Uterine secretory activity and histology of prepubertal female dogs in an animal model of partial ablation of endometrial glands development

Martins, Bianca B.; Teixeira, Natália Soares; Teixeira, Stéphanie Asséf Millen Valente; Giannotti, J.; Nunes, Lélia Cápua; Freitas, P. M. C.; Machado‐Neves, Mariana; Luz, Marcelo Rezende

doi:10.1590/1678-5150-pvb-6361

Cited by 1 publication

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, previous literature suggests that the development of EPs has a positive association with CEH/pyometra complex, which is thought to be related to exposure of the uterine tissues to sex hormones (i.e., oestrogen and progesterone), infection, irritant and low-grade or subclinical endometritis. 2,4,5,[17][18][19] Two mechanisms of the pathogenesis of CEH/pyometra complex have been proposed. 6,16 The first suggests that endometrial hyperplasia (with or without cyst formation) develops after cumulative exposure of the uterine tissues to oestrogen and progesterone, thus resulting in accumulation of secretion, followed by predisposition to ascending bacterial infection.…”

Section: Discussionmentioning

confidence: 99%

“…The specific aetiology of EP remains unknown. However, previous literature suggests that the development of EPs has a positive association with CEH/pyometra complex, which is thought to be related to exposure of the uterine tissues to sex hormones (i.e., oestrogen and progesterone), infection, irritant and low‐grade or subclinical endometritis 2,4,5,17–19 . Two mechanisms of the pathogenesis of CEH/pyometra complex have been proposed 6,16 .…”

Section: Discussionmentioning

confidence: 99%

“…The alternative hypothesis is that a low‐grade uterine infection can be partially responsible for endometrial proliferation that occurs in the early pathogenesis of CEH/pyometra complex. Multiple studies 17,19–21 demonstrate that progesterone plays an important role in the development and maintenance of CEH by causing endometrial glandular proliferation and secretion. However, controversy remains that endometrial hyperplasia is mediated through modified progesterone receptors rather than an increased serum progesterone level 6,18,22,23 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Endometrial polyp in a spayed female dog

Lai,

Jenkins,

Sumner

et al. 2023

Vet Record Case Reports

View full text Add to dashboard Cite

Endometrial polyps are rare benign uterine masses exclusively reported in geriatric, entire, female dogs or spayed female dogs with ovarian remnant syndrome. A 12‐year‐old, female, ovariohysterectomised cocker spaniel was presented for hyporexia, progressive muco‐haemorrhagic vulval discharge, and an ultrasonographically detected caudal abdominal mass. Thoracic and abdominal computed tomography revealed that the mass originated from the uterine stump, with no evidence of metastasis. Surgical excision of the mass was performed, and histopathology of the mass was consistent with an endometrial polyp. The dog was confirmed to be neutered based on the absence of ovarian remnant found on computed tomography and during surgery, and the negative results of both anti‐Mullerian hormone test and human chorionic gonadotropin stimulated progesterone test. The dog fully recovered with complete resolution of clinical signs at 2‐week, 6‐month and 18‐month rechecks. The presenting case highlights the first reported case of an endometrial polyp in a spayed female dog.

show abstract