Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules

Kotsopoulos, Ioannis C; Barbetakis, Nikolaos; Asteriou, Christos; Voutsas, Markos G

doi:10.4103/0971-5851.103148

Cited by 19 publications

(11 citation statements)

References 3 publications

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“…Therefore, counseling and follow-up strategies for patient with this disease remain undetermined. STUMPs are usually clinically benign but in some cases, recurrence can occur many years following surgery (both conservative and aggressive) ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential

et al. 2016

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Uterine smooth muscle tumors are the most common female genital tract neoplasms. While leiomyosarcoma has been studied at length, smooth muscle tumors of uncertain malignant potential (STUMPs) still have ambiguous and unresolved issues, with a risk of relapse and evolution largely undefined. We performed an array comparative genomic hybridization analysis on a primitive STUMP and its local recurrence, histologically diagnosed as undifferentiated sarcoma. To the best of our knowledge, our report is the first genomic study on primitive STUMPs and the different relapsed tumors. The results showed few copy number alterations shared between both samples and the high heterogeneity in the STUMP was apparently lost in the sarcoma. Surprisingly the STUMP presented an amplification of the BCL2 gene, not observed in the relapsed tumor. Additionally, fluorescence in situ hybridization and immunohistochemical staining were performed to confirm BCL2 amplification and expression in these samples and in two other cases of primitive STUMPs and their corresponding relapsed tumors. The presence of BCL2 in multiple copies and expression in the two primitive STUMPs and two relapsed tumors was confirmed. The marked amplification of the BCL2 gene present in the primitive STUMP and the multiple copies also observed in other cases, suggest its potential role as a marker of STUMP malignant potential and recurrence.

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Section: Introductionmentioning

confidence: 99%

Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential

et al. 2016

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“…Suspecter le diagnostic cliniquement ou radiologiquement reste difficile vu que les STUMP ne présentent pas de caractères spécifiques comparés au léiomyome bénin. Néanmoins pour la recherche de métastases, l'étage thoraco-abdomino-pelvien doit être systématique vu que des cas de métastases notamment pulmonaire suite à des STUMP ont été rapportés dans la littérature [3, 4]. En revanche, il n'y a pas de données précises sur le caractère métastatique des STUMP.…”

Section: Discussionunclassified

“…En revanche, il n'y a pas de données précises sur le caractère métastatique des STUMP. Dans notre cas, jusqu'à présent une seule TDM TAP a été réalisée n'objectivant aucune localisation secondaire [3]. Cette incertitude dans le diagnostic anatomo-pathologique mène fréquemment à des dilemmes thérapeutiques, particulièrement lorsque le diagnostic est établi à partir de prélèvements de myomectomie issus des femmes qui souhaitent maintenir et/ou améliorer leur fertilité.…”

Section: Discussionunclassified

Fibrome utérin associé à un STUMP (tumeurs musculaires lisse de malignité incertaine): à propos d'un cas

Saoud¹,

Benchiba²,

Mamouni³

et al. 2018

Pan Afr Med J

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Les tumeurs musculaires lisses à potentiel de malignité incertain (STUMP) sont des tumeurs musculaires lisses dont les caractéristiques morphologiques ne permettent pas de les ranger de façon formelle en tumeur bénigne ou maligne. Nous rapportons ici le cas d'une patiente âgée de 44 ans sans antécédents pathologiques notables qui consulte pour une augmentation du volume abdominal. Une échographie pelvienne et une TDM TAP ont été réalisées objectivant une énorme masse à double composante tissulaire et liquidienne au dépend de l'utérus. La patiente a bénéficié d'une laparotomie exploratrice avec découverte de deux masses, une au dépend de l'utérus et l'autre en rétropéritonéal. Le résultat anatomo-pathologique était en faveur d'un myome utérin associé à un STUMP.

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“…Smooth muscle tumours of uncertain malignant potential (STUMP) are mesenchymal uterine tumours with a malignant potential found somewhere between that of benign leiomyomas and leiomyosarcomas [1] . Only three cases of STUMP pulmonary metastasis exist in the literature.…”

Section: Introductionmentioning

confidence: 99%

A large and late mediastinal metastasis from a uterine smooth muscle tumour of uncertain malignant potential: A case report

Ciarrocchi

Aramini

Sanna

et al. 2022

International Journal of Surgery Case Reports

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Introduction Smooth muscle tumours of uncertain malignant potential (STUMP) are mesenchymal uterine tumours with a malignant potential found somewhere between that of benign leiomyomas and leiomyosarcomas. Only three cases of STUMP pulmonary metastasis exist in the literature. Case presentation We report the case of a 63 year-old female patient presenting with dysphonia secondary to recurrent laryngeal nerve paralysis due to an enormous mediastinal STUMP metastasis, 14 years after having undergone a total hysterectomy with bilateral salpingo-oophorectomy. A successful left pneumonectomy was performed and the mass weighing 1570 g was histologically confirmed as a STUMP metastasis. Discussion Only three cases of pulmonary metastasis from STUMP have been reported in the recent literature and no robust information exists about the metastatic nature of STUMP. No cases exist in the literature of a successful pneumonectomy performed for a STUMP metastasis of such large dimensions presenting after many years from the diagnosis of the primary uterine lesion. Physicians should keep in mind that the finding of a smooth muscle tumour in the lung of a woman should promptly raise the suspicion of a metastatic uterine malignancy, even several years after diagnosis of the primary lesion. Conclusion Despite the size, invasiveness and late presentation of the STUMP metastasis, the surgery was successful and the patient no longer requires oxygen therapy.

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Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules

Cited by 19 publications

References 3 publications

Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential

Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential

Fibrome utérin associé à un STUMP (tumeurs musculaires lisse de malignité incertaine): à propos d'un cas

A large and late mediastinal metastasis from a uterine smooth muscle tumour of uncertain malignant potential: A case report

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