The objective of this study was to determine the effectiveness of a cardiopulmonary resuscitation (CPR) training program using medium and low fidelity simulators in primary school students for the acquisition of learning skills. Quasi-experimental pre-post study, carried out at public Elementary school in Perú. Results: nine-two students from third-to-sixth grades included, participated in this study. Assessments of knowledge, attitudes and skills were carried out immediately after the training and at 30 days. 81% passed the knowledge test immediately after training and 87% after 30 days. With the three simulators and in both measurements, the majority passed the practical skills test, with the obtained result being better in the second measurement. After the training, 96.74% felt capable of facing CPR and all at 30 days post-training. Finally, the developed training program was shown to be effective regardless of the used simulator. Conclusions: Training in CPR must begin at an early age, with age-appropriate methodologies and materials, economic possibilities and accessibility to training spaces, with periodic recycling. A CPR training program aimed at boys and girls is shown to be effective in terms of the knowledge acquisition skills, and perception of positive attitudes towards its performance using medium and low fidelity simulators.