Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-Cancer Activity

El-Hameed, Rania Helmy Abd; El-Shanbaky, Hend Medhat; Mohamed, Mosaad S.

doi:10.2174/1573406417666210604103135

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…The study recommended the downregulation of both MAPK14 and P-MAPK14 by downregulating CDC25B as a possible method to suppress the proliferation and migration of ccRCC [ 40 ]. By downregulating MAPK14 in renal cancer cells lines using a 2-Furanone compound called “compound 3a”, Abd El-Hameed et al [ 41 ] showed that these have promising anticancer activities and corroborrate our suggestion that MAPK14 could be a very promising target against kidney cancer.…”

Section: Discussionsupporting

confidence: 71%

Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Kidney Cancers

Ioannou

Chatziantoniou

Drenios

et al. 2023

IJMS

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There are several studies on the deregulated gene expression profiles in kidney cancer, with varying results depending on the tumor histology and other parameters. None of these, however, have identified the networks that the co-deregulated genes (co-DEGs), across different studies, create. Here, we reanalyzed 10 Gene Expression Omnibus (GEO) studies to detect and annotate co-deregulated signatures across different subtypes of kidney cancer or in single-gene perturbation experiments in kidney cancer cells and/or tissue. Using a systems biology approach, we aimed to decipher the networks they form along with their upstream regulators. Differential expression and upstream regulators, including transcription factors [MYC proto-oncogene (MYC), CCAAT enhancer binding protein delta (CEBPD), RELA proto-oncogene, NF-kB subunit (RELA), zinc finger MIZ-type containing 1 (ZMIZ1), negative elongation factor complex member E (NELFE) and Kruppel-like factor 4 (KLF4)] and protein kinases [Casein kinase 2 alpha 1 (CSNK2A1), mitogen-activated protein kinases 1 (MAPK1) and 14 (MAPK14), Sirtuin 1 (SIRT1), Cyclin dependent kinases 1 (CDK1) and 4 (CDK4), Homeodomain interacting protein kinase 2 (HIPK2) and Extracellular signal-regulated kinases 1 and 2 (ERK1/2)], were computed using the Characteristic Direction, as well as GEO2Enrichr and X2K, respectively, and further subjected to GO and KEGG pathways enrichment analyses. Furthermore, using CMap, DrugMatrix and the LINCS L1000 chemical perturbation databases, we highlight putative repurposing drugs, including Etoposide, Haloperidol, BW-B70C, Triamterene, Chlorphenesin, BRD-K79459005 and β-Estradiol 3-benzoate, among others, that may reverse the expression of the identified co-DEGs in kidney cancers. Of these, the cytotoxic effects of Etoposide, Catecholamine, Cyclosporin A, BW-B70C and Lasalocid sodium were validated in vitro. Overall, we identified critical co-DEGs across different subtypes in kidney cancer, and our results provide an innovative framework for their potential use in the future.

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Section: Discussionsupporting

confidence: 71%

Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Kidney Cancers

Ioannou

Chatziantoniou

Drenios

et al. 2023

IJMS

View full text Add to dashboard Cite

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Iron‐Mediated C−H Functionalization of Unactivated Alkynes for the Synthesis of Derivatized Dihydropyrrolones: Regioselectivity Under Thermodynamic Control

Durham

Liu

Wang

2023

Chemistry A European J

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Cyclopentadienyliron dicarbonyl‐based complexes present opportunities for underexplored disconnections in synthesis. Access to challenging dihydropyrrolone products is achieved by propargylic C−H functionalization of alkynes for the formation of cyclic organoiron species. Excellent regioselectivity for unsymmetrical alkynes is observed in many cases. Notably, regioselectivity under these stoichiometric conditions diverges from those observed previously under catalysis, occurring at the more‐substituted terminus of the alkyne, allowing for methine functionalization and the formation of quaternary centers. Divergent demetallation of the intermediate organoiron complexes gives access to chemically diverse products which are amenable to further functionalization.

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Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-Cancer Activity

Cited by 2 publications

References 36 publications

Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Kidney Cancers

Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Kidney Cancers

Iron‐Mediated C−H Functionalization of Unactivated Alkynes for the Synthesis of Derivatized Dihydropyrrolones: Regioselectivity Under Thermodynamic Control

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