Utility of fresh egg skin prick test and egg yolk specific immunoglobulin E for outgrowth

Uncuoğlu, Ayşen; Şimşek, Işıl Eser; Çöğürlü, Müjde Tuba; Baydemır, Canan; Aydoğan, Metin

doi:10.1016/j.anai.2020.05.032

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…The systematic search identified 1494 unique records. A total of 149 studies 31‐178 were included after application of our predefined eligibility criteria. Figure 1 illustrates the PRISMA meta‐analyses flowchart for the study screening and selection process.…”

Section: Resultsmentioning

confidence: 99%

“…We included 35 studies 33,34,41,43,49,58,59,66,70,72,76,80,82,86,92,95,103,116,124,126,127,129,131,135,140,144,150,154,155,156,159,164,166,170,178 on the accuracy of diagnostic tests for HE allergy. For meta-analyses, tests were divided into raw, cooked and baked HE allergies.…”

Section: Hen's Egg Allergymentioning

confidence: 99%

“…For cooked HE allergy, 6 studies on SPT to EW, 33,80,82,116,155,166 4 on SPP with raw EW, 33,80,124,166 14 on sIgE to EW , 33,43,72,80,86,95,116,126,129,150,155,166,170 7 on ovomucoid-sIgE 33,34,43,72,116,140,170 and 3 on ovalbumin-sIgE 33,43,170 met the inclusion criteria. SPP 33,80,124,166 was highly sensitive for cooked HE allergy diagnosis with pooled sensitivity of 94% and specificity of 66% at the 6 mm cut-off. SPT to EW 33,80,82,116,155,166 showed pooled sensitivity of 68% with a specificity of 77%.…”

Section: Hen's Egg Allergymentioning

confidence: 99%

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Systematic review and meta‐analyses on the accuracy of diagnostic tests for IgE‐mediated food allergy

Riggioni,

Ricci,

Moya

et al. 2023

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) is updating the Guidelines on Food Allergy Diagnosis. We aimed to undertake a systematic review of the literature with meta‐analyses to assess the accuracy of diagnostic tests for IgE‐mediated food allergy. We searched three databases (Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID)) for diagnostic test accuracy studies published between 1 October 2012 and 30 June 2021 according to a previously published protocol (CRD42021259186). We independently screened abstracts, extracted data from full texts and assessed risk of bias with QUADRAS 2 tool in duplicate. Meta‐analyses were undertaken for food‐test combinations for which three or more studies were available. A total of 149 studies comprising 24,489 patients met the inclusion criteria and they were generally heterogeneous. 60.4% of studies were in children ≤12 years of age, 54.3% were undertaken in Europe, ≥95% were conducted in a specialized paediatric or allergy clinical setting and all included oral food challenge in at least a percentage of enrolled patients, in 21.5% double‐blind placebo‐controlled food challenges. Skin prick test (SPT) with fresh cow's milk and raw egg had high sensitivity (90% and 94%) for milk and cooked egg allergies. Specific IgE (sIgE) to individual components had high specificity: Ara h 2‐sIgE had 92%, Cor a 14‐sIgE 95%, Ana o 3‐sIgE 94%, casein‐sIgE 93%, ovomucoid‐sIgE 92/91% for the diagnosis of peanut, hazelnut, cashew, cow's milk and raw/cooked egg allergies, respectively. The basophil activation test (BAT) was highly specific for the diagnosis of peanut (90%) and sesame (93%) allergies. In conclusion, SPT and specific IgE to extracts had high sensitivity whereas specific IgE to components and BAT had high specificity to support the diagnosis of individual food allergies.

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Section: Resultsmentioning

confidence: 99%

Section: Hen's Egg Allergymentioning

confidence: 99%

Section: Hen's Egg Allergymentioning

confidence: 99%

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Systematic review and meta‐analyses on the accuracy of diagnostic tests for IgE‐mediated food allergy

Riggioni,

Ricci,

Moya

et al. 2023

Allergy

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“…However, its reliability is questionable and differs between foods. In peanuts, egg, tree nuts, and fruits, the FF SPT gave more reliable results with sensitivity and specificity at least as good as the CE [ 8 , 9 , 13 ]. The current study aims to assess the advantages and drawback of each SPT method, and give the physician opportunity to examine their current practice.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies tried to define the wheal size that can predict an allergic reaction during OFC [4][5][6][7][8]. It is believed that SPT with FF is more predictive than that performed with CE [6,11,12].…”

Section: Introductionmentioning

confidence: 99%

Cow’s milk allergy skin tests: fresh milk, commercial extracts, or both?

Lachover‐Roth

Giorno²,

Hornik-Lurie³

et al. 2023

Allergy Asthma Clin Immunol

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Background The diagnosis of food allergy is based on a history of immediate allergic reaction following food ingestion, and skin prick test (SPT) demonstrating sensitization with commercial extracts (CE) or fresh food (FF). For most food allergens, the SPT with FF is considered more accurate and predictive. Regarding cow’s milk, the results are inconclusive. This retrospective study aimed to evaluate the accuracy of SPT with fresh milk compared to CE (cow’s milk and casein) for evaluation of cow’s milk allergy (CMA). Methods This study summarized the medical records of children, diagnosed with CMA. The data include demographics, skin tests and oral food challenge results, as well as atopic comorbidities. Results Records of 698 patients with the diagnosis of CMA were reviewed, 388 fulfilled the inclusion criteria. Overall, 134 patients (34.54%) had an additional atopic disease. The SPT wheal size with fresh milk was significantly larger than with CE (cow's milk and casein) at first evaluation or before oral food challenge (OFC). Combination of SPT results (CE and FF) gave the maximal odds ratio for reaction during OFC and SPT with fresh milk alone gave the minimal OR (34.18 and 4.74, respectively). Conclusions SPT with CE for CMA evaluation is more reliable than SPT performed with fresh milk. In patients suspected of having IgE-mediated CMA, before deciding on performing OFC, it is advised to perform SPT with at least two different extracts, and always include casein. Fresh milk can serve as a backup if commercial extracts are not available. In cases that the SPT with fresh milk is 3 mm or less, there is 93.3% chance that the OFC will pass without reaction. Trial registration This study protocol was reviewed and approved by the Ethics Committee of Meir Medical Center, IRB Number 0083-18 MMC.

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Food Allergy Evaluation for Dermatologic Disorders

Brar¹

2021

Immunology and Allergy Clinics of North America

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Utility of fresh egg skin prick test and egg yolk specific immunoglobulin E for outgrowth

Cited by 7 publications

References 20 publications

Systematic review and meta‐analyses on the accuracy of diagnostic tests for IgE‐mediated food allergy

Systematic review and meta‐analyses on the accuracy of diagnostic tests for IgE‐mediated food allergy

Cow’s milk allergy skin tests: fresh milk, commercial extracts, or both?

Food Allergy Evaluation for Dermatologic Disorders

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