Uteroplacental circulation during the first trimester of normal and abnormal pregnancy

Giacobbe, Marcelo; Zeferino, Luíz Carlos; Franzin, C.M.M.O.; Faúndes, Aníbal

doi:10.1016/s1472-6483(10)61917-7

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…In our study, there was a statistically significant difference [P<0.05] when we compare between cases of normal pregnancy [control group] and abnormal pregnancy [study groups] at different gestational ages from [6][7][8][9][10][11][12] as regards uterine artery [RI and PI] indices and this significant difference decrease with advancing gestational age from 6-12 weeks. Giacobbe et al [13] results were more or less similar to our results. They had found that uterine artery pulsatility and resistance indices were decreased with the advance of the gestational age in both controls and missed abortion groups.…”

Section: Discussionsupporting

confidence: 92%

Comparative Study of Color Doppler Imaging in Normal and Abnormal First Trimester Pregnancy

Sileem

Mansour

Aabdelazem

2020

International Journal of Medical Arts

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Background: Color Doppler ultrasonography enables the non-invasive study of physiologic and pathophysiologic changes in the uterine and ovarian circulation in pregnant and non-pregnant women. Aim of the work:To evaluate the potential value of color Doppler of the uterine artery, corpus luteum blood flow, and subchorionic blood vessels in abnormal first-trimester pregnancy. Patients and methods: The study included 200 pregnant women in the first trimester in the antenatal care clinic of the Department of Obstetrics and Gynecology AL Azhar University [Assiut], divided into two groups; control group [100 cases] with normal pregnancy and study group [100 cases] which was further subdivided into threatened abortion [60 cases], blighted ovum [20 cases] and vesicular mole [20 cases]. Results:The uterine artery resistance index [RI] of the study groups was lower than the control group. The decrease was highly significant in the uterine artery RI of both threatened abortion and blighted ovum groups and significant in the vesicular mole group. Uterine artery pulsatility index [PI] showed a significant decrease in the study group compared with the control cases. There was a highly significant negative correlation between gestational age and both RI and PI of the study group's uterine artery. There was a higher prevalence of abortion in a group of threatened abortion compared to the control group. Conclusion:The prevalence of pregnancy complications is increased in association with abnormal blood flow patterns of the early uteroplacental circulation. Doppler indices of the early gestation uteroplacental circulation have an important value in the threatened abortion follow up.

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Section: Discussionsupporting

confidence: 92%

Comparative Study of Color Doppler Imaging in Normal and Abnormal First Trimester Pregnancy

Sileem

Mansour

Aabdelazem

2020

International Journal of Medical Arts

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“…Therefore, fetal blood supply could be worth analyzing to investigate fetal nutrition and growth, especially in IUGR piglets. Previously, uterine blood flow has been measured in pigs during pregnancy by electromagnetic flow transducers [9] and ultrasonic transit time flow probes [10].Noninvasive techniques of Doppler blood flow measurements have been established in human obstetric practice to access fetoplacental and uteroplacental circulation, especially to predict fetal intrauterine growth restriction [11][12][13][14][15]. It was demonstrated that reduced blood flow in the umbilical vessels of human fetuses was related to fetal growth retardation [16,17].…”

mentioning

confidence: 99%

“…Noninvasive techniques of Doppler blood flow measurements have been established in human obstetric practice to access fetoplacental and uteroplacental circulation, especially to predict fetal intrauterine growth restriction [11][12][13][14][15]. It was demonstrated that reduced blood flow in the umbilical vessels of human fetuses was related to fetal growth retardation [16,17].…”

mentioning

confidence: 99%

Laparoscopy Guided Doppler Ultrasound Measurement of Fetal Blood Flow Indices During Early to Mid-Gestation in Pigs

