Utility of PET/CT in the diagnosis of inflammatory rheumatic diseases: a systematic review and meta-analysis

Descamps, Lucie; Olagne, L.; Merlin, C.; Cachin, F.; Soubrier, Martin; Mathieu, Sylvain

doi:10.1136/annrheumdis-2017-212660

Cited by 13 publications

(9 citation statements)

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“…Furthermore, interspinous 18 F-FDG uptake, demonstrating interspinous bursitis, is common in PMR (pooled prevalence: 67%). However, these findings are not very specific for PMR [39].…”

Section: Resultsmentioning

confidence: 99%

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Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Treglia

2019

Contrast Media & Molecular Imaging

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Purpose. To date, several meta-analyses have reported data about the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases. This article aims to summarize the published evidence-based data about the diagnostic performance of 18F-FDG PET/CT in this setting. Methods. A comprehensive computer literature search of meta-analyses published in PubMed/MEDLINE and Cochrane library database from January 2009 through December 2018 and regarding the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases was carried out. This combination of key words was used: (i) “PET” OR “positron emission tomography” OR “FDG” OR “fluorodeoxyglucose” AND (ii) meta-analysis. Only records on inflammatory or infectious diseases were selected. Results. The diagnostic performance of 18F-FDG PET/CT in detecting inflammatory and infectious diseases has been summarized taking into account 36 meta-analyses published in the literature. Evidence-based data demonstrated good diagnostic performance of 18F-FDG PET/CT for several inflammatory and infectious diseases, in particular cardiovascular infectious and inflammatory diseases and some musculoskeletal infections. Conclusions. Evidence-based data about the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases are increasing, with good diagnostic performance of this imaging method for some indications. More prospective multicenter studies and cost-effective analyses are warranted.

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“…Furthermore, interspinous 18 F-FDG uptake, demonstrating interspinous bursitis, is common in PMR (pooled prevalence: 67%). However, these findings are not very specific for PMR [39].…”

Section: Resultsmentioning

confidence: 99%

“…Articular 18 F-FDG uptake is not specific for PMR or RA as it is common in other connective tissue diseases (pooled prevalence: 70%). Overall, 18 F-FDG PET/CT is helpful in diagnostic research, but the interpretation of 18 F-FDG uptake at each site is not characteristic of a specific inflammatory rheumatic disease [39].…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Treglia

2019

Contrast Media & Molecular Imaging

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“…130,131 As highlighted by a recent meta-analysis, it can be summarized that PET/CT is of high value, particularly in clinical research. 132 Moreover, rather than the evaluation of high metabolic uptake in single areas, the overall assessment of PET/CT findings may contribute to reach the correct diagnosis.…”

Section: Hybrid Imaging Positron Emission Tomography/computed Tomographymentioning

confidence: 99%

Quantitative Imaging in Inflammatory Arthritis: Between Tradition and Innovation

Giraudo

Kainberger

Boesen

et al. 2020

Semin Musculoskelet Radiol

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Radiologic imaging is crucial for diagnosing and monitoring rheumatic inflammatory diseases. Particularly the emerging approach of precision medicine has increased the interest in quantitative imaging. Extensive research has shown that ultrasound allows a quantification of direct signs such as bone erosions and synovial thickness. Dual-energy X-ray absorptiometry and high-resolution peripheral quantitative computed tomography (CT) contribute to the quantitative assessment of secondary signs such as osteoporosis or lean mass loss. Magnetic resonance imaging (MRI), using different techniques and sequences, permits in-depth evaluations. For instance, the perfusion of the inflamed synovium can be quantified by dynamic contrast-enhanced imaging or diffusion-weighted imaging, and cartilage injury can be assessed by mapping (T1ρ, T2). Furthermore, the increased metabolic activity characterizing the inflammatory response can be reliably assessed by hybrid imaging (positron emission tomography [PET]/CT, PET/MRI). Finally, advances in intelligent systems are pushing forward quantitative imaging. Complex mathematical algorithms of lesions' segmentation and advanced pattern recognition are showing promising results.

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“…Speziell die Sonografie hat nach der Etablierung der neuen Klassifikationskriterien 2012 einen hohen Stellenwert bekommen. Zuletzt lag der Fokus in Studien vermehrt auf der 18 F-FDG-PET-Untersuchung, da diese die Darstellung inflammatorischer Prozesse im gesamten Körper ermöglicht und überdies gleichzeitig den Ausschluss der Differenzialdiagnose einer malignen Grunderkrankung gewährleistet (52). Die fokale FDG-Aufnahme ist bei PMR-Patienten in Übereinstimmung mit den klinischen und sonografischen Befunden in einem typischen Muster gesteigert, welches periartikuläre Bereiche, insbesondere Enthesen und Bursen, an Schulter-und Beckengürtel betrifft.…”

Section: Diagnostikunclassified

Muskelschmerz

Lütgendorf¹,

Triantafyllias²

2018

Arthritis und Rheuma

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ZusammenfassungMyalgien zählen zu den häufigsten Gründen für eine Vorstellung beim Rheumatologen oder Orthopäden. Die Ursachen einer Myalgie sind vielfältig und können ein Trauma, übermäßige körperliche Anstrengung und virale Infekte ebenso umfassen wie eine Genese auf der Basis ernsthafter, nicht entzündlicher Myopathien oder Myositiden. In dieser Übersichtsarbeit richten wir einen Fokus sowohl auf die Diagnostik von häufig auftretenden und damit auch fachübergreifend gut bekannten Krankheitsbildern als auch auf solche, die seltener im rheumatologischen Alltag vorkommen. Vom recht geläufigen chronischen Schmerzsyndrom Fibromyalgie bis hin zum seltenen Krankheitsbild des Antisynthetase-Syndroms werden hier neben den klinischen Bildern neue Daten zu laborchemischen, histologischen und radiologischen Auffälligkeiten der wichtigsten rheumatologischen Erkrankungen diskutiert, welche charakteristisch mit Myalgien einhergehen. Im Rahmen dieser Arbeit wird eines deutlich: Die Komplexität dieser Krankheitsbilder und der Umfang aktueller Forschungsergebnisse fordern die kontinuierliche Schulung der behandelnden Ärzte und eine enge interdisziplinäre Zusammenarbeit der unterschiedlichen Fachdisziplinen.

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Utility of PET/CT in the diagnosis of inflammatory rheumatic diseases: a systematic review and meta-analysis

Abstract: International audienc

Cited by 13 publications

References 5 publications

Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Quantitative Imaging in Inflammatory Arthritis: Between Tradition and Innovation

Muskelschmerz

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Utility of PET/CT in the diagnosis of inflammatory rheumatic diseases: a systematic review and meta-analysis

Abstract: International audienc

Cited by 13 publications

References 5 publications

Diagnostic Performance of 18F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Diagnostic Performance of 18F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Quantitative Imaging in Inflammatory Arthritis: Between Tradition and Innovation

Muskelschmerz

Contact Info

Product

Resources

About

Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses