Utero-ovarian relationships in placental mammals : role of uterus and embryo in the regulation of progesterone secretion by the corpus luteum. A review

Levasseur, Marie-Claire

doi:10.1051/rnd:19830601

Cited by 22 publications

(5 citation statements)

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“…A compromised intrauterine environment can result from either maternal or fetal disorders. Changes primarily manifest in the form of either hypoxia, infection or an imbalance of in utero development (Levasseur 1983, Reef et al 1995.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and hematological biomarkers of reproductive failure in bottlenose dolphins Tursiops truncatus

et al. 2021

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The physiological demands of pregnancy inevitably result in alterations in both biochemical and hematological parameters as fetal development occurs. The shifts observed in successful pregnancy in bottlenose dolphins Tursiops truncatus to support both fetal physiological needs and maternal basal requirements have been established according to each trimester. Detecting aberrations in blood-based biomarkers could help facilitate diagnosis of gestational abnormalities, improve our understanding of factors influencing reproductive outcomes and aid in prediction of reproductive failure. This study retrospectively analyzed 263 blood samples from 15 bottlenose dolphins in 21 failed pregnancies over 28 yr (1989-2017). Most samples remained within normal pregnancy reference ranges; however, significant shifts were observed between trimesters. Hematological alterations, compared to successful pregnancy reference ranges from previously published data, were consistent across failed pregnancies and included an increased prevalence of elevated 2nd and 3rd trimester neutrophils, elevated 2nd trimester monocytes and decreased 3rd trimester eosinophils. In addition, low hematocrit and low red blood cells were more prevalent in the 2nd trimester. Biochemical shifts included an increased prevalence of elevated creatine phosphokinase in the 3rd trimester outside of the normal reference ranges. Across failed pregnancies, calcium and iron were decreased in the 3rd trimester. Significantly decreased progesterone in the 3rd trimester was a negative prognostic indicator of pregnancy outcome with decreasing 3rd trimester progesterone associated with failed pregnancy. This study demonstrates the use of blood-based biomarkers as possible predictors of pregnancy outcome in bottlenose dolphins.

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Section: Discussionmentioning

confidence: 99%

Biochemical and hematological biomarkers of reproductive failure in bottlenose dolphins Tursiops truncatus

et al. 2021

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“…It is well documented that prostaglandin F2a of uterine origin is the luteolytic agent responsible for regression of the corpus luteum in the cow, sow, mare and sheep (9). In the dog, however, it has been demonstrated that the uterus is not involved in the regulation of the cyclic corpus luteum (13,14).…”

Section: Introductionmentioning

confidence: 99%

Evidence for prolactin as the main luteotrophic factor in the cyclic dog

Okkens

Bevers

Dieleman

et al. 1990

Veterinary Quarterly

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SUMMARY The role of prolactin and LH in the control of the function of the corpus luteum in the dog was studied. Experiments were performed to interfere with the secretion of a) prolactin by administering a dopamine agonist and b) LH by desensitisation with a long-acting LHRH and by stimulation. Treatments with prolactin-lowering dosages of bromocriptine, (20 pg/kg body weight twice a day, orally; n = 8) which started between day 1-5 (n = 4) and day 20-24 (n = 4) of the luteal period resulted in a similar pattern of progesterone concentration in peripheral blood in both groups. The progesterone release in the second half of the luteal period (13. I ± 1.8% (sem) of the progesterone release of the total luteal period) was significantly lower than in control dogs (24.7 ± 2.2%). Treatment at about day 30 of the luteal period with LHRH CR (1.34 mg, intramuscularly; n = 3), which significantly suppressed the LH level, did not reduce the progesterone release in the second half of the luteal period, 21.3 ± 4.7% compared to 24.7 ± 2.2% in the control dogs. The endogenous LH peak resulting from treatment with LHRH had no effect on the progesterone concentration in the blood. It is concluded that prolactin is the main luteotrophic factor in the cyclic dog during the second half of the luteal period.