Brüssow

Kurth

Vernunft

et al. 2012

Journal of Reproduction and Development

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Abstract. The objectives of this study were to obtain relevant blood flow indices of umbilical arteries (UmA) of porcine fetuses using a laparoscopic ultrasound probe and to relate these data with fetal size at early to mid gestation. Fetal parameters and flow indices, i.e., fetal length and area, fetal heart rate (FHR), systolic pulse duration (T1), interpulse duration (T2), T2/T1 ratio, peak systolic velocity (PSV), time averaged velocity (TAV), resistance index (RI) and pulsatility index (PI), were measured in 182 fetuses of 26 pregnant Landrace gilts on pregnancy day (PD) 36 (122 fetuses from 17 gilts), PD42 (19 fetuses from 3 gilts) and PD51 (42 fetuses from 6 gilts). Fetal heart rate was higher on PD36 than on PD42 (P<0.05). No differences (P>0.05) were obtained concerning systolic pulse duration, flow velocities and RI. On PD42, the PI was lower (P<0.05), while the interpulse duration (P=0.06) and T2/T1 ratio tended (P=0.08) to be higher on PD42 compared with PD36 and to PD51. To find differences in UmA blood flow parameters concerning fetal size, i.e., fetal length, fetuses were retrospectively grouped as follows: small (lower 25%), medium (mean 50%) and large (upper 25%), respectively. Although, fetuses differed in size (P<0.001) within and between days of pregnancy, FHR, PSV, TAV, RI and PI did not differ (P>0.05) among the size classes. Only systolic pulse duration tended to be longer (P=0.05) in large compared with small fetuses on PD36, and interpulse duration was lower in large fetuses on PD36 in comparison with PD51 (P<0.05). Though there was no link between fetal blood flow indices and fetal intrauterine growth retardation (IUGR), with further studies based on these flow indices, it might be possible to evaluate nutrient-or stress-related influences on fetal growth and development, particularly in the case of IUGR. Key words: Female pig, Fetal blood flow, Laparoscopy, Pregnancy, Ultrasonography (J. Reprod. Dev. 58: [243][244][245][246][247] 2012) T he profitability of pig production considerably depends on the number of live born and fostered piglets. Breeding efforts result nowadays in a greater than before number of piglets. However, pre-and postnatal losses are concomitantly increasing (up to 30%) [1]. Furthermore, intrauterine growth retardation (IUGR), resulting in lighter body weight at birth, is a significant problem in pig production [2]. Lighter birth weight piglets show reduced survival rate, compromised postnatal development [3] as well as decreased carcass and meat quality [4]. Uterine and umbilical blood flows maintain the placental transport and exchange of respiratory gases, nutrients and wastes, and thereby support fetal growth and metabolism [5]. As previously demonstrated in the pig, the blood flow to the fetus was reduced with increasing number of fetuses [6]. Experimental vascular occlusion of the uterine arteries of pigs markedly reduced conceptus development [7]. In utero growth retardation, beside other factors such as uterine capacity and number and position of fetuses ...

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“…If there are any doubts about the failure of the pregnancy, a repeat scan in 7-10 days is necessary for saving both the mother and the obstetrician from unpleasant feelings and situations. 48…”

Section: Discussionmentioning

confidence: 99%

“…Women with missed abortions and nonembryonic gestational sacs frequently showed a facilitated uteroplacental blood flow, as indicated by a higher number of myometrial blood vessels, higher frequency of flow in the intervillous space, and lower vascular impedance, compared with those in normal pregnancies. 48 The indices of impedance to flow decreased with gestation and there was a progressive fall in these indices from the uterine artery, through the radial, to the spiral artery. Blood velocity in the uterine artery increased exponentially with gestation.…”

Section: Early Pregnancy Blood Supply Assessment a N D Safety O F Ultrasoundmentioning

confidence: 97%

Early Pregnancy Scanning: Step-by-Step Overview

Antsaklis¹,

Papamichail²,

Theodora³

2018

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Ultrasound is an essential tool for the evaluation of early pregnancy structures. The main method used during early pregnancy is transvaginal ultrasonography, in order to evaluate the course of the pregnancy during the first weeks. Although our knowledge on ultrasound has increased significantly during the last few years, still early pregnancy remains an area with not so well understood findings and structures. In this article, we will review the timeline of the first visualization of the most significant figures, which are expected to be present throughout the first trimester in a normally developing pregnancy. In addition, the suspicious and the diagnostic ultrasound findings of early pregnancy failure will be presented. We will highlight that the diagnosis of early pregnancy failure must be set by following the cutoff values which are established in order to eliminate the possibility of a false positive diagnosis and to avoid any harmful intervention in a viable pregnancy. Finally, we will denote the prognostic predictive value of evaluation of fetal heart rate and subchorionic hematomas presence in early pregnancy. Aim of this article is to review the literature regarding the diagnosis and prognosis of early pregnancies, improve clinicians' knowledge on this issue, and of course to help avoid or decrease possible misdiagnosis.

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Uteroplacental circulation during the first trimester of normal and abnormal pregnancy

Cited by 9 publications

References 21 publications

Comparative Study of Color Doppler Imaging in Normal and Abnormal First Trimester Pregnancy

Comparative Study of Color Doppler Imaging in Normal and Abnormal First Trimester Pregnancy

Laparoscopy Guided Doppler Ultrasound Measurement of Fetal Blood Flow Indices During Early to Mid-Gestation in Pigs

Early Pregnancy Scanning: Step-by-Step Overview

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