Utility of bilateral inferior petrosal sinus sampling for diagnosis and lateralization of Cushing’s disease in the pediatric population: case series and review of the literature

Kang, Keiko M.; Muralidharan, Koushik; Knowlton, Harrison; Hassan, Khalid; Yekula, Anudeep; Misra, Madhusmita; Swearingen, Brooke; Jones, Pamela S.

doi:10.1007/s40618-021-01680-8

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…This is in accordance with some authors who state that the capacity of BIPSS to localize intra-pituitary tumors is limited, regardless of the stimulus used ( 1 ). Recent studies of BIPSS with CRH stimulation performed in children showed a lateralizing accuracy of 58.3% (7/12) ( 5 ) and 69% (9/13) ( 11 ). However, it was not specified whether the accuracy was calculated before or after stimulation.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Power of Bilateral Inferior Petrosal Sinus Sampling with Desmopressin in Paediatric Cushing’s Disease

Virú-Loza¹,

Quispe²

2022

Jcrpe

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Objective: The aim of this study was to evaluate the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS) with desmopressin for pediatric Cushing’s disease (CD). Methods: We reviewed studies performed in children that evaluated the accuracy of BIPSS with desmopressin. Results: All included studies were case series of children with adrenocorticotropin hormone (ACTH)-dependent Cushing’s syndrome. The overall accuracy of BIPSS before stimulation was 84.1% (37/44), and after stimulation it was 92.3% (36/39). The overall lateralizing accuracy of BIPSS was 50.0%. Conclusion: Considering that available evidence is limited, it appears that BIPSS with desmopressin stimulation is accurate for the diagnosis of pediatric CD, but its lateralizing accuracy is probably not suitable for pediatric clinical practice.

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Section: Discussionmentioning

confidence: 99%