Utility of Noninvasive Endothelial Function Test for Prediction of Deep Vein Thrombosis After Total Hip or Knee Arthroplasty

Suzuki, Hiroyuki; Matsuzawa, Yasushi; Konishi, Masaaki; Akiyama, Eiichi; Takano, Kazuo; Nakayama, Naoki; Kataoka, Satoshi; Ebina, Toshiaki; Kosuge, Masami; Hibi, Kiyoshi; Tsukahara, Kengo; Iwahashi, Noriaki; Endo, Mitsuaki; Maejima, Nobuhiko; Shinohara, K.; Taki, Naoya; Mitsugi, Naoto; Taguri, Masataka; Sugiyama, Seigo; Ogawa, Hisao; Umemura, Satoshi; Kimura, Kazuo

doi:10.1253/circj.cj-13-1325

Cited by 27 publications

(20 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…EndoPAT 2000 device (Itamar Medical Ltd., Caesarea, Israel) was used to evaluate peripheral arterial endothelial function, as described previously [10,14,18,19,20,21]. Pneumatic probes were applied to the tip of one finger on each hand to measure digital volume changes accompanying arteriolar tone changes.…”

Section: Methodsmentioning

confidence: 99%

Utility of both carotid intima–media thickness and endothelial function for cardiovascular risk stratification in patients with angina-like symptoms

Matsuzawa

Svedlund

Aoki

et al. 2015

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Background Myocardial perfusion scintigraphy (MPS) is used widely to assess cardiovascular risk in patients with chest pain. The utility of carotid intima-media thickness (CIMT) and endothelial function as assessed by reactive hyperemia-peripheral arterial tonometry index (RHI) in risk stratifying patients with angina-like symptom needs to be defined. We investigated whether addition of CIMT and RHI to Framingham Cardiovascular Risk Score (FCVRS) and MPS improves comprehensive cardiovascular risk prediction in patients presenting with angina-like symptom. Methods We enrolled 343 consecutive patients with angina-like symptom suspected of having stable angina. MPS, CIMT, and RHI were performed and patients were followed for cardiovascular events for a median of 5.3 years (range 4.4-6.2). Patients were stratified by FCVRS and MPS. Results During the follow-up, 57 patients (16.6%) had cardiovascular events. Among patients without perfusion defect, low RHI was significantly associated with cardiovascular events in the intermediate and high FCVRS groups (Hazard ratio (HR) [95% confidence interval (CI)] of RHI≤2.11 was 6.99 [1.34-128] in the intermediate FCVRS group and 6.08 [1.08-114] in the high FCVRS group). Furthermore, although MPS did not predict, only RHI predicted hard cardiovascular events (cardiovascular death, myocardial infarction, and stroke) independent from FCVRS, and adding RHI to FCVRS improved net reclassification index (20.9%, 95% CI 0.8-41.1, p=0.04). Especially, RHI was significantly associated with hard cardiovascular events in the high FCVRS group (HR [95% CI] of RHI≤1.93 was 5.66 [1.54-36.4], p=0.007). Conclusions Peripheral endothelial function may improve discrimination in identifying at-risk patients for future cardiovascular events when added to FCVRS-MPS-based risk stratification.

show abstract

Section: Methodsmentioning

confidence: 99%

Utility of both carotid intima–media thickness and endothelial function for cardiovascular risk stratification in patients with angina-like symptoms

Matsuzawa

Svedlund

Aoki

et al. 2015

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…20, 22 In addition, Suzuki et al reported that impairment of endothelial function assessed by RH-PAT was related to systemic thrombosis in patients after lower limb arthroplasty. 9 That study also demonstrated an overlap of many risk factors, which are included in clinical risk stratification using the CHA2DS2-VASc score as recommended by the European Society of Cardiology, 23 and these factors were associated with the development of spontaneous deep vein thrombosis. Our study results suggested that a noninvasive test of peripheral endothelial function using RH-PAT could assess the possible thromboembolic source or severity of atherosclerosis, and might explain the improvement in clinical risk stratification in patients with AF.…”

