Utility of Common Marmoset (Callithrix jacchus) Embryonic Stem Cells in Liver Disease Modeling, Tissue Engineering and Drug Metabolism

Aravalli, Rajagopal N.; Steer, Clifford J.

doi:10.3390/genes11070729

Cited by 10 publications

(5 citation statements)

References 229 publications

(303 reference statements)

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“…However, their use in daily laboratory practice is still limited. In a review by Aravalli et al [ 119 ] a list of advantages and potential applications of CM ES cells and iPSCs in liver disease modeling, tissue engineering and drug metabolism was described, but no articles describing the use of CM cells were mentioned. Importantly, the use of CM ES cells and iPSCs for modeling viral infections is also limited.…”

Section: Marmoset Induced Pluripotent Cellsmentioning

confidence: 99%

Common Marmoset Cell Lines and Their Applications in Biomedical Research

Bayurova,

Zhitkevich,

Avdoshina

et al. 2023

Cells

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Common marmosets (Callithrix jacchus; CMs) are small New World primates widely used in biomedical research. Early stages of such research often include in vitro experiments which require standardized and well-characterized CM cell cultures derived from different tissues. Despite the long history of laboratory work with CMs and high translational potential of such studies, the number of available standardized, well-defined, stable, and validated CM cell lines is still small. While primary cells and immortalized cell lines are mostly used for the studies of infectious diseases, biochemical research, and targeted gene therapy, the main current applications of CM embryonic stem cells and induced pluripotent stem cells are regenerative medicine, stem cell research, generation of transgenic CMs, transplantology, cell therapy, reproductive physiology, oncology, and neurodegenerative diseases. In this review we summarize the data on the main advantages, drawbacks and research applications of CM cell lines published to date including primary cells, immortalized cell lines, lymphoblastoid cell lines, embryonic stem cells, and induced pluripotent stem cells.

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Section: Marmoset Induced Pluripotent Cellsmentioning

confidence: 99%

Common Marmoset Cell Lines and Their Applications in Biomedical Research

Bayurova,

Zhitkevich,

Avdoshina

et al. 2023

Cells

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“…Игрунки являются релевантными тестсистемами для изучения метаболизма лекарств и токсикологических исследований из-за сходства суперсемейств цитохрома P450 [29,30] этого вида животных и человека, что опосредует вероятную схожесть фармакокинетических и фармакодинамических характеристик широкого спектра лекарственных средств у двух видов.…”

Section: Original Articleunclassified

Variability of blood biochemical parameters and establishment of reference intervals in preclinical studies. Part 12: the common marmoset

Miroshnikov,

Sultanova,

Kovaleva

2023

Lab Anim Sci Rus

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The common marmosets (Callithrix jacchus) is currently widely used in preclinical studies. These animals are used in preclinical studies aimed at studying pathological conditions associated with the central nervous system, the immune response, the study of infectious and viral diseases, as well as metabolic disorders. The wide involvement of common marmosets in preclinical studies indicates the need for control and periodic monitoring of health. The aim of this study was to establish reference intervals of biochemical blood parameters of healthy mature common marmosets, which can be used as the basic values of animals in preclinical studies. The data obtained from 24 males and 24 females were analyzed. The age of males and females of common marmosets was 12 months, the average body weight was 350 g. Determination of biochemical parameters of all animals was carried out under the same conditions using generally accepted analytical methods. For the study, blood was used, which was taken from the lateral vena of the hind paw of animals. The following parameters were recorded in the blood serum of animals: creatinine, urea, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, triglycerides, total protein, albumin, glucose, creatine kinase, lactate dehydrogenase and total bilirubin. The obtained values were analyzed with other reference intervals found in the scientific literature. In general, the ranges of the considered indicators of both males and females were similar, but there were also differences. Thus, the upper limits of the calculated reference intervals of urea, aspartate aminotransferase, alanine aminotransferase, total bilirubin, creatine kinase and triglycerides were lower than similar literary values. According to such obtained ranges of values as total protein, albumin, glucose and lactate dehydrogenase, both similar and higher literary values were found. Differences in the obtained intervals of normal values with similar ranges from other publications may be associated with preanalytical, analytical and postanalytical features of the formulation of the analysis. Seasonality, conditions of keeping and nutrition of the marmosets are also important factors. That is why a serious aspect in preclinical research is the creation of reference intervals of healthy laboratory animals in each scientific center. The obtained intervals can help to avoid erroneous conclusions in the course of studying the safety of new therapeutic agents or modeling a pathological state.

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“…Over the past two decades, marmosets have been more frequently used in preclinical, toxicology, and safety assessment of drugs. 4-30…”

Section: Introductionmentioning

confidence: 99%

The Common Marmoset—Biomedical Research Animal Model Applications and Common Spontaneous Diseases

Han

2022

Toxicol Pathol

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Marmosets are becoming more utilized in biomedical research due to multiple advantages including (1) a nonhuman primate of a smaller size with less cost for housing, (2) physiologic similarities to humans, (3) translatable hepatic metabolism, (4) higher numbers of litters per year, (5) genome is sequenced, molecular reagents are available, (6) immunologically similar to humans, (7) transgenic marmosets with germline transmission have been produced, and (8) are naturally occurring hematopoietic chimeras. With more use of marmosets, disease surveillance over a wide range of ages of marmosets has been performed. This has led to a better understanding of the disease management of spontaneous diseases that can occur in colonies. Knowledge of clinical signs and histologic lesions can assist in maximizing the colony’s health, allowing for improved outcomes in translational studies within biomedical research. Here, we describe some basic husbandry, biology, common spontaneous diseases, and animal model applications for the common marmoset in biomedical research.

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Utility of Common Marmoset (Callithrix jacchus) Embryonic Stem Cells in Liver Disease Modeling, Tissue Engineering and Drug Metabolism

Cited by 10 publications

References 229 publications

Common Marmoset Cell Lines and Their Applications in Biomedical Research

Common Marmoset Cell Lines and Their Applications in Biomedical Research

Variability of blood biochemical parameters and establishment of reference intervals in preclinical studies. Part 12: the common marmoset

The Common Marmoset—Biomedical Research Animal Model Applications and Common Spontaneous Diseases

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