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“…This transfer has been shown to exist for several hormones in cattle (6, 8, 11, 14, 15, 28). In this connection the lymphatics of the plica urogenitalis must be kept in mind (6,8,9,11,17).…”

Section: Discussionmentioning

confidence: 99%

Alkaline Phosphatase Activities and Progesterone Concentrations in Uterine Flushings of Dairy Cows: Side‐Effects and Variations During Oestrous Cycle

Wittkowski

Boos

Ehlers

et al. 1989

Journal of Veterinary Medicine Series A

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Summary After evisceration at an abattoir, both uterine horns of barren cows were flushed using 30 ml of Dulbecco's phosphate buffered saline (trial 1, 49 cows) or 10 ml sterile saline (0.9%, trial 2, 22 cows). Blood was collected from the animals' hearts (trial 2). Activities of alkaline phosphatase and progesterone concentrations (trial 2) were determined in uterine flushings and serum. In uterine flushings, both parameters exhibited a significant cyclic pattern, while in serum, only progesterone concentrations showed cyclic fluctuations. Alkaline phosphatase activities in uterine flushings taken ipsilateral to a corpus luteum were significantly higher than in materials obtained from the contralateral horn during dioestrus and prooestrus. A similar tendency was obvious for progesterone concentrations. All parameters but serum alkaline phosphatase activity were positively correlated with each other. The results suggest a close relationship between a progesterone secreting corpus luteum and metabolic as well as hormonal parameters evaluated in flushings of the ipsilaterally situated uterine horn. Transfer of progesterone via the blood vessels and lymphatics within the ligamentum latum uteri may be the cause of the between‐side‐effects detected. Zusammenfassung Aktivität der Alkalischen Phosphatase und Progesteronkonzentration in uterinen Spülmedien von Milchkühen Einfluß der Seite und Veränderungen während des Brunstzyklus: Nach der Eviszeration am Schlachthof wurden beide Uterushörner von nicht tragenden Schlachtkühen mit 30 ml Dulbecco's phosphatgepufferter physiologischer Kochsalzlösung (Versuch 1, 49 Tiere) oder mit 10 ml steriler physiologischer Kochsalzlösung (Versuch 2, 22 Tiere) separat gespült. Blut wurde anläßlich der Eröffnung des Herzens gewonnen (Versuch 2). In den uterinen Spülmedien und im Serum wurden die Aktivität der alkalischen Phosphatase und die Progesteronkonzentration (Versuch 2) bestimmt. Beide Parameter zeigten in uterinen Spülmedien signifikante Veränderungen, die vom Zyklusstadium abhingen. Im Serum war dies nur für die Progesteronkonzentration der Fall. Die Aktivität der alkalischen Phosphatase in uterinen Spülmedien aus dem ipsilateral zu einem Gelbkörper gelegenen Horn waren signifikant höher als in Spülmedien, die aus dem kontralateral dazu gelegenen Horn gewonnen wurden; dieser Sachverhalt traf sowohl für den Di‐ als auch den Proöstrus zu. ähnliche Tendenzen ließen sich auch für die entsprechenden Progesteronkonzentrationen aufzeigen. Alle erhobenen Parameter — außer der Aktivität der alkalischen Phosphatase im Serum — waren positiv miteinander korreliert. Die Ergebnisse lassen auf eine enge Beziehung zwischen einem progesteronproduzierenden Gelbkörper und den metabolischen sowie den hormonalen Parametern in Spülmedien aus dem ipsilateral dazu befindlichen Uterushorn schließen. Ein Transfer von Progesteron über die Blut‐ und Lymphgefäße innerhalb des Ligamentum latum uteri ist möglicherweise die Ursache für die nachgewiesene Lateralität im bovinen Uterus.

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Utero-ovarian relationships in placental mammals : role of uterus and embryo in the regulation of progesterone secretion by the corpus luteum. A review

Abstract: regulation of luteal progesterone secretion can be grouped according to three major types of uterus-embryo relationships : epitheliochorial, endotheliochorial or hemochorial placentation (see Wimsatt, 1962

Cited by 22 publications

References 149 publications

Biochemical and hematological biomarkers of reproductive failure in bottlenose dolphins Tursiops truncatus

Biochemical and hematological biomarkers of reproductive failure in bottlenose dolphins Tursiops truncatus

Evidence for prolactin as the main luteotrophic factor in the cyclic dog

Alkaline Phosphatase Activities and Progesterone Concentrations in Uterine Flushings of Dairy Cows: Side‐Effects and Variations During Oestrous Cycle

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