Utility of Nanomedicine for Cancer Treatment

Louis, H; Oyebanji, Oyetola O.; Bi, Ita; Pi, Amos; Philip, Mary

doi:10.4172/2157-7439.1000481

Cited by 4 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, chemotherapy and radiation therapy have many side effects such as damage to healthy tissue, hair loss, nausea, and bowel issues. To overcome these limitations, nanomaterials were extensively studied as a targeted drug delivery method for cancer therapy (Hussain, 2018). One of these materials is Ti 3 C 2 also known as MXene, which is a 2D material where M stands for an early transition metal, X is carbon or nitrogen, and -ene is just like in graphene which is the first 2D material discovered.…”

Section: Introductionmentioning

confidence: 99%

Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions

Shurbaji

Manaph

Ltaief

et al. 2021

Front. Nanotechnol.

View full text Add to dashboard Cite

A growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer photothermal therapy. To be most effective, photothermal agents need to be internalized by the cancer cells. In this study, MXene was fabricated using chemical reactions and tested as a photothermal agent on MDA-231 breast cancer cells under static and physiological conditions. Fluid shear stress (∼0.1 Dyn/cm2) was applied using a perfusion system to mimic the physiological tumor microenvironment. The uptake of MXene was analyzed under fluid flow compared to static culture using confocal microscopy, scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), and transmission electron microscopy (TEM). Furthermore, a viability assay was used to assess cell’s survival after exposing the treated cells to photothermal laser at different power densities and durations. We showed that when incubated with cancer cells, 2D MXene nanoparticles were successfully internalized into the cells resulting in increased intracellular temperatures when exposed to NIR laser. Interestingly, dynamic culture alone did not result in a significant increase in uptake suggesting the need for surface modifications for enhanced cellular uptake under shear stress.

show abstract

Section: Introductionmentioning

confidence: 99%