Abstract-A composite measure of subclinical vascular disease has been developed in the Cardiovascular Health Study (CHS). In previous reports, we measured the prevalence of subclinical disease among the original 5201 participants in the CHS, the relationship of risk factors to subclinical disease, and the association of subclinical disease to clinical coronary heart disease. In 1992 to 1993 (year 4 of the study), a larger cohort of 424 black women and 248 black men was added to the study. In this study, we have compared the prevalence of subclinical disease among blacks and whites in the CHS and the association with cardiovascular risk factors. The prevalence of subclinical disease for all participants (aged Ն65 years) was 41.3% for white women, 39.7% for black women, 41.9% for white men, and 43.7% for black men. The prevalence increased with age. The risk factor associations for subclinical disease were similar among blacks and whites. In multivariate analysis, age, systolic blood pressure, LDL cholesterol, smoking, and family history of myocardial infarction were independently associated with subclinical disease among both black and white women, while for white men, systolic blood pressure, use of antihypertensive medication, smoking, body mass index, and diastolic blood pressure (inverse) were related to subclinical disease. In black men, blood triglyceride level, use of antihypertensive medications, and family history of myocardial infarction (inverse) were associated with subclinical disease. A n important issue in cardiovascular disease research is whether the relationship between risk factors and cardiovascular disease is similar among different races, sexes, and ethnic groups. Most epidemiological studies have focused primarily on white populations. We have previously reported the relationship between risk factors and subclinical disease among whites in the Cardiovascular Health Study (CHS) 1 and the association of subclinical disease among whites and risk of clinical disease over an approximate 2.4-year follow-up. 2 We have also documented the prevalence of individual components (ie, specific measurements) of subclinical disease and the relationship of these attributes to risk factors, among a smaller sample of blacks measured at baseline in the year from 1989 to 1990 of the CHS. 3 The purpose of this study is to determine the risk factors for a composite measure of subclinical disease 1 among a larger sample of black and white participants in the CHS to determine whether there are any differences in key risk factors between blacks and whites.There were 153 black women (5.2%) and 91 black men (4.1%) aged Ն65 years among the original 5201 CHS participants recruited in 1989 to 1990 (year 1 of the CHS). In 1992 to 1993 (year 4 of the study), a larger cohort, consisting of 424 black women and 248 black men, was added to the CHS. The recruitment methods, using the Medicare participant files as a sampling frame, were the same as those for the baseline population in 1989 to 1990. 3 This study includes the ...