Utilidad de los esteroles vegetales en el tratamiento de la hipercolesterolemia

Fuster, Vicente

doi:10.20960/nh.1574

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Interestingly, EVOO also contains a wide range of minor components including sterols, tocopherols, triterpenic and phenolic compounds, which are involved in a profusion of pathways involved in homeostasis, inflammation and redox state [ 9 , 10 , 11 , 12 ]. Consequently, regular consumption of EVOO has been proposed as a powerful nutraceutical tool to avert and mitigate cancer and cardiovascular or degenerative diseases [ 13 , 14 ], where noticeable contributions of hydroxytyrosol and its derivates (tyrosol, oleuropein and oleocanthal) have been reported [ 15 ]. Nonetheless, some authors have claimed the need to discover additional minor bioactive components of EVOO that might help understand its beneficial properties.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

Santana-Garrido

Reyes-Goya

Milla-Navarro

et al. 2021

Foods

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Inflammation plays a crucial role in the course of eye diseases, including many vascular retinopathies. Although olive oil is known to have beneficial effects against inflammatory processes, there is no information available on the anti-inflammatory potential of the wild olive tree (namely, acebuche (ACE) for the primitive Spanish lineages). Here we investigate the anti-inflammatory effects of ACE oil in the retina of a mouse model of arterial hypertension, which was experimentally induced by administration of L-NAME (NG-nitro-L-arginine-methyl-ester). The animals were fed supplements of ACE oil or extra virgin olive oil (EVOO, for comparative purposes). Retinal function was assessed by electroretinography (ERG), and different inflammation-related parameters were measured in the retina and choroid. Besides significant prevention of retinal dysfunction shown in ERG recordings, ACE oil-enriched diet upregulated the expression of the anti-inflammatory markers PPARγ, PPARα and IL-10, while reducing that of major proinflammatory biomarkers, IL-1β, IL-6, TNF-α and COX-2. This is the first report to highlight the anti-inflammatory properties of an ACE oil-enriched diet against hypertension-related retinal damage. Noteworthy, dietary supplementation with ACE oil yielded better results compared to a reference EVOO.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

Santana-Garrido

Reyes-Goya

Milla-Navarro

et al. 2021

Foods

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Daily consumption of wild olive (acebuche) oil reduces blood pressure and ameliorates endothelial dysfunction and vascular remodelling in rats with NG-nitro-L-arginine methyl ester-induced hypertension

et al. 2022

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Purpose: Despite numerous reports on the beneficial effects of olive oil in the cardiovascular context, very little is known about the olive tree’s wild counterpart (Olea europaea, L. var. sylvestris), commonly known as acebuche (ACE) in Spain. The aim of this study was to analyse the possible beneficial effects of an extra virgin ACE oil on vascular function in a rodent model of arterial hypertension induced by L-NAME (NG-nitro-L-arginine methyl ester). Methods: Four experimental groups of male Wistar rats were studied: 1) normotensive rats (Control group); 2) normotensive rats fed a commercial diet supplemented with 15% (w/w) ACE oil (Acebuche group); 3) rats made hypertensive following administration of L-NAME (L-NAME group); and 4) rats treated with L-NAME and simultaneously supplemented with 15% ACE oil (LN+ACE group). All treatments were maintained for 12 weeks. Results: Besides a significant blood pressure-lowering effect, the ACE oil-enriched diet counteracted the alterations found in aortas from hypertensive rats in terms of morphology and responsiveness to vasoactive mediators. In addition, a decrease in hypertension-related fibrotic and oxidative stress processes was observed in L-NAME-treated rats subjected to ACE oil supplement. Conclusion: Using a model of arterial hypertension via nitric oxide depletion, here we demonstrate the beneficial effects of a wild olive oil based upon its vasodilator, antihypertensive, antioxidant, antihypertrophic and antifibrotic properties. We postulate that regular inclusion of ACE oil in the diet can alleviate the vascular remodelling and endothelial dysfunction processes typically found in arterial hypertension, thus resulting in a significant reduction of blood pressure.

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Phytochemical Content and Potential Health Applications of Pecan [Carya illinoinensis (Wangenh) K. Koch] Nutshell

Reyes-Vázquez¹,

Rosa

Morales-Landa³

et al. 2022

CTMC

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Background: The pecan nutshell contains phytochemicals with various biological activities that are potentially useful in the prevention or treatment of diseases such as cancer, diabetes, and metabolic imbalances associated with heart diseases. Objective: To update this topic by means of a literature review and include those that contribute to the knowledge of the chemical composition and biological activities of pecan nutshell, particularly of those related to the therapeutic potential against some chronic degenerative diseases associated with oxidative stress. Method: Exhaustive and detailed review of the existing literature using electronic databases. Conclusion: The pecan nutshell is a promising natural product with pharmaceutical uses in various diseases. However, additional research related to the assessment of efficient extraction methods and characterization, particularly the evaluation of the mechanisms of action in new in vivo models, is necessary to confirm these findings and development of new drugs with therapeutic use.

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Utilidad de los esteroles vegetales en el tratamiento de la hipercolesterolemia

Cited by 4 publications

References 16 publications

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

Daily consumption of wild olive (acebuche) oil reduces blood pressure and ameliorates endothelial dysfunction and vascular remodelling in rats with NG-nitro-L-arginine methyl ester-induced hypertension

Phytochemical Content and Potential Health Applications of Pecan [Carya illinoinensis (Wangenh) K. Koch] Nutshell

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