Utility of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to distinguish malignant from benign ovarian masses

Bakacak, Murat; Serin, Salih; Ercan, Önder; Köstü, Bülent; Bostancı, Mehmet Sühha; Bakacak, Zeyneb; Kıran, Hakan; Grover, Kiran

doi:10.5152/jtgga.2015.0152

Cited by 29 publications

(42 citation statements)

References 23 publications

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“…The NOS scores, which indicated the quality of these studies, ranged from 6 to 8. Five of the selected eligible studies presented data regarding the association between the PLR and OS [14][15][16][17][18] , five studies discussed the link between PLR and PFS [15][16][17][18][19] , and six examined numerical differences in PLR between patients with malignant ovarian masses and the controls [20][21][22][23][24][25] . The disease characteristics in 12 studies are summarized in Table 2.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis

Sun

et al. 2017

Climacteric

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Objectives: The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a metaanalysis to estimate the prognostic value of the PLR in ovarian cancer. Methods: We searched the EMBASE, Medline, PubMed, and Web of Science databases to identify clinical studies that had evaluated the association between the PLR and ovarian cancer prognosis. Outcomes evaluated included overall survival (OS) and progression-free survival (PFS). We also analyzed PLR differences between malignant ovarian masses and the controls. Results: Twelve relevant studies that comprised 2340 patients were selected for the meta-analysis. The results revealed that elevated PLR was significantly associated with poor OS (hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.05-2.56, p < 0.01) and PFS (HR 1.61, 95% CI 1.03-2.51, p < 0.01). The PLRs in malignant cases were higher than in controls (mean difference ¼ 63.57, 95% CI 39.47-87.66, p < 0.00001). Conclusion: An elevated PLR is associated with poor prognosis in patients with ovarian cancer. The PLR could be employed as a prognostic marker in patients with ovarian cancer. ARTICLE HISTORY

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Six studies comprising 1054 patients reported the PLR in patients with malignant ovarian masses and the controls [20][21][22][23][24][25] .…”

Section: Numerical Differences In Plr Between Patients With Malignantmentioning

confidence: 99%

The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis

Sun

et al. 2017

Climacteric

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“…Recently, several studies evaluated the prognostic significance of NLR in patients with ovarian cancer [12-25]. But the results of each individual studies were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Huang

Zhou

Zeng

et al. 2017

Cell Physiol Biochem

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Background and Aims: Published data on the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer are controversial. We conducted this meta-analysis to obtain a more accurate assessment of prognostic significance of NLR in ovarian cancer. Materials and Methods: We conducted a systematic literature search using the electronic databases PubMed, Web of Science, and Embase up to May 2016. Hazard ratio (HR) and odd ratio (OR) with 95% confidence interval (95% CI) were calculated. Subgroup analyses were carried out to explore the source of heterogeneity. Statistical analysis was performed using Stata 10.0. Results: A total of 12 studies, consisting of 3,854 patients, which met our criterion were selected in this meta-analysis. Our pooled results showed that high pre-treatment NLR level was significantly associated with poorer overall survival (OS) (HR: 1.69, 95% CI 1.29-2.22) and shorter progression free survival (PFS) (HR 1.63, 95% CI 1.27–2.09). Additionally, increased NLR was also significantly correlated with advanced FIGO stage (OR 2.32, 95% CI1.79-3.00), higher serum level of CA-125 (OR 3.33, 95% CI 2.43-4.58), more extensive ascites (OR 3.54, 95% CI 2.31-5.42) as well as less chemotheraputic response (OR 0.53, 95% CI 0.40-0.70). The findings from most of subgroup meta-analyses were consistent with those from the overall meta-analyses. Conclusions: Elevated pre-treatment NLR could served as a predicative factor of poor prognosis for ovarian cancer patients.

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“…Plateletcrit (PCT) is a parameter indicating the percentage of platelets in the blood.PCT is dependent to mean platelet volume and platelet count 20 . The number of platelets and ratio of platelet/lymphocyte (PLR) is correlated with cancer diagnosis and severity of the disease 16,19,21 . PLR was also found to be higher in ovarian mass 13,19 .…”

Section: Discussionmentioning

confidence: 99%

“…The number of platelets and ratio of platelet/lymphocyte (PLR) is correlated with cancer diagnosis and severity of the disease 16,19,21 . PLR was also found to be higher in ovarian mass 13,19 . It was mentioned that increased PCT values were due to reactive thrombocytosis in the inflammation 22 .…”

Section: Discussionmentioning

confidence: 99%

Preoperative diagnostic value of hematologic inflammatory markers in ovarian torsion

Bacanakgıl¹,

Kaban²,

Hasanova³

et al. 2019

OBGYN

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Background: Ovarian torsion is a rare gynecologic emergency which diagnosis may be overlooked. Clinic is nonspecific, and there are no reliable laboratory methods to confirm the preoperative diagnosis. Usually, the diagnosis is confirmed during surgery. Objective: The aim of the study is to investigate the availability of diagnostic value neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and plateletcrit (PCT) values of ovarian torsion cases. Methodology: The preoperative hematologic values of 36 ovarian torsion cases which were operated and histopathologically confirmed were compared with 135 control cases. Results: NLR value of the study group was significantly higher than the control group (p=0.001). There were no significant difference in PLR and PCT values (p>0.05). Cut-off value of the NLR was found to be 3.10. This value corresponds to 83.33% sensitivity, 84.44% specificity, 58.80% positive predictive value (PPV) and 95% negative predictive value (NPV). Conclusion: Three and above value of NLR can be used as a hematological marker for the diagnosis of ovarian torsion.

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Utility of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to distinguish malignant from benign ovarian masses

Cited by 29 publications

References 23 publications

The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis

The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Preoperative diagnostic value of hematologic inflammatory markers in ovarian torsion

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