Utility of ferritin and inflammatory biomarkers in the diagnosis of different stages of breast cancer

George, Anila; Bobby, Zachariah; Dubashi, Biswajit

doi:10.15537/smj.2021.42.8.20210244

Cited by 6 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concerning C-reactive protein (CRP), Figure (3) shows a significant increase (p<0.05) in serum CRP concentration in patients with breast cancer. This is consistent with previous research [24,25,26]. CRP is produced predominantly by liver hepatocytes but also by macrophages, smooth muscle cells, endothelial cells, lymphoid cells, and adipocytes [6].…”

Section: Resultssupporting

confidence: 93%

Evaluation of the Serum Levels of Interleukin-6, Interleukin-10, and C-Reactive Protein in Iraqi Women with Breast Cancer

Ibraheem Muhesin,

Abbas Hadi

2023

Kufa Jour. Bio.

View full text Add to dashboard Cite

Breast cancer is the most prevalent form of cancer in women and is the leading cause of global cancer-related mortality. The study aimed to assess the changes in some serum biomarkers linked to immunity responses in Iraqi breast cancer patients and understand their multifaceted role in the disease's progression. The current investigation comprised a cohort of 55 women diagnosed with breast cancer and a control group of 45 healthy participants. The levels of interleukin-6 (IL-6), interleukin-10 (IL-10), and C-reactive protein (CRP) were estimated in the serum of breast cancer patients. The results showed that patients with breast cancer had a significant increase (p<0.05) in IL-6, IL-10, and CRP serum concentrations as compared to healthy women. These findings give support to the evidence suggesting that these markers may play an essential role in the progression of breast cancer.

show abstract

Section: Resultssupporting

confidence: 93%

Evaluation of the Serum Levels of Interleukin-6, Interleukin-10, and C-Reactive Protein in Iraqi Women with Breast Cancer

Ibraheem Muhesin,

Abbas Hadi

2023

Kufa Jour. Bio.

View full text Add to dashboard Cite

show abstract

“…The role of hepcidin in promoting iron uptake by macrophages during inflammatory processes has been documented. 12 Another study indicates elevated serum ferritin levels due to elevated transferrin receptors on malignant clones of leukemic cells. Additionally, high cell destruction rates reveal ferritin carriage and raise serum levels, which are also consistent with the study results by Albert and Schmidt.…”

Section: Discussionmentioning

confidence: 99%

The impact of reproductive hormone changes on the immune response of patients with leukemia

Thabit,

Almzaiel,

Kadhim

et al. 2023

Anaesth. pain intensive care

View full text Add to dashboard Cite

Background & Objective: Leukemias have been associated with various immune and endocrine changes. Several studies have established a correlation between an imbalance in pituitary hormones and sex steroids and the initiation of illness in either one or both genders. The hormone changes can affect normal physiological homogeneity of the human body, thus effecting health as well as the course of unrelated diseases. We aimed to investigate the influence of alterations in reproductive hormones on the immune response of individuals diagnosed with leukemia. Material and Methods: In this case-control study, a total of 130 subjects, out of which 80 patients were known cases with hematological cancer, were enrolled at the Medical City Department/Hematology Center in Baghdad, Iraq, from February-October 2022. Out of 80 patients diagnosed with leukemia, 45 patients had acute myeloid leukemia (AML), and 35 patients had acute lymphoblastic leukemia (ALL). The study involved 50 healthy controls. Estradiol (E2), triiodothyronine (T3), follicle-stimulating hormone (FSH), and progesterone levels were measured using both ELISA and the immunofluorescence assay method in all participants. C-reactive protein (CRP), ferritin, and neutrophil-to-lymphocyte ratio (NLR) was also determined. Results: The findings of the study demonstrated a significant elevation in the levels of CRP, ferritin (P < 0.001), and NLR (P = 0.01) in the individual’s group when compared to the control group. Serum progesterone was increased in patients diagnosed with AML and ALL in comparison to the control group (P = 0.01). FSH was elevated (P = 0.02) in AML and decreased in ALL. This difference was found to be statistically significant. The levels of T3 and E2 were found to be significantly reduced in both AML and ALL patients when compared to the control group (P = 0.1 and 0.02 respectively). Abbreviations: ACTH - Adrenocorticotropic Hormone; ALL - Acute Lymphoblastic Leukemia; AML - Acute Myeloid Leukemia; E2 – Estradiol; LH - Luteinizing Hormone NLR - Neutrophil-To-Lymphocyte Ratio Conclusions: The findings of the study offer empirical support for the impact of hormones on the immune response in leukemia pathogenesis. Key words: Leukemia; Reproductive Hormones; Immune Response Citation: Thabit JA, Almzaiel AJ, Kadhim MI, Alrufaie MA. The impact of reproductive hormone changes on the immune response of patients with leukemia. Anaesth. pain intensive care 2023;27(5):585−591; DOI: 10.35975/apic.v27i5.2317 Received: August 06, 2023; Reviewed: August 12, 2023; Accepted: August 12, 2023

show abstract

“…Lately, several studies have correlated the increased amounts of this protein with the higher risk of developing oncologic disorders, as well as prognosing the positive or negative advance of the disease. Regarding breast cancer, increased sFT has been positively associated with the increased incidence of the disease [89], and even with the severity of cancer progression [90]. Increased levels of FT are also a good indication of an escalated risk of pancreatic cancer development [91].…”

Section: Role Of Circulating Ferritin In Health and Diseasementioning

confidence: 99%

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Fonseca,

Ramos,

Gomes

et al. 2023

Molecules

View full text Add to dashboard Cite

The diagnosis of iron disturbances usually includes the evaluation of serum parameters. Serum iron is assumed to be entirely bound to transferrin, and transferrin saturation—the ratio between the serum iron concentration and serum transferrin—usually reflects iron availability. Additionally, serum ferritin is commonly used as a surrogate of tissue iron levels. Low serum ferritin values are interpreted as a sign of iron deficiency, and high values are the main indicator of pathological iron overload. However, in situations of inflammation, serum ferritin levels may be very high, independently of tissue iron levels. This presents a particularly puzzling challenge for the clinician evaluating the overall iron status of the patient in the presence of an inflammatory condition. The increase in serum ferritin during inflammation is one of the enigmas regarding iron metabolism. Neither the origin, the mechanism of release, nor the effects of serum ferritin are known. The use of serum ferritin as a biomarker of disease has been rising, and it has become increasingly diverse, but whether or not it contributes to controlling the disease or host pathology, and how it would do it, are important, open questions. These will be discussed here, where we spotlight circulating ferritin and revise the recent clinical and preclinical data regarding its role in health and disease.

show abstract

Utility of ferritin and inflammatory biomarkers in the diagnosis of different stages of breast cancer

Cited by 6 publications

References 28 publications

Evaluation of the Serum Levels of Interleukin-6, Interleukin-10, and C-Reactive Protein in Iraqi Women with Breast Cancer

Evaluation of the Serum Levels of Interleukin-6, Interleukin-10, and C-Reactive Protein in Iraqi Women with Breast Cancer

The impact of reproductive hormone changes on the immune response of patients with leukemia

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Contact Info

Product

Resources

About