Utility of Optical Coherence Tomography for Guiding Laser Therapy Among Patients With Recurrent Respiratory Papillomatosis

Benboujja, Fouzi; Bowe, Sarah N.; Boudoux, Caroline; Hartnick, Christopher J.

doi:10.1001/jamaoto.2018.1375

Cited by 7 publications

(17 citation statements)

References 35 publications

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“…In this case, we did not automatically detect the coagulation as proposed in Eq. (14). The reason for this was the small ensemble size used, (z = 3, x = 10, t = 10) pixels.…”

Section: Discussionmentioning

confidence: 99%

“…To mitigate this, we limited the correction of motion-induced decorrelation to g (2) >1.3; for g (2) ≤ 1.3 we consider any measure of g (2) to be inaccurate and the checking of the coagulation conditions of Eq. (14) are not performed. This allows the mode to continue working despite sudden and large motion.…”

Section: Discussionmentioning

confidence: 99%

“…The collimated beam had a diameter of 2 mm before being reflected by the galvanometer (galvo) silver-coated mirror (Thorlabs GVS001) and going through the 20 mm focal length uncoated imaging lens resulting in a theoretical beam waist of 20.8 µm and a working distance of 1.06 mm in air. The therapy laser wavelength was selected because it corresponds with a peak in the absorption spectrum of hemoglobin and because it has been validated extensively in clinical applications [6,14]. Note that there is no limitation on the wavelength used for the therapy except for the DCFC, which supports wavelengths up to 1750 nm.…”

Section: Methodsmentioning

confidence: 99%

“…The correlation is calculated at this targeted depth in real time to perform the coagulation-threshold values checks, outlined Eq. (14).…”

Section: Monitoring In Real-timementioning

confidence: 99%

“…Laser therapy allows for targeted removal or thermal coagulation of tissues through light absorption by various absorbers in the tissue, such as water, hemoglobin and other macromolecules [1][2][3]. It is used in the treatment of epithelial cancerous and pre-cancerous lesions such as Barrett's esophagus [4][5][6], in eye diseases such as diabetic retinopathy [7][8][9][10] and retinal vein occlusion [11,12] and in respiratory papillomatosis, a viral-induced disease in the upper airway [13,14]. However, accurate monitoring is essential to avoid over-or under-treatment.…”

Section: Introductionmentioning

confidence: 99%

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Real-time co-localized OCT surveillance of laser therapy using motion corrected speckle decorrelation

Maltais-Tariant¹,

Boudoux²,

Uribe-Patarroyo³

2020

Biomed. Opt. Express

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We present a system capable of real-time delivery and monitoring of laser therapy by imaging with optical coherence tomography (OCT) through a double-clad fiber (DCF). A double-clad fiber coupler is used to inject and collect OCT light into the core of a DCF and inject the therapy light into its larger inner cladding, allowing for both imaging and therapy to be perfectly coregistered. Monitoring of treatment depth is achieved by calculating the speckle intensity decorrelation occurring during tissue coagulation. Furthermore, an analytical noise correction was used on the correlation to extend the maximum monitoring depth. We also present a method for correcting motion-induced decorrelation using a lookup table. Using the value of the noise-and motion-corrected correlation coefficient in a novel approach, our system is capable of identifying the depth of thermal coagulation in real time and automatically shut the therapy laser off when the targeted depth is reached. The process is demonstrated ex vivo in rat tongue and abdominal muscles for depths ranging from 500 µm to 1000 µm with induced motion in real time.

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“…In this case, we did not automatically detect the coagulation as proposed in Eq. (14). The reason for this was the small ensemble size used, (z = 3, x = 10, t = 10) pixels.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The correlation is calculated at this targeted depth in real time to perform the coagulation-threshold values checks, outlined Eq. (14).…”

Section: Monitoring In Real-timementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Real-time co-localized OCT surveillance of laser therapy using motion corrected speckle decorrelation

Maltais-Tariant¹,

Boudoux²,

Uribe-Patarroyo³

2020

Biomed. Opt. Express

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Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

et al. 2021

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Objectives/Hypothesis Identifying distinctive features of the vocal fold (VF) during development could have significant clinical implications for treating voice disorders. This study investigates the structural organization of the VF microanatomy across gender and age groups using optical coherence tomography (OCT). Study Design Prospective clinical trial. Materials and Methods In vivo OCT images were acquired from 97 patients (58 males and 39 females) aged between 6 weeks and 27 years. All patients showed no signs of vocal fold pathology on endoscopy. Morphological features were extracted from OCT images and statistically compared between age groups. This study was performed at Massachusetts Eye and Ear between 2017 and 2019. Results All OCT acquisitions show a stratified microanatomy across age groups, even in newborns suggesting the presence of a superficial lamina propria (SLP) at birth. Furthermore, the optical scattering in the VF lamina propria changes according to age, suggesting subepithelial maturation. Although the epithelium thickness was relatively constant across age groups, the SLP showed a significant linear relationship between age and thickness (P = .016). Furthermore, a significant difference (P = .002) in SLP thickness was found between young adult males and females. The overall thickness of the entire mucosa did not change significantly with age. Conclusion OCT is a noninvasive imaging modality capable of providing quantitative morphological features to describe the VF development. A stratified structure can be observed in OCT from newborns to young adults. Further investigations could combine OCT, acoustic measurements, and molecular sensitive techniques to provide a complete interpretation of the VF development. Level of Evidence NA Laryngoscope, 131:E2558–E2565, 2021

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Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

Benboujja

Hartnick

2021

Sci Rep

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Identifying distinct normal extracellular matrix (ECM) features from pathology is of the upmost clinical importance for laryngeal diagnostics and therapy. Despite remarkable histological contributions, our understanding of the vocal fold (VF) physiology remains murky. The emerging field of non-invasive 3D optical imaging may be well-suited to unravel the complexity of the VF microanatomy. This study focused on characterizing the entire VF ECM in length and depth with optical imaging. A quantitative morphometric evaluation of the human vocal fold lamina propria using two-photon excitation fluorescence (TPEF), second harmonic generation (SHG), and optical coherence tomography (OCT) was investigated. Fibrillar morphological features, such as fiber diameter, orientation, anisotropy, waviness and second-order statistics features were evaluated and compared according to their spatial distribution. The evidence acquired in this study suggests that the VF ECM is not a strict discrete three-layer structure as traditionally described but instead a continuous assembly of different fibrillar arrangement anchored by predominant collagen transitions zones. We demonstrated that the ECM composition is distinct and markedly thinned in the anterior one-third of itself, which may play a role in the development of some laryngeal diseases. We further examined and extracted the relationship between OCT and multiphoton imaging, promoting correspondences that could lead to accurate 3D mapping of the VF architecture in real-time during phonosurgeries. As miniaturization of optical probes is consistently improving, a clinical translation of OCT imaging and multiphoton imaging, with valuable qualitative and quantitative features, may have significant implications for treating voice disorders.

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Utility of Optical Coherence Tomography for Guiding Laser Therapy Among Patients With Recurrent Respiratory Papillomatosis

Abstract: Concurrent use of OCT imaging and laser therapy may improve postoperative outcomes for patients with RRP by delivering an optimal, patient-tailored treatment. Additional studies investigating the correlation between optical properties with vocal outcomes are required.

Cited by 7 publications

References 35 publications

Real-time co-localized OCT surveillance of laser therapy using motion corrected speckle decorrelation

Real-time co-localized OCT surveillance of laser therapy using motion corrected speckle decorrelation

Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

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