Uteroplacental unit as a source of elevated circulating prorenin levels in normal pregnancy

Brar, Harbinder S.; Do, Yung-Shun; Tam, Helen; Valenzuela, Guillermo J.; Murray, Rick D.; Longo, Lawrence D.; Yonekura, Masahiro; Hsueh, Willa A.

doi:10.1016/0002-9378(86)90148-1

Cited by 35 publications

(16 citation statements)

References 16 publications

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“…The form of renin predominately produced by cultured human decidual cells is also prorenin (30). The concentration of prorenin in the uterine veins of women is often higher than in their arteries when sampling is done at the time of cesarean section (31). The reason for the large increase in uterine renin during pregnancy is unknown, as is the reason for the uterine release of this large molecular weight form of renin.…”

Section: Discussionmentioning

confidence: 99%

Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving Pressure

1994

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Section: Discussionmentioning

confidence: 99%

Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving Pressure

1994

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“…The prorenin concentration in amniotic fluid is about ten times that found in the circulation of pregnant women [13]. Recent studies suggest that the utero-fetal-placental unit contributes in part to the elevated prorenin levels in the third trimester of pregnancy [29]. In addition, the ovary appears to contribute to circulating maternal prorenin levels throughout pregnancy [30].…”

Section: Utero-fetal-placental Unitmentioning

confidence: 99%

Renin in the female reproductive system

Haueh

1988

Cardiovasc Drug Ther

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The female reproductive system is characterized by the presence of local renin-angiotensin systems within the ovary and within the uterine lining. In the human ovary, renin arises from theca cells. In the uterus, the endometrium (uterine lining in the nonpregnant state) and the decidua (uterine lining in the pregnant state) are the major sources of renin. The primary form of renin produced by these extrarenal sources is prorenin. Angiotensin II, the active component of the renin cascade has a number of potential roles in the ovary and uterus. A key observation is that the human ovum and fetus is bathed in fluids rich in prorenin and angiotensin II.

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“…Early in pregnancy the ovary appears to be responsible for the increase in plasma prorenin concentration (3,4), while the uterine-fetal-placental unit may contribute in part to the prorenin rise in the third trimester (5). The exact source of uteroplacental prorenin is unknown.…”

Section: Introductionmentioning

confidence: 99%

Human decidua is a major source of renin.

Shaw¹,

S²,

Kjos³

et al. 1989

J. Clin. Invest.

110

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Plasma prorenin levels are elevated in normal pregnant women. Current evidence suggests renin production by tissues of the uteroplacental unit contribute to this elevation. The purpose of this investigation was to define the source of renin biosynthesis within the human uteroplacental unit and to characterize the renin produced. RNA extraction and Northern blot analysis consistently demonstrated renin mRNA expression in uterine lining both in the pregnant (decidua) and nonpregnant states (endometrium) and in fetal chorion laeve, which is inseparable from the decidua. In contrast, renin mRNA expression was not detected in basal plate and intertwin chorion (which is separate from decidua), amnion, myometrium, or placental villae. The total renin content in decidual homogenates was twoto threefold greater than in endometrial homogenates, and cultured human decidual cells produced significantly more total renin than cultured human endometrial cells, suggesting that pregnancy enhanced renin production by the cells lining the uterus. Immunoblot analysis and I3H]leucine incorporation identified 47,000-mol wt prorenin as the major form of renin produced by cultured human decidual cells. These studies indicate that maternal decidua is the major source of prorenin in the uteroplacental unit.

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Uteroplacental unit as a source of elevated circulating prorenin levels in normal pregnancy

Cited by 35 publications

References 16 publications

Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving Pressure

Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving Pressure

Renin in the female reproductive system

Human decidua is a major source of renin.

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