Utilidad de la ecografía en el cribado del aneurisma de aorta abdominal en atención primaria

López-Téllez, Antonio; Ramírez Torres, José Manuel; Pérez Vázquez, Estrella; Babiano Fernández, Miguel Ángel; López-Martí, Helena; Zapata Martínez, Irene; Trillo Fernández, Cristóbal; Frías Vargas, Manuel; Domínguez Pinos, María Dolores; Peiró Morant, Juan Fernando; González-Fajardo, José Antonio; Valdivielso Felices, Pedro; Aguado Castaño, Ana Carlota; Aicart Bort, María Dolores; Babiano Fernández, Miguel Ángel; Bonany Pagès, Maria Antònia; Caballer Rodilla, Julia; Cabrera Ferriols, María Ángeles; Carrasco Carrasco, Eduardo; Frías Vargas, Manuel; Fuertes Domínguez, Diana; García Lerín, Aurora; García Vallejo, Olga; Gil Gil, Inés; Lahera García, Ana; López Téllez, Antonio; Lozano Bouzon, Víctor Manuel; Padilla Sáez, Alicia; Parra Valderrama, Adriana; Peiró Morant, Juan; Perdomo García, Frank J; Pérez Vázquez, Estrella; Piera Carbonell, Ana; Pietrosanto, Teresa; Ramírez Torres, José Manuel; Ruíz Calzada, Marta; Vázquez Gómez, Natividad

doi:10.1016/j.arteri.2023.12.006

Cited by 1 publication

(1 citation statement)

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“…In addition, the transformation of vSMC to foam cells induced by oleic acid is dependent on the NLRP3 inflammasome and can be suppressed by Scutellarin 22 . Since AA shares molecular characteristics with atherosclerosis 23,24 , and atherosclerotic plaque is an important indicator of AA risk 25 , these results suggest that MUFAs may promote AA through inducing atherosclerosis.…”

Section: / 10mentioning

confidence: 89%

Heterogenous causal effects of serum fatty acid levels on the risk of cerebral and abdominal aortic aneurysm: a Mendelian Randomization study

Hang,

Yujing,

Hailan

et al. 2024

Preprint

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The presence of aneurysms, encompassing cerebral and abdominal aortic aneurysms, poses significant risks to individuals' health. The serum fatty acids (FAs) are implicated in various diseases, yet their causal association with different aneurysms remain less understood. In this study, the summary-level datasets associated with FAs and cerebral and abdominal aortic aneurysms from the UK Biobank and BioBank Japan were included. Two-sample Mendelian randomization (MR) analysis, replicated and reverse MR analysis were conducted to explore the causal association between serum FA levels with both cerebral aneurysm (CA) and abdominal aortic aneurysm (AA). The inverse variance weighting (IVW) was used as the primary method, together with sensitivity analyses for pleiotropy and heterogenous tests. As a result, the ratio of omega-6 FAs to omega-3 FAs serves as a detrimental effector of CA, and ratio of docosahexaenoic acid to total FA levels, omega-3 FA levels and ratio of omega-3 FAs to total FAs are beneficial effectors. Counterintuitively, monounsaturated FAs (MUFAs), ratio of MUFAs to total FAs, and omega-6 FAs serve as detrimental effectors of AA. Collectively, these results suggest novel serum FA levels of causal association with CA and AA, and shed light upon the distinct molecular underpinnings of the two types of aneurysms.

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