Utilities for asthma and COPD according to category of severity: a comprehensive literature review

Einarson, Thomas R.; Bereza, Basil G; Nielsen, T Anders; Hemels, M.

doi:10.3111/13696998.2015.1025793

Cited by 29 publications

(16 citation statements)

References 103 publications

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“…A meta-analysis study acknowledged a considerable amount of variation across studies. However, there was consensus on the finding that the greater the severity, the greater the degree of deterioration of quality of life [10,11,47].…”

Section: Discussionmentioning

confidence: 99%

“…Pickard et al [10] and Einarson et al [11] reported that the utility measure reflects the clinical severity of COPD well, as evidenced by lower utility scores when disease severity is higher. However, many other studies have reported that the discriminatory ability of a multi-attribute utility (MAU) measure, such as the five-dimensional EuroQol (EQ-5D) utility index, is limited with respect to measuring the quality of life of patients with COPD [4,[10][11][12][13][14]. Therefore, there is an increasing tendency to use condition-specific measures (CSMs), which are more sensitive to the detection of small treatment effects.…”

Section: Introductionmentioning

confidence: 99%

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Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease

et al. 2020

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Background: The discriminatory ability of multi-attribute utility (MAU) measures compared to condition-specific measures (CSM) in assessing health-related quality of life (HRQoL) among patients with chronic obstructive pulmonary disease (COPD) is an unsettled issue. This study investigated the quality of life of patients with COPD with three different HRQoL instruments and examined whether they could differentiate between adjacent severity groups in a statistically and clinically meaningful manner. In the process, the minimal clinically important differences (MCID) of the EQ-5D utility index were estimated. Methods: Cross-sectional survey data were collected from patients with mild to very severe COPD in South Korea. In addition to demographic and clinical information, the following HRQoL questionnaires were used: The three-level five-dimensional Euro-Quality of Life tool (EQ-5D-3L), the EQ-Visual Analog Scale (EQ-VAS), and the Chronic Obstructive Pulmonary Disease Assessment Test (CAT). Patients' health-related quality of life was analyzed with reference to severity groups based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. To investigate the discriminatory ability of the HRQoL instruments between COPD severity groups, tests examining variance, covariance, and standardized mean difference were performed. After estimating the MCID of the EQ-5D utility index using the anchor-based method, we investigated whether the differences in the EQ-5D utility scores between groups exceeded the clinically meaningful minimum level. Results: A total of 298 patients completed this study. All the quality of life scores showed statistically significant differences between the GOLD severity groups. The pooled MCID estimate for the EQ-5D utility index was 0.028 (range: 0.017-0.033). Even after adjusting for other factors affecting quality of life, the EQ-5D utility index differentiated the GOLD groups well. Conclusions: We conclude that the EQ-5D utility index is a valid instrument for measuring the quality of life of patients with COPD, and the pooled MCID estimate for the EQ-5D utility index was 0.028.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease

et al. 2020

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“…Einarson et al reviewed 44 original articles that reported utilities related to COPD [ 41 ]. Irrespective of disease classification and utility instrument, methods or tariffs used, mean utilities were 0.83, 0.77, 0.71, and 0.61 for GOLD grades 1–4 respectively.…”

