Utility of Certain π‐Acceptors for the Spectrophotometric Determination of Tranexamic Acid in Commercial Dosage Forms

Abstract

In this study, two simple, fast, accurate, and sensitive spectrophotometric methods have been developed for the determination of tranexamic acid in commercial dosage forms. These methods (A and B) are based on the reaction of tranexamic acid as n-electron donor with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as p-acceptors to give highly colored complex species that absorb maximally at 470 and 750 nm, respectively. Beer's law was obeyed in the concentration limit of 0.5 -10 mg/mL for tranexamic acid. The limit of detection (LOD) and limit of quantification (LOQ) were calculated and found to be 0.18 mg/mL and 0.60 mg/mL for method A and 0.12 mg/mL and 0.39 mg/mL for method B, respectively. A Job's plot of the absorbance versus the molar ratio of tranexamic acid to each of the acceptors under consideration indicated 1 : 1. The proposed methods were found to be rapid, accurate, precise, and sensitive for the determination of tranexamic acid in commercial dosage forms without interferences from common additives encountered.

Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms

“…Spectrophotometric techniques continue to be the most preferred methods for routine analytical work due to their simplicity and reasonable sensitivity with significant economical advantages. On the other hand, it is well known that p -benzoquinones such as 7,7,7,8-tetracyanoquinodimethane (TCNQ) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as π -electron acceptors often form highly colored electron-donor-acceptor (EDA) or charge transfer (CT) complexes with various donors which provides the possibility of determination of drugs by spectrophotometric methods [ 17 , 18 ]. In order to develop new simple, fast, and extraction-free spectrophotometric methods for the determination of alendronate sodium in pure and pharmaceutical dosage forms, we investigated quantitative reactions of alendronate sodium with organic π -acceptors like TCNQ and DDQ.…”