Utility of delayed gadolinium-enhanced MRI (dGEMRIC) for qualitative evaluation of articular cartilage of patellofemoral joint

Nojiri, Takehiro; Watanabe, Nobuyoshi; Namura, Takehiko; Narita, Wataru; Ikoma, Kazuya; Suginoshita, Takehiko; Takamiya, Hisatake; Komiyama, Hiroto; Ito, Hirotoshi; Nishimura, Tsunehiko; Kubo, Toshikazu

doi:10.1007/s00167-005-0013-6

Cited by 30 publications

(28 citation statements)

References 20 publications

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“…The diagnosis of damage in articular cartilage was possible in all 16 cases with radiographic KLG 1 on dGEMRIC, while the intensity changes were not found in 10 of 16 cases on Proton density Weighted Image (PDWI) 33 .…”

Section: Resultsmentioning

confidence: 96%

Systematic review of the concurrent and predictive validity of MRI biomarkers in OA

Hunter

Zhang

Conaghan

et al. 2011

Osteoarthritis and Cartilage

179

150

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SUMMARY Objective To summarize literature on the concurrent and predictive validity of MRI-based measures of osteoarthritis (OA) structural change. Methods An online literature search was conducted of the OVID, EMBASE, CINAHL, PsychInfo and Cochrane databases of articles published up to the time of the search, April 2009. 1338 abstracts obtained with this search were preliminarily screened for relevance by two reviewers. Of these, 243 were selected for data extraction for this analysis on validity as well as separate reviews on discriminate validity and diagnostic performance. Of these 142 manuscripts included data pertinent to concurrent validity and 61 manuscripts for the predictive validity review. For this analysis we extracted data on criterion (concurrent and predictive) validity from both longitudinal and cross-sectional studies for all synovial joint tissues as it relates to MRI measurement in OA. Results Concurrent validity of MRI in OA has been examined compared to symptoms, radiography, histology/pathology, arthroscopy, CT, and alignment. The relation of bone marrow lesions, synovitis and effusion to pain was moderate to strong. There was a weak or no relation of cartilage morphology or meniscal tears to pain. The relation of cartilage morphology to radiographic OA and radiographic joint space was inconsistent. There was a higher frequency of meniscal tears, synovitis and other features in persons with radiographic OA. The relation of cartilage to other constructs including histology and arthroscopy was stronger. Predictive validity of MRI in OA has been examined for ability to predict total knee replacement (TKR), change in symptoms, radiographic progression as well as MRI progression. Quantitative cartilage volume change and presence of cartilage defects or bone marrow lesions are potential predictors of TKR. Conclusion MRI has inherent strengths and unique advantages in its ability to visualize multiple individual tissue pathologies relating to pain and also predict clinical outcome. The complex disease of OA which involves an array of tissue abnormalities is best imaged using this imaging tool.

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Section: Resultsmentioning

confidence: 96%

Systematic review of the concurrent and predictive validity of MRI biomarkers in OA

Hunter

Zhang

Conaghan

et al. 2011

Osteoarthritis and Cartilage

179

150

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“…The abstracts of all 1879 studies were reviewed and 52 articles met the pre-determined inclusion and exclusion criteria. Fourteen level I, 7, 14, 16, 17, 27, 37, 40–43, 50, 72, 84, 85 13 level II 4, 10, 26, 28, 38, 39, 47, 55, 59, 74, 78, 80, 90 and 26 level III–V 5, 8, 12, 23, 29, 31–33, 35, 36, 44, 48, 49, 54, 60, 63–65, 69, 75, 81–83, 86, 93 studies were identified. For level I and II studies, Table 2 describes the breakdown of the number of articles that reported results regarding diagnostic performance of MRI compared to arthroscopy for grading of chondral involvement, reliability of grading between evaluators, MRI sequence performance, and involved articular cartilage surface or knee compartment.…”

