was observed. After each application, isometric uterine contractions were recorded for 20 min. Mean peak amplitude (P MAX ), frequency (beats per minutes, BPM) and area under the curve (AUC) values of the myometrial contractions, which are criteria for determining drug effects, were calculated from the curve and evaluated statistically. The inhibitory concentration 50 (IC 50 ) values were calculated for the BPM, P MAX and AUC values of the myometrial contractions. Finally, the tocolytic effects of diclofenac potassium and diclofenac sodium on the contractions of cattle uterine strips pre-incubated with PCB-153, were determined. Keywords: Diclofenac potassium, Diclofenac sodium, PCB-153, Cattle, Tocolysis PCB-153 İle İnkübe Edilen Sığır Miyometriumu Üzerine Diklofenak Potasyum ve Diklofenak Sodyumun Tokolitik Etkisi ÖzetBu çalışmada, steroid yapıda olmayan ağrı kesici ve yangı giderici ilaçlardan (non steroidal anti-inflammatory drugs, NSAIDs) diklofenakın potasyum ve sodyum tuzlarının poliklorlu bifenil (PCB)'lerden östrojenik etkili 2,2' ,4,4' ,5,5'-hekzaklorobifenil (PCB-153) varlığında sığır uterus düz kaslarını gevşetici etkisi araştırılmıştır. Uterus örnekleri mezbahada iki yaşın üzerinde, yeni kesilen, anöstrüs evresinde, gebe olmayan ineklerden sağlanmıştır. İlaçların etkisini ortaya koymak için, dört kontrol (diklofenak potasyum 24 ve 48 saat, diklofenak sodyum 24 ve 48 saat) ve dört PCB-153 (diklofenak potasyum 24 ve 48 saat, diklofenak sodyum 24 ve 48 saat) olmak üzere sekiz ayrı grup oluşturulmuştur. Her bir grup iki farklı hayvandan dörder olmak üzere toplam sekiz miyometrium şeridi içermektedir. Kontrol grupları ayrı ayrı 24 ve 48 saat süre ile fizyolojik tuz solüsyonu (physiological salt saline, P...

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“…Many plants have been recently investigated world-wide in the search for tocolytic or uterus-relaxing agent such as Curcuma aeruginosa Roxb. Rhizome (Thaina, 2009), Scutellaria baicalensis root (Shih et al, 2009) and Ficus capensis Thunb (Owolab et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Uterus-Relaxing Study of a Sudanese Herb (El-Hazha)

Ahmed¹

2010

American Journal of Biochemistry and Biotechnology

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Problem statement:The aim of this study is to investigate the pharmacological effects of the Methanolic-extract (AH2) of El-Hazha and its sub-fractions. Approach: These investigations were carried out on in vitro isolated uterus preparations from Non-Pregnant (NP) and Late-Pregnant rats (LP). In parallel displacement radio-ligand binding assay was performed for β-Adrenergic Receptors (β-ADR). Results: Showed that the herb and its different fractions produced dose-dependent relaxant effect (p<0.05, t-test, n = 6) on uterine contraction elicit by 25 mM KCl in both NP and LP uteri that affected significantly by fractionation, however, the effect of the most active fraction (AH2-11) was reversed by prior addition of propranolol (non-specific β-antagonist), but not affected by progesterone pre treatment of the LP rats. In addition, AH2 only in high concentration displaced isotopes from β-ADR, this affinity changed markedly by fractionation. Conclusion: We validate the fractionation effect on its relaxant activity and found partial role for β-ADR on mediating this activity. Future study was recommended to isolate and investigate its active components to enhance this activity or to discover a new novel natural therapeutic agent(s).

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Uterine relaxant effects of Curcuma aeruginosa Roxb. rhizome extracts

Cited by 48 publications

References 35 publications

Nutritional value, phytochemical composition, and biological activities of edibleCurcumaspecies: A review

Nutritional value, phytochemical composition, and biological activities of edibleCurcumaspecies: A review

PCB-153 İle İnkübe Edilen Sığır Miyometriumu Üzerine Diklofenak Potasyum ve Diklofenak Sodyumun Tokolitik Etkisi

Uterus-Relaxing Study of a Sudanese Herb (El-Hazha)

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