Utility of High-Frequency Ultrasound

Lucas, Valentina; Burk, Ruth S.; Creehan, Sue; Grap, Mary Jo

doi:10.1097/psn.0000000000000031

Cited by 62 publications

(32 citation statements)

References 26 publications

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“…26 Therefore layer density may decrease as fluid accumulates since the tissue would appear less tissue dense in the ultrasound image. 27 Use of HFUS in the evaluation of tissue injury then is dependent on accurate measures (dermal and hypodermal layer thickness, dermal and hypodermal layer density) that may reflect changes or injury in the dermis or hypodermis layers.…”

Section: Methodsmentioning

confidence: 99%

Use of high frequency ultrasound to detect changes in skin integrity: An image evaluation validation procedure

Grap

Burk²,

Lucas

et al. 2015

Intensive and Critical Care Nursing

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Objectives High frequency ultrasound scanning may be used for prevention, detection and monitoring of pressure ulcers in patients at risk and is amenable for portable, bedside use by a variety of clinicians. Limited data are available about the criteria to determine an ideal image or measures of tissue changes representative of tissue injury. We developed and evaluated criteria for overall image quality and measures of tissue integrity. Methods In 40 mechanically ventilated adults in 3 ICUs, 241 HFUS sacral images were evaluated for agreement using criteria for overall image quality and tissue changes (dermal, hypodermal layer thickness and layer density). Results HFUS sacral images (N= 241) were evaluated in three analyses and showed poor agreement in all three analyses using the specific criteria for global quality, however when criteria were collapsed agreement was good to substantial. Evaluator agreement for layer thickness and layer density was also good. Conclusions A global rating is adequate for identifying good images. Agreement for measurements of layer thickness and density were also good and may be useful to identify early changes in tissue integrity leading to tissue injury. Additional data are needed concerning the association of changes in layer thickness and layer density to eventual tissue injury.

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Section: Methodsmentioning

confidence: 99%

Use of high frequency ultrasound to detect changes in skin integrity: An image evaluation validation procedure

Grap

Burk²,

Lucas

et al. 2015

Intensive and Critical Care Nursing

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“… 9 The development of devices with frequencies above 15 MHz allowed the differentiation of skin layers, increasing considerably its use in dermatology. 10 The high frequency equipment (>15 Hz) have little penetration and excellent resolution for the study of superficial structures. 11 By analyzing the skin surface in three dimensions, the HFUS, associated with color Doppler, allows the investigation of tumor and inflammatory diseases, the measurement of skin thickness and evaluation of proposed treatments.…”

Section: Introductionmentioning

confidence: 99%

High frequency ultrasound with color Doppler in dermatology

Barcaui

Carvalho

Lopes

et al. 2016

An. Bras. Dermatol.

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Ultrasonography is a method of imaging that classically is used in dermatology to study changes in the hypoderma, as nodules and infectious and inflammatory processes. The introduction of high frequency and resolution equipments enabled the observation of superficial structures, allowing differentiation between skin layers and providing details for the analysis of the skin and its appendages. This paper aims to review the basic principles of high frequency ultrasound and its applications in different areas of dermatology.

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“…Typically, high resolution is seen with high‐frequency ultrasound, however, the absorption and scattering by collateral tissues limits its penetration depth to a few centimeters, largely restricting it to ex vivo applications. [ 42 ] Therefore, continued development of thrombus‐targeting diagnostics, like the NPeps described here, will enable contrast‐enhanced, high‐resolution US imaging at clinically relevant frequencies and imaging depths.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound‐Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis

Sloand

Rokni

Watson

et al. 2021

Adv Healthcare Materials

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Deep vein thrombosis (DVT) is a life‐threatening blood clotting condition that, if undetected, can cause deadly pulmonary embolisms. Critical to its clinical management is the ability to rapidly detect, monitor, and treat thrombosis. However, current diagnostic imaging modalities lack the resolution required to precisely localize vessel occlusions and enable clot monitoring in real time. Here, we rationally design fibrinogen‐mimicking fluoropeptide nanoemulsions, or nanopeptisomes (NPeps), that allow contrast‐enhanced ultrasound imaging of thrombi and synchronous inhibition of clot growth. The theranostic duality of NPeps is imparted via their intrinsic binding to integrins overexpressed on platelets activated during coagulation. The platelet‐bound nanoemulsions can be vaporized and oscillate in an applied acoustic field to enable contrast‐enhanced Doppler ultrasound detection of thrombi. Concurrently, nanoemulsions bound to platelets competitively inhibit secondary platelet–fibrinogen binding to disrupt further clot growth. Continued development of this synchronous theranostic platform may open new opportunities for image‐guided, non‐invasive, interventions for DVT and other vascular diseases.

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Utility of High-Frequency Ultrasound

Cited by 62 publications

References 26 publications

Use of high frequency ultrasound to detect changes in skin integrity: An image evaluation validation procedure

Use of high frequency ultrasound to detect changes in skin integrity: An image evaluation validation procedure

High frequency ultrasound with color Doppler in dermatology

Ultrasound‐Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis

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