Utilidad de las escalas de predicción diagnósticas de embolia de pulmón en pacientes con infección por SARS-CoV-2: una revisión sistemática

Franco-Moreno, Ana Isabel; Bustamante‐Fermosel, Ana; Ruiz‐Giardín, José Manuel; Muñoz‐Rivas, Nuria; Torres‐Macho, Juan; Brown-Lavalle, David

doi:10.1016/j.rce.2022.07.004

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…New clinical probability models for PTE that have been validated in COVID-19 patients are consequently required. 16 As previously stated, thrombotic events accompany the inflammatory process in patients with COVID-19. [8][9][10] Notably, hematological ratios are one of the valuable, inexpensive, and widely-examined markers of inflammation.…”

Section: Introductionmentioning

confidence: 86%

“…Therefore, their use as the sole diagnostic screening tool in clinical practice is not recommended. New clinical probability models for PTE that have been validated in COVID‐19 patients are consequently required 16 …”

Section: Introductionmentioning

confidence: 99%

“…New clinical probability models for PTE that have been validated in COVID‐19 patients are consequently required. 16 …”

Section: Introductionmentioning

confidence: 99%

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Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients

Radkhah,

Mansouri,

Rahimipour Anaraki

et al. 2023

Immunity Inflam & Disease

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BackgroundPulmonary thromboembolism (PTE) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which raises the COVID‐19 disease's fatality rate from 3% to 45%. Nevertheless, due to fairly indistinguishable clinical symptoms and a lack of validated clinical prediction models, PTE diagnosis in COVID‐19 patients is challenging. This study aims to investigate the applicability of hematological indices to predict PTE incidence and its severity in SARS‐CoV‐2 patients.MethodsA retrospective cohort study was conducted on hospitalized patients with a confirmed diagnosis of SARS‐CoV‐2 infection who underwent CT angiography to assess probable PTE in them. The correlation between complete blood count parameters 1 day before CT angiography and CT angiography outcomes, and simplified pulmonary embolism severity index (s‐PESI) was investigated.ResultsWe discovered that among individuals with a probable PTE, males and those with higher platelet‐to‐lymphocyte (PLR) and neutrophil‐to‐lymphocyte (NLR) ratios had a greater likelihood of PTE incidence (p < .001, .027, and .037, respectively). PLR was a significant and independent predictor of PTE with a p value of .045. Moreover, a higher neutrophil count was associated with a higher s‐PESI score in COVID‐19 patients developing PTE (p: .038).ConclusionsAmong hematological indices, NLR and more precisely PLR are cost‐effective and simply calculable markers that can assist physicians in determining whether or not COVID‐19 patients with clinically probable PTE require CT angiography and the higher neutrophil count can be employed as an indicator of PTE severity in COVID‐19 patients. Further large multicenter and prospective studies are warranted to corroborate these observations.

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