Utility of interventional-CT (IVR-CT) in transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma: a comparative study of TACE with and without IVR-CT

This study aimed to identify the optimal concentration, injection rate, and total volume of contrast medium (CM) for evaluating the hemodynamics of a hepatocellular carcinoma (HCC) structure model of diameter 35 mm, using multi-level dynamic computed tomography (M-LDCT) with 64 detector rows. A tube was inserted in the model as a simulated vessel. Five CM concentrations were used: non-diluted, 2-, 3-, 6-, and 9-fold diluted. Five regions of interest were placed within the HCC structure model. Time-density curves were created for CM injection rates of 1, 2, and 3 ml/s for 10 s, and for a total volume of 10 ml, followed by saline injection at 1 ml/s. M-LDCT maximum intensity projection images were evaluated by four appraisers using a three-point scale (excellent, 2; good, 1; poor, 0). There was no significant difference between maximum CT values at 2 ml/s for 10 s and those at 3 ml/s; these values were both greater than those at 1 ml/s. The duration of the peak was maintained for longer at 3 ml/s for 10 s (5.2 ± 2.3 s) than at 2 ml/s (3.6 ± 0.9 s). Maximum CT values at 2 ml/s of a total volume of 10 ml were greater than those at 3 ml/s. The highest scores of 7 and 8 were found at 2 and 3 ml/s for 10 s, using 2-, 3-, or 6-fold diluted CM. The most appropriate CM rate for evaluating hemodynamics was 2 ml/s for 10 s, using 2-, 3-, or 6-fold diluted CM.

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Optimal injection rate and volume of contrast medium for observing hemodynamics of a hepatocellular carcinoma structure model

Murotani

Kawai

Sato

et al. 2012

Radiol Phys Technol

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Optimum CT reconstruction parameters for vascular and hepatocellular carcinoma models in a liver phantom with multi-level dynamic computed tomography with 64 detector rows: a basic study

Murotani

Kawai

Sato

et al. 2013

Radiol Phys Technol

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We quantified to clarify the optimum factors for CT image reconstruction of an enhanced hepatocellular carcinoma (HCC) model in a liver phantom obtained by multi-level dynamic computed tomography (M-LDCT) with 64 detector rows. After M-LDCT scanning of a water phantom and an enhanced HCC model, we compared the standard deviation (SD, 1 ± SD), noise power spectrum (NPS) values, contrast-noise ratios (CNR), and the M-LDCT image among the reconstruction parameters, including the convolution kernel (FC11, FC13, and FC15), post-processing quantum filters (2D-Q00, 2D-Q01, and 2D-Q02) and slice thicknesses/slice intervals. The SD and NPS values were lowest with FC11 and 2D-Q02. The CNR values were highest with 2D-Q02. The M-LDCT image quality was highest with FC11 and 2D-Q02, and with slice thicknesses/slice intervals of 0.5 mm/0.5 mm and 0.5 mm/0.25 mm. The optimum factors were the FC11 convolution kernel, 2D-Q02 quantum filter, and 0.5 mm slice thickness/0.5 mm slice interval or less.

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Usefulness of Y-shaped sheaths in CT angiography for examination of liver tumors

Ishikawa

Higuchi²,

Kubota³

et al. 2010

WJG

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Utility of interventional-CT (IVR-CT) in transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma: a comparative study of TACE with and without IVR-CT

Cited by 3 publications

References 2 publications

Optimal injection rate and volume of contrast medium for observing hemodynamics of a hepatocellular carcinoma structure model

Optimal injection rate and volume of contrast medium for observing hemodynamics of a hepatocellular carcinoma structure model

Optimum CT reconstruction parameters for vascular and hepatocellular carcinoma models in a liver phantom with multi-level dynamic computed tomography with 64 detector rows: a basic study

Usefulness of Y-shaped sheaths in CT angiography for examination of liver tumors

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