Utility of hypertriglyceridemic waist phenotype for predicting incident type 2 diabetes: The Isfahan Diabetes Prevention Study

Janghorbani, Mohsen; Amini, Masoud

doi:10.1111/jdi.12520

Cited by 21 publications

(16 citation statements)

References 32 publications

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“…In a recent cohort study of 2908 Chinese urban adults followed for 3 years, HTGW was associated with a 3·77-fold increased risk of diabetes for males and a 6·08-fold increased risk for females ( 27 ) . Another 4-year longitudinal study of 2900 Korean adults showed increased risk of diabetes with HTGW (hazard ratio=4·113; 95 % CI 2·397, 7·059) after adjustment ( 28 ) , which agrees with our study and a study by Janghorbani and Amini ( 29 ) . Although previous studies did not mention the direct mechanism of the association between HTGW and T2DM, the underlying mechanism of T2DM caused by HTGW might be that excessive abdominal fat accumulation and elevated TAG level increase the risk of insulin resistance ( 30 – 32 ) , and HTGW is associated with overstimulation of β-cell function ( 33 ) , which contributes to blood glucose metabolism disorder and T2DM.…”

Section: Discussionsupporting

confidence: 92%

Prevalence and relationship of hypertriglyceridaemic–waist phenotype and type 2 diabetes mellitus among a rural adult Chinese population

Tian

Liu

Sun

et al. 2019

Public Health Nutr.

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ObjectiveLimited information is available on the prevalence and effect of hypertriglyceridaemic–waist (HTGW) phenotype on the risk of type 2 diabetes mellitus (T2DM) in rural populations.DesignIn the present cross-sectional study, we investigated the prevalence of the HTGW phenotype and T2DM and the strength of their association among rural adults in China.SettingHTGW was defined as TAG >1·7 mmol/l and waist circumference (WC) ≥90 cm for males and ≥80 cm for females. Logistic regression analysis yielded adjusted odds ratios (aOR) relating risk of T2DM with HTGW.ParticipantsAdults (n 12 345) aged 22·83–92·58 years were recruited from July to August of 2013 and July to August of 2014 from a rural area of Henan Province in China.ResultsThe prevalence of HTGW and T2DM was 23·71 % (males: 15·35 %; females: 28·88 %) and 11·79 % (males: 11·15 %; females: 12·18 %), respectively. After adjustment for sex, age, smoking, alcohol drinking, blood pressure, physical activity and diabetic family history, the risk of T2DM (aOR; 95 % CI) was increased with HTGW (v. normal TAG and WC: 3·23; CI 2·53, 4·13; males: 3·37; 2·30, 4·92; females: 3·41; 2·39, 4·85). The risk of T2DM with BMI≥28·0 kg/m2, simple enlarged WC and simple disorders of lipid metabolism showed an increasing tendency (aOR=1·31, 1·75 and 2·32).ConclusionsThe prevalence of HTGW and T2DM has reached an alarming level among rural Chinese people, and HTGW is a significant risk factor for T2DM.

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Section: Discussionsupporting

confidence: 92%

Prevalence and relationship of hypertriglyceridaemic–waist phenotype and type 2 diabetes mellitus among a rural adult Chinese population

Tian

Liu

Sun

et al. 2019

Public Health Nutr.

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“…Furthermore, by crossing positive associations of cluster patterns with cancer risk, abnormal WC+TG had a fundamental predictive influence on this association. Defined as HW phenotype, its involvement in coronary artery disease, insulin resistance, and hypertension has been confirmed (49)(50)(51). As WC cannot fully discriminate visceral adiposity from subcutaneous abdominal adiposity, elevated triglyceride (TG) levels have been adopted as a marker of dysfunctional visceral adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome, and Particularly the Hypertriglyceridemic-Waist Phenotype, Increases Breast Cancer Risk, and Adiponectin Is a Potential Mechanism: A Case–Control Study in Chinese Women

