Uterine sarcoma: An unusual but high lethal disease of gynecological malignancies

Comparing paclitaxel-platinum with ifosfamide-platinum as the front-line chemotherapy for patients with advanced-stage uterine carcinosarcoma

“…4–6 In the past and traditionally, uterine CS (UCS) has been regarded as a subtype of uterine sarcomas and is often analyzed after grouping other uterine sarcomas, such as undifferentiated uterine sarcoma, endometrial stromal sarcoma, and leiomyosarcoma. 7–10 Recently, clinical, pathologic, and biological evidence has indicated that UCS is a monoclonal origin, which is derived from the Müllerian duct and closely related to high-grade endometrial carcinoma with the driving force to result in sarcomatous transformation (metaplastic carcinoma), and subsequently form the homologous or heterologous groups, depending on the characteristics of the stroma or mesenchymal components of endometrial tissues. 11–13…”

“…[4][5][6] In the past and traditionally, uterine CS (UCS) has been regarded as a subtype of uterine sarcomas and is often analyzed after grouping other uterine sarcomas, such as undifferentiated uterine sarcoma, endometrial stromal sarcoma, and leiomyosarcoma. [7][8][9][10] Recently, clinical, pathologic, and biological evidence has indicated that UCS is a monoclonal origin, which is derived from the Müllerian duct and closely related to high-grade endometrial carcinoma with the driving force to result in sarcomatous transformation (metaplastic carcinoma), and subsequently form the homologous or heterologous groups, depending on the characteristics of the stroma or mesenchymal components of endometrial tissues. [11][12][13] Primary complete surgical staging or primary cytoreductive surgery (PCS) is a key factor in the management of women with UCS, based on the studies obtained from the experience for high-grade or advanced endometrial cancer and uterine sarcomas as well as epithelial ovarian cancer, primary peritoneal serous carcinoma, and primary fallopian tube cancers.…”