Utility of Bis‐Hydrazonoyl Chlorides as Precursors for Synthesis of New Functionalized Bis‐Thiadiazoles as Potent Antimicrobial Agents

Abstract

in Wiley Online Library (wileyonlinelibrary.com).N 0 ,N″- ([1,-4,4 0 -diyl)bis(2-oxopropanehydrazonoyl chloride) is considered to be the key intermediate for the synthesis of a variety bis-1,3,4-thiadiazole derivatives in one step methodology with good yields by reaction of with a series of hydrazinecarbodithioate derivatives 2a-e, 6a,b, and 8a-e. The assigned structures for all the newly synthesized compounds were confirmed on the basis of elemental analyses and spectral data (infrared, NMR, and mass), and the mechanisms of their formation were also discussed. Moreover, the antimicrobial activity for twelve selected products was screened, and the results obtained exploring the high potency of some of the tested compounds compared with the employed standard bactericides and fungicides. In addition, the minimum inhibitory concentration of the tested compounds was determined, and the results obtained exploring the high potency of three of the tested compounds against all the tested microorganisms.

Microwave-Assisted One Pot Three-Component Synthesis of Novel Bioactive Thiazolyl-Pyridazinediones as Potential Antimicrobial Agents against Antibiotic-Resistant Bacteria

“…Maleic anhydride 1 , thiosemicarbazide 2 , chitosan, aniline and pyridine were purchased from Sigma Aldrich Kingdom of Saudi Arabia and were used without further purification. Hydrazonoyl halides 3a–f, 7a–e and bis -hydrazonoyl halides 12a,b were prepared according to the reported methods [ 50 , 51 ].…”

Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates

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Light-assisted green and efficient construction of thiadiazole/selenadiazole derivatives

“…27–29 In recent years, potassium thiocyanate (KSCN) has emerged as a promising alternative due to its low toxicity and non-irritating nature, making it an ideal sulfur source for the synthesis of 1,3,4-thiadiazole compounds. 30–32 However, current synthetic routes utilizing KSCN often require harsh reaction conditions, 33,34 such as high temperature or pressure, as well as the use of transition metal and acid–base catalysts, which make the further development and application of thiadiazole and selenadiazole derivatives difficult.…”