Utility of fluorodeoxyglucose positron emission tomography/computed tomography for early diagnosis and evaluation of disease activity of relapsing polychondritis: a case series and literature review

Yamashita, Hiroyuki; Takahashi, Hiroyuki; Kubota, Keiichi; Ueda, Yoshimichi; Ozaki, Takashi; Yorifuji, Hideki; Bannai, Ei; Minamimoto, Ryogo; Morooka, Miyako; Miyata, Yoko; Okasaki, Momoko; Takahashi, Yuko; Kaneko, Hiroshi; Kano, Toshikazu; Matsubara, Akio

doi:10.1093/rheumatology/keu147

Cited by 67 publications

(51 citation statements)

References 30 publications

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“…The emerging role of nuclear medicine based imaging has been a subject of interest and has a potential role in the diagnosis and evaluation of disease activity in RP due to its ability to identify subclinical lesions prior to the onset of frank symptoms [26]. …”

Section: Discussionmentioning

confidence: 99%

Relapsing polychondritis: clinical presentations, disease activity and outcomes

Sharma

Law

Bambery

et al. 2014

Orphanet J Rare Dis

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BackgroundRelapsing polychondritis is a rare disease characterised by inflammation of cartilaginous and proteoglycan rich structures. As there are only a few published single centre case series from all across the world, we describe our experience with 26 patients at a tertiary centre in north India.MethodsA retrospective study with all patients meeting Damiani and Levine’s modification of McAdam’s diagnostic criteria. Clinical details, investigations, disease activity assessment [(Relapsing Polychondritis Disease Activity Index (RPDAI)], treatment and outcomes were recorded.ResultsTen men and sixteen women (median age 45 years) met the diagnostic criteria. Auricular chondritis (96%), arthritis (54%), hearing impairment (42%), ocular (42%), dermal (26%), cardiovascular (11%) and laryngotracheal involvement (11%) characterized the clinical presentations. The median RPDAI was 31 (range 9-66). Two patients died during observation. Overall survival was 92.3% (median survival 13.5 years).ConclusionsApart from reduced laryngotracheal involvement, RP in India was clinically similar to recorded patterns elsewhere.

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Section: Discussionmentioning

confidence: 99%

Relapsing polychondritis: clinical presentations, disease activity and outcomes

Sharma

Law

Bambery

et al. 2014

Orphanet J Rare Dis

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“…However, tracheobronchial luminal narrowing is not specific to RPC, and other causes such as infection or amyloidosis should be considered . Fluorine‐18 fluorodeoxyglucose plus PET/CT (positron emission tomography with multislice helical computed tomography) has been proven to be a useful radiological tool for assessing early organ involvement and determining the extent of inflammation before and after treatment …”

Section: Discussionmentioning

confidence: 99%

Relapsing polychondritis, an underestimated dermatological urgency: case report and literature review

et al. 2017

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“…A CT scan is useful for evaluation of the tracheobronchial wall for diagnosis of RP [2]. Bone scintigraphy and positron emission tomography (PET) are also helpful in the diagnosis of RP [10].…”

Section: Discussionmentioning

confidence: 99%

A Case of Relapsing Polychondritis Successfully Treated with Combination of a Glucocorticoid and Cyclosporine

Takahashi¹,

Inoue²,

Sadamatsu³

et al. 2015

IJCM

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Relapsing polychondritis is a rare cartilaginous inflammatory disease affecting the external ear, nose, peripheral joints and tracheobronchial tree. It is characterized by recurrent inflammation and degeneration of cartilage and connective tissue. A 72-year-old man complained of dyspnea, cough and wheezing for 2 months. Diffuse wall thickening and narrowing from the trachea to segmental bronchus were seen on chest CT. Tracheostomy was performed in order to avoid asphyxia, and he was diagnosed as relapsing polychondritis on the basis of pathology evaluation of a tracheal biopsy specimen. He was treated with high doses of a glucocorticoid, with which his symptoms improved. However, the cough and wheezing recurred after tapering of the glucocorticoid. His symptoms thereafter were improved by combination of the glucocorticoid with cyclosporine. The immunosuppressive agent provided effective treatment for glucocorticoid-resistant relapsing polychondritis.

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Utility of fluorodeoxyglucose positron emission tomography/computed tomography for early diagnosis and evaluation of disease activity of relapsing polychondritis: a case series and literature review

Abstract: FDG-PET/CT is a potentially powerful tool for the early diagnosis of RPC, especially in patients without easily biopsied organ involvement. This modality also facilitates evaluation of disease extent and disease activity during treatment.

Cited by 67 publications

References 30 publications

Relapsing polychondritis: clinical presentations, disease activity and outcomes

Relapsing polychondritis: clinical presentations, disease activity and outcomes

Relapsing polychondritis, an underestimated dermatological urgency: case report and literature review

A Case of Relapsing Polychondritis Successfully Treated with Combination of a Glucocorticoid and Cyclosporine

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