Modern medicine, which is sometimes inaccessible because of its high cost or sometimes ineffective in treating serious or chronic illnesses, is replaced by traditional medicine, often practiced by herbalists or traditional practitioners. 4 Unfortunately, these practitioners often lack adequate training to diagnose illnesses and correctly use phytotherapy. 5 The use of medicinal and aromatic plants (MAP) for phyto-therapeutic purposes by the local population is often associated with risks, mainly owing to the inappropriate use of these plants. 6 This may result from incorrect dosage, inadequate choice of the active plant part, or simply the use of highly toxic plants due to a lack of knowledge, or, worse still, consuming them at the same time as medicines without any idea of plant-drug interactions. 7 These practices can lead to therapeutic failure or toxic accidents, which can be fatal. It is important to note that toxicity caused by MAP accounts for approximately 5.1% of all intoxications, excluding scorpionic stings and envenomations. 8,9 The objectives of this pharmacy-based study were to target patients affected by various pathologies, such as gastrointestinal, cardiovascular, urinary, gynecological, and endocrine diseases, as well as cancer cases, in the provinces of Meknes, Lhajeb, Boufkrane, Azrou, Lkbab, Aguelmouss, Ifrane, and Khenifra. This study aimed to document and analyze the medicinal and aromatic plant use practices in the Moroccan Middle Atlas region. In addition, this study aimed to identify the most frequently used plants, analyze preparation methods, explore the most commonly used plant parts, assess their possible adverse effects and their associations with drugs, and evaluate the factors influencing the choice of MAP use.