This study investigates the critical role of information systems and digital transformation in advancing sustainable supply chain management. Companies are increasingly adopting sustainable policies to protect the environment, enhance societal wellbeing, and drive economic development. By digitalizing their processes, they achieve significant operational improvements and boost business performance. Information systems are now integral to supply chains, supporting diverse processes and facilitating excellence in digital transformation and sustainable development. However, research in this area has been limited, focusing primarily on the environmental pillar. This study aims to explore the relationship between supply chain digitalization and the adoption of comprehensive sustainability practices. The research employs a qualitative methodology, including a comparative case study analysis of a modern 3PL company, a retailer, and a producer of construction materials. The findings reveal that the strategic integration of digital transformation and sustainable policies within organizational contexts is vital for enhancing business performance and achieving operational excellence. Effective use of information systems and resources enables companies to amplify their economic, social, and environmental impact, fostering an environmentally friendly image, strengthening societal relationships, and increasing market share. This study underscores the importance of a holistic approach to sustainability, driven by information systems and Industry 4.0 technologies, positioning companies as leaders in sustainable supply chain management.