Section: Endothelial Function As Clinical Risk Stratificationmentioning

confidence: 79%

Clinical Significance of Peripheral Endothelial Function for Left Atrial Blood Stagnation in Nonvalvular Atrial Fibrillation Patients With Low-to-Intermediate Stroke Risk

Fujii

Inoue

Nagai

et al. 2016

Circ J

View full text Add to dashboard Cite

“…9, 10 Preoperative endothelial dysfunction has previously been demonstrated to be a predictor of postoperative adverse events (AEs) in patients with peripheral vascular surgery, 11 general thoracic surgery, 12 and total hip or knee arthroplasty. 13 However, there are no data about this issue in patients undergoing cardiovascular surgery. Furthermore, endothelial dysfunction is also associated with the pathogenesis of atrial fibril-Endothelial Function and Cardiovascular Surgery EndoPAT2000 device.…”

Section: Study Populationmentioning

confidence: 99%

“…The principle of RH-PAT measurement has been previously described. 13,18,19 In brief, the patients fasted and refrained from caffeine, tobacco or medications for at least 8 h. The test was conducted in a quiet and temperaturecontrolled room in the early morning. A finger probe was placed on each index finger, and the air cuff was connected by a pneumatic tube to the inflation device.…”

Section: Rh-patmentioning

confidence: 99%

“…9,10 Preoperative assessment of endothelial function is reportedly useful to predict postoperative events in patients undergoing various types of surgery. 11- 13 Schier et al demonstrated that patients with low FMD had more postoperative events that consisted of cardiac events, pulmonary events (e.g., prolonged ventilation), wound infection, or reoperative intervention among subjects undergoing general thoracic surgery, including esophagectomy and major lung surgery. 12 Cardiovascular surgery is one of the most challenging among the various surgical fields, and the postoperative event rate is substantially high.…”

Section: Disclosuresmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative Assessment of Endothelial Function for Prediction of Adverse Events After Cardiovascular Surgery

Saito

Kitahara

Matsumiya

et al. 2018

Circ J

View full text Add to dashboard Cite

Background: Cardiovascular surgery is one of the highest risk procedures in the field of surgery. Preoperative assessment of endothelial function has been reported as useful for predicting postoperative adverse events (AEs). The aim of this study was to investigate the relationship between endothelial function assessed by reactive hyperemia index (RHI) and AEs after cardiovascular surgery. Methods and Results:A prospective observational study of 197 patients who underwent cardiovascular surgery was conducted. RHI was measured before the surgery. The primary endpoint was a composite of postoperative death, reoperation, stroke, newly required dialysis, deep sternum infection, and prolonged ventilation within 30 days. The secondary endpoint was new-onset atrial fibrillation (AF) within 30 days. Following cardiovascular surgery, 19 patients (9.6%) had AEs. New-onset AF was documented in 42 (25.9%) of 162 patients without a prior history of AF. In the receiver-operating characteristic curve analysis, RHI significantly predicted AEs (area under the curve [AUC] 0.67, best cutoff value 1.64, P=0.03), whereas RHI did not predict new-onset AF (AUC 0.53, P=0.93). Patients with RHI ≤1.64 had more AEs than those with RHI >1. 64 (16.3% vs. 4.5%, P=0.005). Multiple logistic regression analysis showed the number of surgical procedures and RHI ≤1.64 as significant predictors of AEs. Conclusions:Preoperative endothelial dysfunction assessed by RHI was associated with postoperative AEs in patients with cardiovascular surgery.

show abstract

Utility of Noninvasive Endothelial Function Test for Prediction of Deep Vein Thrombosis After Total Hip or Knee Arthroplasty

Cited by 27 publications

References 51 publications

Utility of both carotid intima–media thickness and endothelial function for cardiovascular risk stratification in patients with angina-like symptoms

Utility of both carotid intima–media thickness and endothelial function for cardiovascular risk stratification in patients with angina-like symptoms

Clinical Significance of Peripheral Endothelial Function for Left Atrial Blood Stagnation in Nonvalvular Atrial Fibrillation Patients With Low-to-Intermediate Stroke Risk

Preoperative Assessment of Endothelial Function for Prediction of Adverse Events After Cardiovascular Surgery

Contact Info

Product

Resources

About