Utility of FDG PET/CT in the Characterization of Sinonasal Neoplasms: Analysis of Standardized Uptake Value Parameters

Öztürk, Kerem; Gencturk, Mehmet; Caicedo-Granados, Emiro; Li, Faqian; Cayci, Zuzan

doi:10.2214/ajr.18.19501

Cited by 13 publications

(30 citation statements)

References 24 publications

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“…A meta-analysis including eight studies with 1080 patients showed that there was a significant relationship between high SUVmax and poor prognosis, however, the relationship was not significant between SUVmean and poor prognosis 55. This may be explained by that when using the SUVmean, it is more likely for us to neglect the larger SUVs among the regions of interest 55, 59. In this study, SUVmean was not associated with survival in patients of training cohort, validation and total cohorts, respectively.…”

Section: Discussionmentioning

confidence: 99%

Radiomic signature of¹⁸F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits

Jiang¹,

Yuan²,

Lv³

et al. 2018

Theranostics

124

122

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We aimed to evaluate whether radiomic feature-based fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging signatures allow prediction of gastric cancer (GC) survival and chemotherapy benefits.Methods: A total of 214 GC patients (training (n = 132) or validation (n = 82) cohort) were subjected to radiomic feature extraction (80 features). Radiomic features of patients in the training cohort were subjected to a LASSO cox analysis to predict disease-free survival (DFS) and overall survival (OS) and were validated in the validation cohort. A radiomics nomogram with the radiomic signature incorporated was constructed to demonstrate the incremental value of the radiomic signature to the TNM staging system for individualized survival estimation, which was then assessed with respect to calibration, discrimination, and clinical usefulness. The performance was assessed with concordance index (C-index) and integrated Brier scores.Results: Significant differences were found between the high- and low-radiomic score (Rad-score) patients in 5-year DFS and OS in training and validation cohorts. Multivariate analysis revealed that the Rad-score was an independent prognostic factor. Incorporating the Rad-score into the radiomics-based nomogram resulted in better performance (C-index: DFS, 0.800; OS, 0.786; in the training cohort) than TNM staging system and clinicopathologic nomogram. Further analysis revealed that patients with higher Rad-scores were prone to benefit from chemotherapy.Conclusion: The newly developed radiomic signature was a powerful predictor of OS and DFS. Moreover, the radiomic signature could predict which patients could benefit from chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Radiomic signature of¹⁸F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits

Jiang¹,

Yuan²,

Lv³

et al. 2018

Theranostics

124

122

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“…Patients were staged based on the American Joint Committee on Cancer criteria (AJCC), 11 and the University of California Los Angeles staging system 12 was used for olfactory neuroblastomas (ONBs). The primary tumor anatomic subsite and the extent of the invasion were mostly determined by evaluating pretreatment 18 F-FDG PET/CT imaging. CT and MRI scans, physical examination findings, operative reports, and surgical pathology reports were reviewed in cases where the tumor anatomic subsite and extent of invasion could not be determined accurately.…”

Section: Patient Populationmentioning

confidence: 99%

“…18 F-FDG PET/CT imaging. 18 F-FDG PET/CT scans conducted at our institution were performed following routine preparation, involving fasting for six hours. Patients were required to have blood glucose levels of <180 mg/dL before the scan.…”

Section: Techniquementioning

confidence: 99%

“…9 Therefore, noninvasive imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), and 18-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT), may possibly play an important role in obtaining information about the biological properties of these tumors. 10 To our knowledge, a comprehensive description of the imaging appearance of sinonasal SRBCTs using various imaging methods including diffusion-weighted imaging (DWI) and 18 F-FDG PET/CT has not been reported in the literature. The aim of this study was to determine whether sinonasal SRBCTs have distinct imaging features on CT, 18 F-FDG PET/CT, and MRI.…”

Section: Introductionmentioning

confidence: 99%

“…10 To our knowledge, a comprehensive description of the imaging appearance of sinonasal SRBCTs using various imaging methods including diffusion-weighted imaging (DWI) and 18 F-FDG PET/CT has not been reported in the literature. The aim of this study was to determine whether sinonasal SRBCTs have distinct imaging features on CT, 18 F-FDG PET/CT, and MRI.…”

Section: Introductionmentioning

confidence: 99%

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Positron emission computed tomography and magnetic resonance imaging features of sinonasal small round blue cell tumors

et al. 2019

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Aim The sinonasal tract hosts numerous types of undifferentiated neoplasms, having small round cell morphology. The aim of this study was to determine whether sinonasal small round blue cell tumors (SRBCT) have distinct imaging features on computed tomography (CT), magnetic resonance imaging (MRI), and 18-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT. Methods Seventy-three patients (43 male; Mage = 61.2 years) with histopathologically proven sinonasal SRBCT were retrospectively reviewed. Imaging features of SRBCTs including location, maximum dimension, margin characteristics, presence of calcification, sclerotic bone changes, intratumoral necrosis, tumor extension, bone destruction, bone remodeling, perineural spread, T1- and T2-weighted MRI signal intensity, qualitative features on diffusion-weighted imaging and 18F-FDG PET/CT, and pattern of contrast enhancement were analyzed using Fisher’s exact test or the chi-square test. The maximum standardized uptake values (SUVmax) and apparent diffusion coefficient (ADCmean) values of SRBCT were compared by utilizing the Kruskal–Wallis test. Results There was a significant difference between SRBCT type regarding the tumor location ( p = 0.006), 18F-FDG uptake pattern ( p = 0.006), involvement of the orbit ( p = 0.016) and pterygopalatine fossa ( p = 0.043), the presence of perineural spread ( p < 0.001), bone destruction ( p = 0.034), and intratumoral necrosis ( p = 0.022). Bone destruction and necrosis were more common in rhabdomyosarcoma. Perineural spread was common in sinonasal adenoid cystic carcinoma (ACC). Qualitative 18F-FDG uptake features as well as tumor location were significantly different between sinonasal ACC and sinonasal undifferentiated carcinoma. The ADCmean and SUVmax values were not statistically different between SRBCT types. Conclusions Sinonasal SRBCTs have numerous distinct imaging features on CT, MRI, and 18F-FDG PET/CT that could be useful in the differentiation between lesions when the histopathologic diagnosis is inconclusive.

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Utility of FDG PET/CT in the Characterization of Sinonasal Neoplasms: Analysis of Standardized Uptake Value Parameters

Cited by 13 publications

References 24 publications

Radiomic signature of¹⁸F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits

Radiomic signature of¹⁸F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits

Positron emission computed tomography and magnetic resonance imaging features of sinonasal small round blue cell tumors

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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Utility of FDG PET/CT in the Characterization of Sinonasal Neoplasms: Analysis of Standardized Uptake Value Parameters

Cited by 13 publications

References 24 publications

Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits

Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits

Positron emission computed tomography and magnetic resonance imaging features of sinonasal small round blue cell tumors

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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Radiomic signature of¹⁸F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits

Radiomic signature of¹⁸F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits