Utilisation de la méthode du cubic simplex pour l'optimisation de la formulation a froid d'une emulsion de thioglycolate de calcium

Abstract

The aim of this work relates to the optimization of a cold formulation of a depilatory emulsion containing thioglycolate of calcium, which presents the same characteristics as a reference product. To lead to this objective, a cubic simplex method was used. A preliminary formulation was preformed to evaluate the influence of each factor on the process formulation. The depilatory creams carried out present a rheological behaviour described by the model of Hershell-Bulkely, whose parameters are considered as responses of the optimizing system. This strategy allows both reducing and optimizing the number of experiments. The rheological measurements and the tests of stability showed that the use of an emulsifying polymer led to obtain a stable depilatory cream with a good effectiveness at a strong pH value.

Determination of optimal cream formulation from long‐term stability investigation using a surface response modelling

“…In the preliminary study, the problem can be defined as maximizing the emulsion stability of determined components corresponding to optimized process conditions. In the second stage, the optimal operating conditions will be applied and the research will concern the optimal combination of an excipient mixture composition aimed to obtain a product with the required characteristics [2]. While the objective is to evaluate one or more factors that have an unquestionable effect on the formula, the experimenter in general calls upon new experimental techniques commonly called the experimental design [3].…”