Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

Krahn, Murray; Bremner, Karen E.; Tomlinson, George; Naglie, Gary

doi:10.1038/pcan.2009.32

Cited by 34 publications

(51 citation statements)

References 27 publications

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“…First, not all studies used the self-administered questionnaires ICIQ and IIEF to assess UI and ED in patients with prostate cancer which represent simple and applicable self-assessment instruments to all patients. Other instruments used were the Expanded Prostate Cancer Index Composite (EPIC) questionnaire [17,28], Health-related Quality of Life (HRQOL) questionnaires [29,30] or direct interview of patients by telephone or face-to-face [31]. Second, the definition of UI and ED is not standardised [18] throughout the studies and these differences are clinically relevant.…”

Section: Discussionmentioning

confidence: 99%

Patient-Reported Urinary Incontinence and Erectile Dysfunction Following Radical Prostatectomy: Results from the European Prostate Centre Innsbruck

et al. 2015

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Introduction: Urinary and erectile functions were assessed by using self-administered validated questionnaires in patients undergoing radical prostatectomy. Materials and Methods: In a prospective observational study, a total of 253 consecutive patients diagnosed with clinically localised prostate cancer between 2008 and 2009 at the European Prostate Centre Innsbruck were included. Patient-reported outcomes were assessed before radical prostatectomy and 12 months postoperatively using the validated International Consultation on Incontinence Questionnaire (ICIQ) and the International Index of Erectile Function (IIEF). The Wilcoxon signed-rank test and Chi square statistics were used for analysis. Results: The study showed that before radical prostatectomy, urinary incontinence of various severity grades was reported in 18.8, postoperatively in 63.0% (p < 0.001) and erectile dysfunction of various degrees was reported in 39.6 at baseline compared to 80.1% 12 months postoperatively (p < 0.001). Conclusions: This study suggests that radical prostatectomy is associated with a significantly increased risk of urinary incontinence and erectile dysfunction 12 months postoperatively.

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Section: Discussionmentioning

confidence: 99%

Patient-Reported Urinary Incontinence and Erectile Dysfunction Following Radical Prostatectomy: Results from the European Prostate Centre Innsbruck

et al. 2015

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“…Furthermore, men not receiving ADT had poorer urinary function compared with men on ADT. Because RPRT directly affect the urinary system, 22,23 it is expected that those who received these procedures more frequently (non-ADT users) would have poorer urinary function than those who received ADT alone. Second, underserved men with prostate cancer are often diagnosed at a later stage and receive ADT as primary treatment.…”

Section: Discussionmentioning

confidence: 99%

Long-term quality of life in disadvantaged men with prostate cancer on androgen-deprivation therapy

Sevilla

Maliski

Kwan

et al. 2012

Prostate Cancer Prostatic Dis

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BACKGROUND:To explore the effects of androgen-deprivation therapy (ADT) on general, disease-specific and hormone-specific health-related quality of life (HRQOL) among minority men. METHODS: Men enrolled in a state-funded program, providing free prostate cancer treatment for underserved men, were recruited, if they had received at least 3 months of continuous ADT and/or other forms of primary treatment. HRQOL was assessed with validated measures including the RAND Medical Outcomes Study 12-item Health Short Form Survey (SF-12), the UCLA Prostate Cancer Index Survey and the Expanded Prostate Cancer Index Composite Survey. Repeated measures analysis was performed to evaluate the association between clinical and sociodemographic covariates with HRQOL. RESULTS: We enrolled 322 men, including 94 on ADT and 228 who received other forms of treatment. When controlling for patient characteristics, men receiving ADT had poorer outcomes relative to sexual function (Po0.01), sexual bother (Po0.01), hormonal function (Po0.01) and hormonal bother (P ¼ 0.02). ADT use was significantly associated with worsening sexual function (Po0.01) and sexual bother (P ¼ 0.01) over two years compared with non-ADT users. Analysis also demonstrated significant differences between whites, Hispanics and Others (African American (n ¼ 43, 16%), Asian (n ¼ 13, 5%), multiracial (n ¼ 1, 0.4%), Native American (n ¼ 1, 0.4%) and other (n ¼ 9, 3%)) relative to urinary bother (P ¼ 0.01), urinary function (P ¼ 0.01) and hormonal bother (P ¼ 0.03). ADT users had better urinary function and less bother than non-ADT users among the Other group, while the opposite was true for whites and Hispanics. For hormonal bother, ADT use was associated with worse outcomes across all three race/ethnicity groups; however, Hispanics were less bothered by their hormonal symptoms than whites or Others. CONCLUSION: Men of disadvantaged backgrounds on hormone therapy for prostate cancer experience declines in sexual and hormonal HRQOL. Whites and non-whites on ADT have significantly different HRQOL outcomes.

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“…The PORPUS is a 10-item questionnaire that asks patients to describe their HRQOL status by selecting 1 of 5 possible conditions in the following domains: pain and disturbing body sensations, energy, support from family and friends, communication with doctor, emotional well-being, urinary frequency, bladder control, sexual function, sexual drive, and bowel problems. The PORPUS has been used in several studies to assess treatment-related changes in HRQOL [45][46][47][48][49].…”

Section: Psychosocial Outcomesmentioning

confidence: 99%

Group Exercise versus Personal Training for Prostate Cancer Patients: A Pilot Randomized Trial

Mina¹,

Ritvo²,

Matthew³

et al. 2012

JCT

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Background: Previous studies have demonstrated psychosocial and physical benefit from exercise for older men treated with androgen deprivation therapy (ADT) for prostate cancer (PCa). To date, different intervention delivery methods have not been assessed. This study compared the effect of group-based exercise (GBE) to personal training (PT) in men undergoing ADT for PCa. Methods: 13 participants (mean age = 68.2, SD = 7.2) were randomly assigned to GBE or PT for 8 weeks. Participants exercised for 60 minutes three times per week at a moderate-vigorous intensity. Results: 10 participants completed the intervention. At post-intervention, the PT group improved: fatigue, systolic BP, waist circumference, body fat percentage, and maximal leg strength; participants in the GBE group improved leg strength. At 8 weeks, maximal upper body strength in the PT group was greater than the GBE group. There were no adverse events associated with moderate-high intensity training in this population of older men. Conclusion: PT may be more efficacious than GBE in improving several physical fitness outcomes and fatigue in men with PCa who are androgen deprived. Due to the small sample size and attrition, these results require cautious interpretation and confirmation from adequately powered trials.

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Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

Cited by 34 publications

References 27 publications

Patient-Reported Urinary Incontinence and Erectile Dysfunction Following Radical Prostatectomy: Results from the European Prostate Centre Innsbruck

Patient-Reported Urinary Incontinence and Erectile Dysfunction Following Radical Prostatectomy: Results from the European Prostate Centre Innsbruck

Long-term quality of life in disadvantaged men with prostate cancer on androgen-deprivation therapy

Group Exercise versus Personal Training for Prostate Cancer Patients: A Pilot Randomized Trial

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