Utility of Biochemical Markers of Bone Turnover and Bone Mineral Density in Management of Osteoporosis

Vasikaran, Samuel

doi:10.1080/10408360801949442

Cited by 79 publications

(45 citation statements)

References 166 publications

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“…Generally, this bone marker is reduced when bone stability is increased (Briot and Roux, 2005;Vasikaran, 2008) and in this study, Phy clearly increased BMD, BMC, and breaking strength. Probably, the elevated concentration of SCL was not a sign of decreased bone stability but of accelerated bone turnover.…”

Section: Discussionmentioning

confidence: 92%

Influence of benzoic acid and phytase in low-phosphorus diets on bone characteristics in growing-finishing pigs1

Bühler

Liesegang

Bucher

et al. 2010

Journal of Animal Science

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ABSTRACT:In 2 simultaneous experiments (Exp. 1 and Exp. 2), the effects of benzoic acid (BA) and phytase (Phy) in low-P diets on bone metabolism, bone composition, and bone stability in growing and growing-finishing pigs were examined. Exp. 1 was conducted with 16 crossbred gilts in the weight range of 25 to 66 kg BW, whereas in Exp. 2, 32 crossbred gilts (25 to 108 kg BW) were used. All pigs were individually housed in pens and restrictively fed one of 4 diets throughout the experiment. Total P content of the wheat-soybean diets was 4 g/kg (all values asfed basis). The experimental diets were: 1) CC, unsupplemented control diet; 2) CBA, control diet with 0.5% BA; 3) PhyC, Phy diet with 750 Phy unit (FTU) Phy/kg and no BA; and 4) PhyBA, control diet with 750 FTU Phy/kg and 0.5% BA . Blood samples were taken at the beginning of the experiment, wk 3 (only for pigs in Exp. 1), wk 6, and before slaughter to determine P and Ca in serum and concentrations of total alkaline phosphatase (AP), serum crosslaps (SCL, marker for bone resorption), and osteocalcin (OC, marker for bone formation).Ash, P, and Ca contents of bones and bone stability were examined using the left metatarsal bones and tibia of the pigs after slaughter. Benzoic acid did not influence any of the blood variables (P > 0.09). The addition of Phy increased (P ≤ 0.03) P concentration in serum from 2.71 ± 0.08 to 3.03 ± 0.07 mmol/L at wk 3 and SCL content from 0.39 ± 0.02 to 0.45 ± 0.02 ng/mL at wk 6 and decreased (P < 0.05) OC at wk 6 by 160 ng/mL. No long-term effect of diets on serum mineral concentrations, AP, and bone markers in serum could be detected. Benzoic acid negatively affected (P ≤ 0.03) Ca content in bones and distal bone mineral density, especially in the younger pigs. In diets CBA and PhyBA, these variables were reduced by 6 and 11%, respectively. Throughout the whole growing and finishing period, Phy increased (P ≤ 0.02) ash, P, and Ca contents in bones by 29.4, 4.8, and 11.6 g/kg DM. Bone mineral density and bone mineral content were higher in diets with Phy (P ≤ 0.03), as well as breaking strength of tibia (+ 3 22%) and metatarsal bones (+ 27%; P < 0.01). The results of this study indicate that for a healthy skeleton, BA should not be used in low-P diets without the addition of Phy.

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Section: Discussionmentioning

confidence: 92%

Influence of benzoic acid and phytase in low-phosphorus diets on bone characteristics in growing-finishing pigs1

Bühler

Liesegang

Bucher

et al. 2010

Journal of Animal Science

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“…TRAcP is localized within the ruffled border area of the osteoclasts, where it plays a role in bone resorption via the production of destructive hydroxyl radicals [60,61] . CTX telopeptides are proteolytic fragments of type 1 collagen formed during bone resorption [62] . CTX telopeptides are sensitive and specific markers of bone resorption in the context of metabolic bone disease [63] .…”

