Utility of Microhemorrhage as a Diagnostic Tool in Distinguishing Vestibular Schwannomas from other Cerebellopontine Angle (CPA) Tumors

Saigal, Gaurav; Pisani, Leonardo; Allakhverdieva, E.; Aristizabal, J.; Lehmkuhl, D.; Contreras, Francisco; Bhatia, Rita; Sidani, Charif; Quencer, Robert M.

doi:10.1007/s12070-021-02372-8

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Histopathological studies have suggested that intratumoral fibrosis might represent indirect evidence of prior microbleeds, so almost all patients in their study showed signs of schwannoma bleeding ( 11 ). The etiology of schwannomas being more prone to hemorrhage than meningiomas remains unclear, but the visualization of intratumoral microbleeds was useful in the differentiation of schwannomas from other CPA masses, particularly meningiomas ( 20 ). Various risk factors have been suggested, including large tumor size, rapid tumor growth, the intratumoral genesis of abnormal thin-walled vasculature, increased tumor vascularity, and mixed Antoni A and B cellularity on histopathology ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Peliminary exploration on the differential diagnosis between meningioma and schwannoma using contrast-enhanced T1WI flow-sensitive black-blood sequence

Cao

et al. 2023

Front. Oncol.

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IntroductionContrast-enhanced T1WI flow-sensitive black-blood (CE-T1WI FSBB) is a newly developed sequence which had not been widely used for differential diagnosis of brain tumors.MethodsTo quantify the pre-operative imaging features of intratumoral microbleeds and intratumoral vessels using CE-T1WI FSBB scan and study the differences in biological behavior of meningiomas and schwannomas underlying the imaging features. Seventy-three cases of meningiomas and 24 cases of schwannomas confirmed by postoperative pathology were included. Two neuroradiologists independently counted intratumoral vessels and intratumoral microbleeds based on CE-T1WI FSBB images. The vessel density index (VDI) and microbleed density index (MDI) were the number of intratumoral vessels and the number of intratumoral microbleeds divided by the tumor volume, respectively. The consistency test of intratumoral vessel count and intratumoral microbleed count based on CE-T1WI FSBB were summarized using 2-way random intraclass correlation coefficients (ICC). Mann–Whitney U-test and chi-square test were used to determine significant differences between meningiomas and schwannomas, and fibrous meningiomas and epithelial meningiomas. P<0.05 was considered statistically significant.ResultsThe ICC of intratumoral vessels count and intratumoral microbleeds count were 0.89 and 0.99, respectively. There were significant differences in the number of intratumoral microbleeds (P<0.01) and MDI values (P<0.01) between meningiomas and schwannomas. There were no differences in the number of intratumoral vessels (P=0.64), VDI (P=0.17), or tumor volume (P=0.33). There were also differences in the number of intratumoral microbleeds (P<0.01), the MDI value (P<0.01), and the sex of patients (P<0.05) between fibrous meningiomas and epithelial meningiomas.DiscussionCE-T1WI FSBB can be a new technique for differentiating schwannomas from meningiomas, and even different types of meningiomas. Schwannomas have a higher incidence of intratumoral hemorrhage, more intratumoral microbleeds, and higher MDI values than meningiomas, which provides a new basis for preoperative differential diagnosis and treatment decisions.

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Section: Discussionmentioning

confidence: 99%

Peliminary exploration on the differential diagnosis between meningioma and schwannoma using contrast-enhanced T1WI flow-sensitive black-blood sequence

Cao

et al. 2023

Front. Oncol.

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Acute Macrocystic Thoracic Schwannoma: Systematic Review and Illustrative Case Example

Fassina,

Oslin,

Shi

et al. 2024

World Neurosurgery

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Comparative Evaluation of the Possibilities of Radiomic Аnalysis of Magnetic Resonance Imaging in the Differential Diagnostics of Primary Extra-Axial Intracranial Tumors

Surovcev

Kapishnikov

Колсанов

2023

Issled. prakt. med. (Print)

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Purpose of the study. Comparing magnetic resonance imaging (MRI) abilities in differential diagnostic of three types of primary extra‑ axial brain tumors (benign and malignant meningiomas, and neuromas) based on standard semiotics and radiomic features.Patients and methods. Retrospective research included 66 patients with primary extra‑a xial tumors who were divided into two groups: the instructional (39 patients) and the valid (27 patients). MRI was used towards all patients before surgery. The one method of statistical modeling – discriminant analysis – was used to compare the abilities of differential diagnostic based on semiotic features and radiomic parameters.Results. The features of tumor semiotics MRI didn’t allow to differentiate effectively benign and malignant meningiomas. Several parameters were certainly varied for all those tumor types (neuromas, benign and malignant meningiomas). The modelling based on the discriminant analysis demonstrated that radiomic features can be used for primary extra‑a xial tumors differential diagnostic. The area of the radiomic model ROC‑curve took 0.86 which exceeds the result of the model based on semiotic features (AUC 0.78).Conclusion. The best results of the tumors classification by radiomic model demonstrate expediency to continue research the primary extra‑ axial tumors differential diagnostic with support of histogram and textural parameters of MRI imaging.

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Utility of Microhemorrhage as a Diagnostic Tool in Distinguishing Vestibular Schwannomas from other Cerebellopontine Angle (CPA) Tumors

Cited by 4 publications

References 13 publications

Peliminary exploration on the differential diagnosis between meningioma and schwannoma using contrast-enhanced T1WI flow-sensitive black-blood sequence

Peliminary exploration on the differential diagnosis between meningioma and schwannoma using contrast-enhanced T1WI flow-sensitive black-blood sequence

Acute Macrocystic Thoracic Schwannoma: Systematic Review and Illustrative Case Example

Comparative Evaluation of the Possibilities of Radiomic Аnalysis of Magnetic Resonance Imaging in the Differential Diagnostics of Primary Extra-Axial Intracranial Tumors

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