Section: Resultsmentioning

confidence: 99%

The Clinical Utility and Diagnostic Performance of Magnetic Resonance Imaging for Identification of Early and Advanced Knee Osteoarthritis

et al. 2011

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Background Current diagnostic strategies for detection of structural articular cartilage abnormalities, the earliest structural signs of osteoarthritis, often do not capture the condition until it is too far advanced for the most potential benefit of non-invasive interventions. Purpose Systematically review the literature relative to the following questions: (1) Is MRI a valid, sensitive, specific, accurate and reliable instrument to identify knee articular cartilage abnormalities compared to arthroscopy? (2) Is MRI a sensitive tool that can be utilized to identify early cartilage degeneration? Study Design Systematic Review Methods A systematic search was performed in November 2010 using PubMed MEDLINE (from 1966), CINAHL (from 1982), SPORTDiscus (from 1985), and SCOPUS (from 1996) databases. Results Fourteen level I and 13 level II studies were identified that met inclusion criteria and provided information related to diagnostic performance of MRI compared to arthroscopic evaluation. The diagnostic performance of MRI demonstrated a large range of sensitivities, specificities, and accuracies. The sensitivity for identifying articular cartilage abnormalities in the knee joint was reported between 26–96%. Specificity and accuracy was reported between 50–100% and 49–94%, respectively. The sensitivity, specificity, and accuracy for identifying early osteoarthritis were reported between 0–86%, 48–95%, and 5–94%, respectively. As a result of inconsistencies between imaging techniques and methodological shortcomings of many of the studies, a meta-analysis was not performed and it was difficult to fully synthesize the information to state firm conclusions about the diagnostic performance of MRI. Conclusions There is evidence in some MRI protocols that MRI is a relatively valid, sensitive, specific, accurate, and reliable clinical tool for identifying articular cartilage degeneration. Due to heterogeneity of MRI sequences it is not possible to make definitive conclusions regarding its global clinical utility for guiding diagnosis and treatment strategies. Clinical Relevance Traumatic sports injuries to the knee may be significant precursor events to early onset of posttraumatic osteoarthritis. MRI may aid in early identification of structural injuries to articular cartilage as evidenced by articular cartilage degeneration grading.

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“…Overall, T 1,Gd is lower with preradiographic damage [47] and with radiographic cartilage damage and OA [43,46,48] when compared with healthy joints. T 1,Gd also correlates with radiographic scores of OA [43,44], joint alignment [43,45,101] and measures of joint pain [45]. Additionally, dGEMRIC has been shown to be sensitive to pre-radiographic damage [49].…”

Section: T 1 Mapping and Delayed Gadolinium-enhanced Magnetic Resonanmentioning

confidence: 98%

“…A significant thrust in much of the qMRI literature is towards the correlation of various qMRI values to biochemical content, typically determined in explants through histology [14,26 -30,41,42,50-52,107], and to pain score or OA grade [39,43,44,48,54,56,57,90,126]. A number of groups have applied qMRI techniques to evaluate the differences between cartilage in normal subjects and patients with higher OA risk [43 -45,87,101].…”

Section: Shifting the Paradigm Towards Diagnosis Of Osteoarthritis Inmentioning

confidence: 99%

Probing articular cartilage damage and disease by quantitative magnetic resonance imaging

Chan

Neu

2013

J. R. Soc. Interface.

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Osteoarthritis (OA) is a debilitating disease that reflects a complex interplay of biochemical, biomechanical, metabolic and genetic factors, which are often triggered by injury, and mediated by inflammation, catabolic cytokines and enzymes. An unmet clinical need is the lack of reliable methods that are able to probe the pathogenesis of early OA when disease-rectifying therapies may be most effective. Non-invasive quantitative magnetic resonance imaging (qMRI) techniques have shown potential for characterizing the structural, biochemical and mechanical changes that occur with cartilage degeneration. In this paper, we review the background in articular cartilage and OA as it pertains to conventional MRI and qMRI techniques. We then discuss how conventional MRI and qMRI techniques are used in clinical and research environments to evaluate biochemical and mechanical changes associated with degeneration. Some qMRI techniques allow for the use of relaxometry values as indirect biomarkers for cartilage components. Direct characterization of mechanical behaviour of cartilage is possible via other specialized qMRI techniques. The combination of these qMRI techniques has the potential to fully characterize the biochemical and biomechanical states that represent the initial changes associated with cartilage degeneration. Additionally, knowledge of in vivo cartilage biochemistry and mechanical behaviour in healthy subjects and across a spectrum of osteoarthritic patients could lead to improvements in the detection, management and treatment of OA.

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Utility of delayed gadolinium-enhanced MRI (dGEMRIC) for qualitative evaluation of articular cartilage of patellofemoral joint

Cited by 30 publications

References 20 publications

Systematic review of the concurrent and predictive validity of MRI biomarkers in OA

Systematic review of the concurrent and predictive validity of MRI biomarkers in OA

The Clinical Utility and Diagnostic Performance of Magnetic Resonance Imaging for Identification of Early and Advanced Knee Osteoarthritis

Probing articular cartilage damage and disease by quantitative magnetic resonance imaging

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