Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction

Maisel, Alan S.; Koon, Jen; Krishnaswamy, Padma; Kazenegra, Radmila; Clopton, Paul; Gardetto, Nancy; Morrisey, Robin; Garcia, Alex V. Mejia; Chiu, Albert; Maria, Anthony De

doi:10.1067/mhj.2001.113215

Cited by 341 publications

(246 citation statements)

References 45 publications

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“…In contrast to the experience from adult acquired and paediatric heart disease [11][12][13], and therefore somewhat surprising, the association between ejection fraction and peptide concentrations was weak in this study. Although subjects with moderately or severely impaired ventricular function did have elevated NP concentrations as compared with subjects with normal or only mildly impaired ventricular function, the association was weak and the difference only statistically significant when BNP and NT-proBNP data were combined.…”

Section: Discussioncontrasting

confidence: 51%

The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation

Larsson

Meurling

Holmqvist

et al. 2007

International Journal of Cardiology

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Section: Discussioncontrasting

confidence: 51%

The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation

Larsson

Meurling

Holmqvist

et al. 2007

International Journal of Cardiology

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“…Similarly, other studies have also used more sensitive values for the diagnosis of HF-PLEF. For example, in a study of patients with normal systolic function on echocardiogram, plasma BNP ≥ 57 pg/mL detected the 28 patients with isolated abnormal diastolic function with 100% positive predictive value [23]. Another study which evaluated 294 patients with normal left ventricular function, reported that plasma BNP ≥ 62 pg/mL had a sensitivity of 85% and a specificity of 83% for the diagnosis of diastolic dysfunction [24].…”

Section: Discussionmentioning

confidence: 99%

BNP and NT‐proBNP predict echocardiographic severity of diastolic dysfunction

Grewal

McKelvie

Lonn

et al. 2008

European J of Heart Fail

108

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Aims: To evaluate the best combination of clinical parameters and brain natriuretic peptide (BNP) or N-terminal pro-BNP (NT-proBNP), to predict diastolic dysfunction (DD) in heart failure with preserved left ventricular ejection fraction (HF-PLEF) as determined by Dopplerechocardiography. Methods and Results: HF patients with EF N 40% in the CHARM Echocardiographic Substudy were included and classified to have normal diastolic function, or mild, moderate or severe diastolic dysfunction. Plasma BNP and NT-proBNP levels were measured and relevant clinical characteristics recorded. 181 participants were included in this analysis, 72 (40%) had moderate to severe DD. A model including age, sex, BNP, body mass index, history of atrial fibrillation, coronary artery disease, diabetes mellitus, hypertension and left atrial volume was highly predictive of moderate to severe DD; AUC 0.81 (0.73-0.88; p b 0.0001). Similarly, substitution of BNP with NT-proBNP resulted in an AUC 0.79 (0.72-0.87; p b 0.0001). In these models; BNP N 100 pg/ml (OR 6.24 CI 2.42-16.09, p = 0.0002), history of diabetes (OR 3.52 CI 1. 43-8.70, p = 0.006) and NT-proBNP N 600 pg/ml , p = 0.0004), history of diabetes mellitus (OR 2.75 CI 1.12-6.76, p = 0.03) respectively remained independent predictors of DD in HF-PLEF. Conclusions: Natriuretic peptides were the strongest independent predictors of DD, as determined by Doppler-echocardiography, in HF-PLEF.

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“…During the past 10 years, several studies have confirmed the usefulness of B-type natriuretic peptide (BNP), a neurohormone elevated in response to volume overload, in the diagnosis and treatment of CHF. 99 Recent studies in patients with cancer have shown that high levels of BNP correlated with impairment of LV function during anthracycline therapy. 100,101 BNP has also been shown to be elevated before the development of LV dysfunction in patients undergoing high-dose therapy and hematopoietic stem cell transplantation.…”

Section: Monitoring Cardiovascular Toxicitymentioning

confidence: 99%

Cardiovascular Complications of Cancer Therapy

et al. 2004

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Abstract-The cardiotoxicity of anticancer agents can lead to significant complications that can affect patients being treated for various malignancies. The severity of such toxicity depends on many factors such as the molecular site of action, the immediate and cumulative dose, the method of administration, the presence of any underlying cardiac condition, and the demographics of the patient. Moreover, toxicity can be affected by current or previous treatment with other antineoplastic agents. Cardiotoxic effects can occur immediately during administration of the drug, or they may not manifest themselves until months or years after the patient has been treated. In this article we review commonly used chemotherapy agents, including several recently approved medications, for their propensity to cause cardiotoxicity. Further research will be required to more accurately predict which patients are at risk for developing cardiotoxicity. In addition, management plans, as well as strategies to reduce cardiotoxicity, need to be developed.

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Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction

Cited by 341 publications

References 45 publications

The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation

The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation

BNP and NT‐proBNP predict echocardiographic severity of diastolic dysfunction

Cardiovascular Complications of Cancer Therapy

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