Section: Discussionmentioning

confidence: 99%

Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies

Wacker¹,

Jörres

Karch

et al. 2016

Respir Res

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BackgroundHealth-related quality of life (HRQL) is an important patient-reported outcome measure used to describe the burden of chronic obstructive pulmonary disease (COPD) which is often accompanied by comorbid conditions.MethodsData from 2275 participants in the COPD cohort COSYCONET and from 4505 lung-healthy control subjects from the population-based KORA and SHIP studies were pooled. Main outcomes were the five dimensions of the generic EQ-5D-3 L questionnaire and two EQ-5D index scores using a tariff based on valuations from the general population and an experience-based tariff.The association of COPD in GOLD grades 1–4 and of several comorbid conditions with the EQ-5D index scores was quantified by multiple linear regression models while adjusting for age, sex, education, body mass index (BMI), and smoking status.ResultsFor all dimensions of the EQ-5D, the proportion of participants reporting problems was higher in the COPD group than in control subjects. COPD was associated with significant reductions in the EQ-5D index scores (-0.05 points for COPD grades 1/2, -0.09 for COPD grade 3, -0.18 for COPD grade 4 according to the preference-based utility tariff, all p < 0.0001). Adjusted mean index scores were 0.89 in control subjects and 0.85, 0.84, 0.81, and 0.72 in COPD grades 1-4 according to the preference-based utility tariff and 0.76, 0.71, 0.68, 0.64, and 0.58 for control subjects and COPD grades 1-4 for the experience-based tariff respectively. Comorbidities had additive negative effects on the index scores; the effect sizes for comorbidities were comparable to or smaller than the effects of COPD grade 3. No statistically significant interactions between COPD and comorbidities were observed. Score differences between COPD patients and control subjects were most pronounced in younger age groups.ConclusionsCompared with control subjects, the considerable reduction of HRQL in patients with COPD was mainly due to respiratory limitations, but observed comorbidities added linearly to this effect. Younger COPD patients showed a greater loss of HRQL and may therefore be in specific need of comprehensive disease management.Trial registrationNCT01245933

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“…Es posible que la pérdida de peso en pacientes con EPOC gradados en GOLD C y D sea en sí mismo un indicador de deterioro funcional y no la causa de éste, es decir, no es la falta de peso por pérdida de masa muscular o grasa corporal responsable del deterioro de la función pulmonar, el funcionamiento global y la mortalidad del paciente con EPOC (6,19,28) . De igual manera, considerar la naturaleza arbitraria de la clasificación GOLD que ha mostrado problemas por no seguir una secuencia lineal de menor a mayor frecuencia de exacerbaciones, A<B<C<D y las variaciones importantes que se dan en la clasificación según la escala usada para cuantificar los síntomas (29,30) .…”

Section: Discussionunclassified

Relación entre el índice de masa corporal y la frecuencia de exacerbaciones en pacientes con enfermedad pulmonar obstructiva crónica en Santa Marta, Colombia

2019

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Introducción: El índice de masa corporal (IMC) se asocia inversamente a la frecuencia de exacerbaciones en pacientes con enfermedad pulmonar obstructiva crónica (EPOC); sin embargo, esta puede variar según el contexto. Objetivo: Cuantificar la asociación entre el IMC y la frecuencia de exacerbaciones en pacientes en Santa Marta, Colombia. Materiales y métodos: Estudio transversal de adultos con EPOC. Se calculó el IMC y la frecuencia de exacerbaciones se estimó a partir de la clasificación GOLD de estado global. Resultados: Participaron 292 pacientes entre 49 y 95 años; 61,6% eran hombres. Los IMC se observaron entre 12,8 y 40,2 (media=24,2; DE=4,5) distribuidos en 21 pacientes (7,2%) con desnutrición; 153 (52,4%), saludables; y 118 (40,4%), sobrepeso-obesidad. Un total de 146 pacientes (53,4%) se clasificaron GOLD A o B (exacerbaciones no frecuentes); y 136 pacientes (46,6%), GOLD C o D (exacerbaciones frecuentes). El 85,7% de los pacientes con desnutrición presentaron exacerbaciones frecuentes comparado con 51,6% en pacientes con peso saludable y 33,1% en pacientes con sobrepeso-obesidad (OR=0,18; IC95% 0,05-0,66 para peso saludable y OR=0,08; IC95% 0,02-0,29 para sobrepeso-obesidad frente a desnutrición). Conclusiones: El IMC presenta una relación inversa con la frecuencia de exacerbaciones en pacientes con EPOC de Santa Marta, Colombia.

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Utilities for asthma and COPD according to category of severity: a comprehensive literature review

Abstract: Utilities have been summarized according to severity category of asthma and COPD. These values should be useful for researchers undertaking economic analyses of these diseases.

Cited by 29 publications

References 103 publications

Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease

Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease

Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies

Relación entre el índice de masa corporal y la frecuencia de exacerbaciones en pacientes con enfermedad pulmonar obstructiva crónica en Santa Marta, Colombia

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