Section: Effects On Bone Histopathologymentioning

confidence: 99%

The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model

et al. 2014

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Aim: depression is a risk factor for impaired bone mass and micro-architecture, but several antidepressants were found to increase the incidence of osteoporotic fractures. in the present study we used ovariectomized (oVX) rats as a model of osteoporosis to investigate the effects of the antidepressant bupropion on the femoral bones. Methods: oVX animals were treated with bupropion (30, 60 mg·kg -1 ·d -1 ) for six weeks. bone turnover biomarkers (urinary dPd/Cr ratio, serum BALP, OC, TRAcP 5b, CTX and sRANKL levels) and inflammatory cytokines (TNF-α, IL-1β and IL-6) were determined using ELISA. inductively coupled plasma mass spectroscopy (iCP-Ms) was used to determine the femoral bone mineral concentrations. The cortical and trabecular morphometric parameters of femoral bones were determined using micro-CT scan and histopathology. Results: In OVX rats, the levels of bone turnover biomarkers and inflammatory cytokines were significantly elevated and femoral bone Ca 2+ and Po 4 3-concentrations were significantly reduced. Moreover, cortical and trabecular morphometric parameters and histopathology of femoral bones were severely altered by ovariectomy. bupropion dose-dependently inhibited the increases in bone turnover biomarkers and inflammatory cytokines. OVX rats treated with the high dose of bupropion showed normal mineral concentrations in femoral bones. The altered morphometric parameters and histopathology of femoral bones were markedly attenuated by the treatment. Conclusion: bupropion exerts osteo-protective action in oVX rats through suppressing osteoclastogenesis-inducing factors and inflammation, which stabilize the osteoclasts and decrease bone matrix degradation or resorption.

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“…The LSC was less for the raloxifene study -45% CTX and -27% PINP in comparison to the TRIO study (-56% CTX, -38% PINP). There are several ways that LSC can be calculated [10,29] .…”

Section: Discussionmentioning

confidence: 99%

Response of bone turnover markers to raloxifene treatment in postmenopausal women with osteopenia

et al. 2016

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Introduction: The change in bone turnover markers (BTM) in response to osteoporosis therapy can be assessed by a decrease beyond the least significant change (LSC) or below the mean of the reference interval (RI). We compared the performance of these two approaches in women treated with raloxifene.Methods: Fifty postmenopausal osteopenic women, (age 51-72y) were randomised to raloxifene or no treatment for 2 years. Blood samples were collected for the measurement of BTM. The LSC for each marker was calculated from the untreated women and the RI obtained from healthy premenopausal women (age 35-40y). Bone mineral density (BMD) was measured at the spine and hip.Results: There was a decrease in BTM in response to raloxifene treatment; percentage change at 12 weeks, CTX -39% (95% CI -48 to -28) and PINP -32% (95% CI -40 to -23) P<0.001. The proportion of women classified as responding to treatment using LSC at 12 weeks was: CTX 38%, PINP 52%, at 48 weeks CTX 60%, PINP 65%. For the RI approach; at 12 weeks CTX and PINP 38%, at 48 weeks CTX 40%, PINP 45%. There was a significant difference in the change in spine BMD in the raloxifene treated group compared to the no-treatment group at week 48; difference 0.031 g/cm2, (95% CI 0.016 to 0.046, P<0.001).Conclusions: The two approaches identified women that reached the target for treatment using BTM.Both LSC and RI criteria appear useful in identifying treatment response but the two approaches do not fully overlap and may be complementary.

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Utility of Biochemical Markers of Bone Turnover and Bone Mineral Density in Management of Osteoporosis

Cited by 79 publications

References 166 publications

Influence of benzoic acid and phytase in low-phosphorus diets on bone characteristics in growing-finishing pigs1

Influence of benzoic acid and phytase in low-phosphorus diets on bone characteristics in growing-finishing pigs1

The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model

Response of bone turnover markers to raloxifene treatment in postmenopausal women with osteopenia

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