Utility of flow cytometry in subtyping composite and sequential lymphoma

Siebert, James D.; Mulvaney, Debra A.; Vukov, Allen M.; Knost, James A.; King, David E.; Craig, Fiona E.

doi:10.1002/(sici)1098-2825(1999)13:5<199::aid-jcla1>3.0.co;2-w

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…6,12 As illustrated in case 1, the absence of immunoglobulin expression of the FL population and the lack of detectable CD5 in the CLL population can potentially result in the diagnostic pitfall of interpreting the flow cytometry data as a single B-cell population with partial CD10, sIgλCD20, and CD23 expression. However, the exclusion between surface immunoglobulin λ and CD10 and the almost total lack of coexpression between CD20 (moderate intensity) and CD23 should raise the suspicion of a second neoplastic B-cell population.…”

Section: Discussionmentioning

confidence: 99%

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma Are Biclonal Lymphomas

Boiocchi¹,

Witter

He³

et al. 2012

Am J Clin Pathol

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Section: Discussionmentioning

confidence: 99%

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma Are Biclonal Lymphomas

Boiocchi¹,

Witter

He³

et al. 2012

Am J Clin Pathol

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“…Among the 49 patients with multiple lymphomas, five (10.2%) were composite/discordant lymphomas (Table 1), of those, four were "composite lymphoma" (Kim 1993) with a combination of DLBCL and ATL or other T-cell lymphoma in a single tissue, and the rest one was "discordant lymphoma" (Acker et al 1983) with a combination of FL in the spleen and Waldenström macroglobulinemia in the bone marrow. The remaining 44 patients (89.8%) were "sequential lymphoma" (Siebert et al 1999) of various combinations of lymphoma types on different dates (Tables 2 and 3). The frequent combination of the first/second types of lymphoma were MZL/DLBCL (n = 4), DLBCL/ATL (n = 3), and WM or LPL/DLBCL (n = 3).…”

Section: Resultsmentioning

confidence: 99%

“…However, as the overall prognosis of patients with NHL has improved, the occurrence of multiple distinctive histologic types of lymphoma in a single patient has become noticeable recently. Such patients developing subsequent different histological types of lymphomas are known to be diagnosed as sequential lymphoma (Siebert et al 1999), discordant lymphoma (Acker et al 1983), or transformed lymphoma (Al-Mansour et al 2010). Furthermore, patients of more than one histological type of lymphoma simultaneously in a single tissue are known as composite lymphoma (Kim 1993).…”

Section: Introductionmentioning

confidence: 99%

Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study

Niino

Luong

Maeda

et al. 2021

Tohoku J. Exp. Med.

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The development of multiple histologic types of lymphoma in a single patient has been sporadically reported as sequential or composite lymphoma. However, the incidence pattern of such patients has been rarely evaluated in a large population-based setting. We investigated the incidence of sequential or composite lymphoma based on 11,174 lymphoma records from a population-based cancer registry between 1985 -2012 in Nagasaki Prefecture, Japan. We identified 99 lymphoma records were of 49 independent patients other than relapse. The prevalence of the sequential or composite lymphomas in a single patient was 0.44% (95% confidence interval [95% CI], 0.32-0.56%) without sex difference. Among the 49 patients, five (10.2%) were composite/discordant lymphoma. The most frequent "composite lymphoma" was a combination of diffuse large B-cell lymphomas (DLBCL) and adult T-cell leukemia (n = 3). A case of "discordant lymphoma" was a combination of follicular lymphoma on spleen and Waldenström macroglobulinemia on bone marrow. The rest of the patients (n = 44, 89.8% of all composite lymphoma) were "sequential lymphoma" with various combination of lymphoma subtypes on different dates. The major combination of the sequential lymphoma was DLBCL after marginal zone lymphomas (n = 4). In the era of improved survival of lymphoma patients, hematologists should be aware of the development of additional lymphomas.

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“…Several case reports of biclonal or composite B‐cell lymphomas have been published . The reported overall incidence of B‐cell chronic LPDs presenting with more than one aberrant population in one larger series ( n = 477) studied by FCM was approximately 5% .…”

Section: Lymphoproliferative Disorders With More Than One Aberrant Cementioning

confidence: 99%

Immunophenotyping of selected hematologic disorders – focus on lymphoproliferative disorders with more than one malignant cell population

Porwit

2013

Int J Lab Hematology

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Summary Currently, clinical laboratories face increasing demand for flow cytometry testing combined with limited funding. Therefore, many laboratories search for panels that would provide sufficient immunophenotyping information and meet economical requirements. At the Flow Cytometry Laboratory, University Health Network, Toronto, ON, Canada, we apply two 10‐color tubes of surface markers for diagnosis of lymphoproliferative disorders (LPDs). These tubes contain most of the mandatory B‐ and T‐cell markers according to European Leukemia Net (http://www.leukemia-net.org) recommendations. The B‐cell‐oriented panel includes the following antibodies: Kappa‐FITC/lambda‐PE/CD19‐ECD/CD38‐PC5.5/CD20‐PC7/CD34‐APC/CD23 APC‐AF700/CD10 APC‐AF750/CD5‐PB/CD45‐KO. A different combination is applied to detect cytoplasmic Ig light chain expression and aberrant immunophenotype of plasma cells. The T‐cell panel allows enumeration of various T‐ and NK‐cell subsets: CD57‐FITC/CD11c‐PE/CD8‐ECD/CD3‐PC5.5/CD2‐PC7/CD56‐APC/CD7‐APC‐AF700/CD4‐APC‐AF750/CD5‐PB/CD45‐KO. The reported overall incidence of B‐cell chronic LPDs presenting with more than one aberrant population is approximately 5%. Multicolor analysis facilitates the detection of multiple aberrant populations in the same sample because expression of multiple antigens can be studied simultaneously in each defined population. Examples of LPDs with multiple aberrant populations are presented.

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Utility of flow cytometry in subtyping composite and sequential lymphoma

Cited by 10 publications

References 14 publications

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma Are Biclonal Lymphomas

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma Are Biclonal Lymphomas

Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study

Immunophenotyping of selected hematologic disorders – focus on lymphoproliferative disorders with more than one malignant cell population

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