Utility of cord blood culture in early onset neonatal sepsis

Abstract

UCBC is a simple convenient method, which ensures culture of adequate volume of blood from newborns allowing effective early isolation of bacterial pathogens, especially in EONS.

Diagnostics for neonatal sepsis: current approaches and future directions

“…Another study evaluating 40 neonates with two or more risk factors for EOS found that, compared with peripheral venous samples, cord blood had 100% sensitivity and 95% specificity (27). Cord blood CRP, however, was negative in all 11 neonates who screened positive for sepsis (27).…”

“…review of 15 studies evaluating over 2,000 episodes of suspected neonatal infection identified interleukin-6 (IL-6) and PCT in cord blood as having high positive (9.47 and 5.72, respectively) and negative likelihood ratios (0.10 and 0.20, respectively) (22). Another study evaluating 40 neonates with two or more risk factors for EOS found that, compared with peripheral venous samples, cord blood had 100% sensitivity and 95% specificity (27). Cord blood CRP, however, was negative in all 11 neonates who screened positive for sepsis (27).…”

Calculator and Prediction Score for Early-onset Neonatal Sepsis in Asymptomatic Term Infant: A Determinant Model

“…19 The sensitivity of cord blood culture is 80-100% and specificity is 91-94%, while the positive and negative predictive value are 33-72% and 94-100%, respectively. 19,20 It is less invasive and painful, easier to preform, and a larger volume of blood is available compared with peripheal blood cultures. A good technique will reduce the risk of contamination.…”

Hemocultivos en recién nacidos: optimizando la toma de muestra y su rendimiento

“…La técnica de recolección de HC de cordón es crítica, pues existe alto riesgo de contaminación post parto vaginal 33,34 . Los principales beneficios que ofrece esta técnica son: • Obtención inmediata de la muestra, sin retrasar el diagnóstico y permitiendo rápidamente el inicio de antimicrobianos empíricos en niños con sospecha de sepsis precoz.…”

“…Se realizó una desinfección del extremo placentario con alcohol 70º y se recolectó una muestra de sangre de 2 ml, que fueron sembrados en una botella de HC aeróbico. La sensibilidad de este método en este estudio fue de 100% con una especificidad de 94,9% en comparación con los HC tomados en vena periférica 34 . Por otra parte, existen otros reportes que describen una sensibilidad un poco menor, cercanas a 80%, con especificidad de 91,4% comparadas con HC tomados por vía periférica 36 .…”