Utilisation of compounds from venoms in drug discovery

Trim, Carol M.; Byrne, Lee J.; Trim, Steven A.

doi:10.1016/bs.pmch.2021.01.001

Cited by 16 publications

(8 citation statements)

References 277 publications

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“…This knowledge is fundamental for the designing of new drugs that target integrins, as it is shown that disulfide arrangements of disintegrins have an impact on integrin/disintegrin interaction. Also, it is important to point out that only a small percentage of the available disintegrins from venoms has been investigated so far and these molecules present opportunities for larger Integrin engagement surface with good stability, increasing the opportunity for the development of new drugs ( Trim et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Vasconcelos

Estrada

David

et al. 2021

Front. Mol. Biosci.

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Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell and cell-matrix interaction that are widely studied as therapeutic targets. Snake venom disintegrins emerged from the snake venom metalloproteinase and are classified according to the sequence size and number of disulfide bonds. Evolutive structure and function diversification of disintegrin family involves a stepwise decrease in the polypeptide chain, loss of cysteine residues, and selectivity. Since the structure elucidation of echistatin, the description of the structural properties of disintegrins has allowed the investigation of the mechanisms involved in integrin-cell-extracellular matrix interaction. This review provides an analysis of the structures of all family groups enabling the description of an expanded classification of the disintegrin family in seven groups. Each group presents a particular disulfide pattern and sequence signatures, facilitating the identification of new disintegrins. The classification was based on the disintegrin-like domain of the human metalloproteinase (ADAM-10). We also present the sequence and structural signatures important for disintegrin-integrin interaction, unveiling the relationship between the structure and function of these proteins.

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Section: Discussionmentioning

confidence: 99%

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Vasconcelos

Estrada

David

et al. 2021

Front. Mol. Biosci.

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“…Integrating transcriptomic and proteomic analyses should provide a better understanding of: the (i) venom composition of venomous hymenoptera in particular; and (ii) mammalian immune system responses to those stinging insects. It is hoped that this will assist in any future applications of venoms into diverse biomedicine and the possible discovery and development of new pharmacological agents and other related research areas [ 31 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae), Venom Obtention Based on an Electric Stimulation Protocol

et al. 2021

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The yellow-legged Asian hornet (Vespa velutina Lepeletier 1836 (Hymenoptera: Vespidae)) is naturally distributed in China, Southeast Asia, and India; however, recently it has been detected outside of its native area, confirmed as being established in South Korea, Europe, and Japan. Health risks and deaths caused by the invasive Vespa velutina stings have become a public health concern, being the most common cause of anaphylaxis due to hymenopterans in some European regions. This in turn has led to increased demand from medical practitioners and researchers for Vespa velutina venom for diagnostic and therapeutic purposes. In this study, a straightforward, quick, and inexpensive method for obtaining Vespa velutina venom by electric stimulation is described. The venom extracts were analyzed by nuclear magnetic resonance spectroscopy (1H-NMR). The availability of Vespa velutina venom will lead to improved diagnostic and therapeutic methods, mainly by venom immunotherapy (VIT), in patients allergic to this invasive species.

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“…Integrating transcriptomic and proteomic analyses should provide a better understanding of: the (i) venom composition of venomous hymenoptera in particular; and (ii) mammalian immune system responses to those stinging insects. It is to be hoped that this will assist any future applications of venoms into diverse biomedicine, and the possible discovery and development of new pharmacological agents, and other related research areas [31,[41][42][43][44][45].…”

Section: Resultsmentioning

confidence: 99%

Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae), Venom Obtention Based on an Electric Stimulation Protocol

Feás¹,

Vidal²,

Vázquez-Tato³

et al. 2021

Preprint

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The yellow-legged Asian hornet (Vespa velutina Lepeletier 1836 (Hymenoptera: Vespidae)) is naturally distributed in China, Southeast Asia and India; however it has since detected outside of its native area, confirmed as being established in South Korea, Europe and Japan. Health risks and deaths caused by the invasive Vespa velutina stings have become a public health concern, being the most common cause of anaphylaxis due to hymenopterans in some European regions. This in turn has led to increased demand from medical practitioners and researchers for Vespa velutina venom for diagnostic and therapeutic purposes. In this study, a straightforward, quick and inexpensive method for obtaining Vespa velutina venom by electric stimulation is described. The venom extracts were analyzed by nuclear magnetic resonance spectroscopy (1H-NMR), confirming the composition of the obtained material. The availability of Vespa velutina venom will lead to improved diagnostic and therapeutic methods, mainly by venom immunotherapy (VIT), in patients allergic to this invasive species.

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Utilisation of compounds from venoms in drug discovery

Cited by 16 publications

References 277 publications

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae), Venom Obtention Based on an Electric Stimulation Protocol

Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae), Venom Obtention Based on an Electric Stimulation Protocol

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