Uterine smooth muscle tumors of uncertain malignant potential (STUMP): management, follow up and prognosis

Conte, Alpha Boubacar; Elhaoudani, Jebryl; Yessoufou, Mahomed Ilyas; Chaara, Hikmat; Melhouf, Moulay Abdelilah

doi:10.11604/pamj-cm.2020.3.82.22506

Cited by 7 publications

(7 citation statements)

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“…The definition given by the WHO (2020) for STUMP describes smooth muscle tumors whose microscopic characteristics indicate potential for malignancy, but which do not meet the diagnostic criteria for either leiomyoma or leiomyosarcoma [ 8 ]. These represent 1.3% of all uterine malignant neoplasms [ 13 ]. They are diagnosed more frequently in premenopausal women, with an average age of 44 years [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

Boşoteanu

Deacu

Aşchie

et al. 2023

JCM

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Myocytic tumors of the uterus present vast morphological heterogeneity, which makes differential diagnosis between the different entities necessary. This study aims to enrich the existing data and highlight new potential therapeutic targets regarding aspects related to the pathogenic process and the tumor microenvironment in order to improve the quality of life of women. We performed a 5-year retrospective study, including particular cases of uterine myocyte tumors. Immunohistochemical analyses of pathogenic pathways (p53, RB1, and PTEN) and tumor microclimate using markers (CD8, PD-L1, and CD105), as well as genetic testing of the PTEN gene, were performed. The data were statistically analyzed using the appropriate parameters. In cases of atypical leiomyoma, a significant association was observed between PTEN deletion and an increased number of PD-L1+ T lymphocytes. For malignant lesions and STUMP, PTEN deletion was associated with the advanced disease stage. Advanced cases were also associated with an increased mean CD8+ T cell count. An increased number of lymphocytes was associated with an increased percentage of RB1+ nuclei. The study corroborated clinical and histogenetic data, highlighting the importance of the differential diagnosis of these tumors to improve the management of patients and increase their quality of life.

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Section: Discussionmentioning

confidence: 99%

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

Boşoteanu

Deacu

Aşchie

et al. 2023

JCM

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Section: Discussionmentioning

confidence: 99%

“…STUMP tumors are characterized by clinical and histological heterogeneity [ 12 ]. They have a frequency of approximately 0.01%, their prevalence being difficult to assess due to their rarity and variable/subjective diagnostic criteria [ 12 , 13 ]. The incidence of uterine leiomyosarcoma is between 0.35–0.8/100,000, with a prevalence of 3–7/100,000 [ 14 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical manifestations of STUMP are nonspecific, being frequently similar to those of leiomyomas—namely metrorrhagia, pelvic mass, and pelvic pain—but also secondary symptoms of compression phenomena or anemia [ 12 ]. Regarding leiomyosarcomas, the clinical manifestations at the time of diagnosis are represented by metrorrhagia (56%), palpable pelvic mass (54%), abdominal pain (22%), but also abnormal vaginal secretions, pollakiuria, constipation, and abdominal distension [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

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Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma

Boşoteanu

Deacu

Vodă

et al. 2022

Clinics and Practice

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Taking into account the unpredictable evolution of uterine STUMP and leiomyosarcomas, there are no clearly established therapeutic protocols to date, the only certified treatment being total hysterectomy. We performed a 5-year retrospective study including cases of malignant tumors and those with uncertain malignant potential originating in the smooth muscle tissue of the uterine body. The clinical data, pathological aspects, and the immunohistochemical results were statistically analyzed using SPSS Statistics Version 26. The main associations of the p53 gene were identified with age, atypia, and the occurrence of metastases. The average number of CD8+ T cells correlated with the hormonal status of the patients, the presence of diabetes, and alteration of thyroid function, but also with the severity of the atypia. The therapeutic method was represented by total hysterectomy, and 30% of the patients with leiomyosarcoma also benefited from adjuvant chemotherapy. The average period until death was 25.66 months. The present study showed that the mutant expression of p53 could have a role in assessing the clinical evolution of patients, given the association with exitus and metastasis. In addition, the average number of CD8+ T cells corresponded to severe atypia, indicating the possibility of applying targeted immunotherapies in these cases.

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“…The clinical manifestations of STUMP are non-specific, frequently similar to those of leiomyomas - namely metrorrhagia, pelvic mass and pelvic pain - but also secondary symptoms of compression phenomena or anaemia [ 8 ]. In our study, the main clinical manifestation was post-menopausal metrorrhagia.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Uterine smooth muscle tumor of uncertain malignant potential (STUMP) ABOUT a CASE

Amal,

Fadwa,

Aicha

et al. 2024

International Journal of Surgery Case Reports

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Uterine smooth muscle tumors of uncertain malignant potential (STUMP): management, follow up and prognosis

Cited by 7 publications

References 0 publications

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma

Uterine smooth muscle tumor of uncertain malignant potential (STUMP) ABOUT a CASE

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