Utilidad de la tomografía por emisión de positrones con 18F-fluorodesoxiglucosa-tomografía computarizada en la identificación del tumor primario en pacientes con cáncer de origen desconocido

Talavera-Rubio, Maria del Prado; García-Vicente, Ana María; Muñoz, A. Palomar; Pilkington-Woll, John Patrick; Poblete-García, Víctor Manuel; Soriano-Castrejón, Ángel

doi:10.1016/j.medcli.2012.04.033

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Its key role has already been established in the diagnostic workup of a variety of primary tumors ( 8 ). In CUP, diagnostic 18 F-FDG PET-CT is a useful tool for the delineation of a primary focus as it provides functional and morphological information in one step with sets of CT, PET and fused images ( 9 , 10 , 11 , 12 , 13 ). Our study was conducted to evaluate the significance of FDG PET-CT in CUP syndrome in our oncologic referrals.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in the Evaluation of Carcinoma of Unknown Primary

Riaz¹,

Nawaz²,

Faruqui³

et al. 2016

Mirt

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Objective:Detection of primary tumor site in patients with carcinoma of unknown primary (CUP) syndrome has always been a diagnostic dilemma, necessitating extensive workup. Early detection of primary tumor site coupled with specific therapy improves prognosis. The low detection rate of the primary tumor site can be attributed to the biological behavior or the small size of the primary tumor to be detected by conventional imaging. The objective of this study was to evaluate the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) in detecting CUP.Methods:A retrospective, cross-sectional analysis of 100 PET-CT scans of patients with CUP syndrome between November 2009 and December 2013 was performed. Eighteen patients whose final histopathology results could not be obtained for correlation were excluded from analysis. The hypermetabolic sites were assessed in correlation with histopathology. The diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive values were assessed for PET-CT.Results:Out of the 82 patients, primary tumor was correctly identified in 57.3% patients by 18F-FDG PET-CT (true positive). The PET-CT scan results were negative for primary site localization in 15% of patients (false negative). While 21% had true negative results, 7.3% displayed false positive results. PET-CT scan upstaged the disease in 27% cases. Overall, the diagnostic accuracy was found to be 78%, sensitivity 80%, specificity 74%, positive predictive value 88.7% and negative predictive value 59%.Conclusion:Our data supports the utility of 18F-FDG PET-CT scan in the localization and staging of CUP syndrome.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in the Evaluation of Carcinoma of Unknown Primary

Riaz¹,

Nawaz²,

Faruqui³

et al. 2016

Mirt

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The Diagnostic Contribution of (18)F-FDG PET/CT Scan in Cancer of Unknown Primary

Gül

2018

Cumhuriyet Medical Journal

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The aim of the present study was to evaluate the clinically diagnostic contribution of 18 Ffluorodeoxyglucose positron emission tomography combined with computed tomography (18 F-FDG PET/CT) in patients with cancer of unknown primary (CUP). Method: The retrospective investigation, cross-sectional analysis of 124 18 F-FDG PET/CT scans of patients with CUP between June 2014 and July 2015 was performed. The increased 18 F-FDG uptake focus were assessed in correlation with histopathology. The diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive values were assessed for 18 F-FDG PET/CT. Results: The 18 F-FDG PET/CT successfully detected primary tumor in 56 patients with high 18 F-FDG uptake involvement (true positive, 45.2%). 58 patients whose final histopathology and clinically without evidence of a primary tumor (true negative, 46.8%). 8 patients whose final histopathologicallyand clinically without evidence of a primary tumor but high 18 F-FDG uptake involvement (false positive, 6.4%). The 18 F-FDG PET/CT scan results were negative for primary site localization in only 2 patients with no 18 F-FDG uptake involvement (false negative, 1.6%). Generally, the diagnostic accuracy was found to be 91.9%, sensitivity 96.5%, specificity 87.8%, positive predictive value 87.5%, negative predictive value 96.6%, positive likelihood ratio 7.9% and negative likelihood ratio 0.04%. Conclusions: It can be said that 18 F-FDG PET/CT may be useful in the diagnosis of patients with CUP.

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Utilidad de la tomografía por emisión de positrones con 18F-fluorodesoxiglucosa-tomografía computarizada en la identificación del tumor primario en pacientes con cáncer de origen desconocido

Cited by 2 publications

References 30 publications

Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in the Evaluation of Carcinoma of Unknown Primary

Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in the Evaluation of Carcinoma of Unknown Primary

The Diagnostic Contribution of (18)F-FDG PET/CT Scan in Cancer of Unknown Primary

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