et al. 2020

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Objective: To investigate the association between metabolic syndrome and breast cancer and to elucidate the potential mechanism underlying this association. Patients and Methods: Based on baseline data drawn from 21 hospitals in 11 provinces of China, we performed a case-control study among 1,127 women (595 cases and 532 controls), divided into premenopausal, and postmenopausal subgroups. Student's t test, Pearson's χ 2 test, and logistic regression analyses were performed to ascertain the association between breast cancer and metabolic syndrome, including all of its components. In addition, we attempted to clarify the potential role of adiponectin in this association. Results: Among the components of metabolic syndrome, abnormal waist circumference was the component that markedly increased breast cancer risk in premenopausal women (OR 1.447, 95% CI 1.043-2.006). Metabolic syndrome with clusters of special risk factors showed an association with breast cancer risk. Among Xiang et al. MetS Increases Breast Cancer Risk all these components of metabolic syndrome, the hypertriglyceridemic-waist (HW) phenotype significantly increased breast cancer risk (OR 1.56, 95% CI 1.02-2.39), regardless of menopausal status, rendering it a strong predictor of breast cancer. Total adiponectin levels and high-molecular-weight adiponectin were reversely associated with metabolic syndrome. In addition, total adiponectin levels among breast cancer patients were much lower than among controls (p = 0.005) only in the HW phenotype subgroup. Furthermore, the HW phenotype was associated with increased risk of estrogen receptor/progesterone receptor-positive (ER+/PR+) breast cancer, with a 95% (OR = 1.95, 95% CI:1.21-3.13) increase. However, there was no significant association between the HW phenotype and both ER+/PR-and ER-/PR-subtypes. These results suggested that low adiponectin levels may be a mechanism that explains the association between the HW phenotype and breast cancer risk. Conclusion: Metabolic syndrome with special cluster factors is related to breast cancer risk; in particular, the HW phenotype can be regarded as a strong predictor of breast cancer. As an important factor involved in fat metabolism, adiponectin may strongly predict metabolic syndrome, especially the HW phenotype and breast cancer. Further research into this mechanism and epidemiological studies are needed. This study provides new evidence for the role of a healthy lifestyle in preventing breast cancer.

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“…The Kaplan–Meier survival analysis indicated that high TG levels may predict higher incidences of T2DM. In a previous cross-sectional study, the odds ratio was for T2DM was 1.87 (95% CI 1.29–2.70) [22]; while the odds ratio in prediabetes and T2DM was 1.96 (95% CI 1.42–2.69) and 3.91 (95% CI 2.78–5.51) in a rural Bangladeshi study [23]. Both of these studies showed TG was a risk factor for T2DM although there are significant differences in numerical value.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride is an independent predictor of type 2 diabetes among middle-aged and older adults: a prospective study with 8-year follow-ups in two cohorts

et al. 2019

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BackgroundAlthough there is abundant evidence indicating the connection between triglyceride and type 2 diabetes mellitus (T2DM), few reports or cohort studies confirm that high TG concentration may predict the incidence of T2DM independently. Thus, we studied the association between triglyceride (TG) and T2DM in a male-dominated, middle and older aged cohort, Tianjin General Hospital Cohort. And we further verified our results in the China Health and Retirement Longitudinal Study (CHARLS).MethodsWe conducted an 8-year retrospective cohort study (2009–2017) with 7241 participants who were free from T2DM at baseline. Three groups were constructed based on baseline TG levels (normal, borderline-high, and high). We used a Cox proportional hazards model to evaluate the relationship between TG and T2DM after adjusting for possible risk factors. A Kaplan–Meier survival analysis was performed to compare the incidence of T2DM among subjects in each TG group. We also tested the association between TG and T2DM in the CHARLS cohort.ResultsIn Tianjin General Hospital Cohort, 7241 participants (male 75.8%, female 24.2%) were included, mean age was 61.49 ± 13.85 years at baseline. The cumulative incidence of T2DM in our cohort study was 8.6% (9.2% in men and 6.6% in women). Compared with the normal TG group, the hazard ratios in the borderline and high group were 1.30 (95% CI 1.04–1.62) and 1.54 (95% CI 1.24–1.90). The Kaplan–Meier survival analysis indicated that higher TG levels may predict higher onset of T2DM. These results were verified in the CHARLS cohort, the hazard ratio with T2DM (95% CI) for logTG was 3.94 (2.64–5.87).ConclusionsOur findings suggest that the TG level may be an independent risk factor and predictor for T2DM.

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Utility of hypertriglyceridemic waist phenotype for predicting incident type 2 diabetes: The Isfahan Diabetes Prevention Study

Cited by 21 publications

References 32 publications

Prevalence and relationship of hypertriglyceridaemic–waist phenotype and type 2 diabetes mellitus among a rural adult Chinese population

Prevalence and relationship of hypertriglyceridaemic–waist phenotype and type 2 diabetes mellitus among a rural adult Chinese population

Metabolic Syndrome, and Particularly the Hypertriglyceridemic-Waist Phenotype, Increases Breast Cancer Risk, and Adiponectin Is a Potential Mechanism: A Case–Control Study in Chinese Women

Triglyceride is an independent predictor of type 2 diabetes among middle-aged and older adults: a prospective study with 8-year follow-ups in two cohorts

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