Utility of regional epithelial thickness measurements in corneal evaluations

Hwang, Eric S.; Schallhorn, Julie M.; Randleman, J. Bradley

doi:10.1016/j.survophthal.2019.09.003

Cited by 55 publications

(47 citation statements)

References 77 publications

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“…We support the practice of careful screening of the candidate cases by epithelial mapping and Placido-disc topography-both means of establishing anterior corneal surface regularity-as an important screening step. [23][24][25][26][27][28][29] Further studies may further validate the data presented in this preliminary feasibility study.…”

Section: Discussionsupporting

confidence: 58%

<p>Initial Outcomes with Customized Myopic LASIK, Guided by Automated Ray Tracing Optimization: A Novel Technique</p>

Kanellopoulos

2020

OPTH

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Section: Discussionsupporting

confidence: 58%

<p>Initial Outcomes with Customized Myopic LASIK, Guided by Automated Ray Tracing Optimization: A Novel Technique</p>

Kanellopoulos

2020

OPTH

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“…The epithelium has a significant remodeling ability that responds to changes in the underlying interstitial pathology or pre-corneal curvature. Advances in human corneal epithelial measurement techniques have led to substantial developments in the characterization of the pathological behavior of the cornea (such as keratoconus), screening for refractive surgery candidates, and understanding the normal, pathological and postoperative epithelial remodeling processes [32]. In the present study, no significant difference was found in the central corneal thickness following treatment with 0.5% PH.…”

Section: Discussioncontrasting

confidence: 51%

Effect of Proparacaine Hydrochloride Eye Drops on the Ocular Surface

Li¹,

Wang²,

Wang³

et al. 2021

IJOVS

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Background: Proparacaine hydrochloride (PH), as a a local anesthetic, is used regularly in ophthalmic surgery and optometry. However, few pieces of research on the ocular surface toxicity of PH eye drops have so far been reported. Purpuse: To evaluate the effect of PH on the ocular surface of mice. Methods: Male C57/BL6 mice were divided into four groups: normal, vehicle-treated, 0.05% PH-treated and 0.5% PH treated 7 days. The clinical indications were tear production, corneal sensitivity, and fluorescein staining. The structure and morphology of the cornea were examined by confocal microscopy; the thickness of the corneal center was examined by anterior segment optical coherence tomography (AS-OCT); and the corneal epithelial microvilli morphology was examined using scanning electron microscopy. Hematoxylin-eosin staining was used to characterize the central corneal morphology. Immunofluorescence staining for cytokeratin 10 (K10) was employed to evaluate squamous metaplasia in the corneal epithelium. Results: The results show that topical PH treatment diminished tear production and corneal sensitivity, and increased corneal fluorescein staining scores. Moreover, PH altered the corneal epithelial microvilli morphology, disrupted the epithelial barrier of the cornea, and promoted apoptosis of ocular surface cells. Furthermore, the expression of K10 in the corneal epithelium was found to be increased. Conclusion: Treatment with 0.5% PH caused instability of the tear film, and changes in corneal sensitivity and ocular surface homeostasis.

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“…Epithelial and stromal remodelling following refractive surgery are important indicators for predicting the final clinical and refractive results [14][15][16] . This study aimed at investigating corneal epithelial and stromal remodelling following stromal lenticule addition keratoplasty (SLAK) using a high-resolution, spectral domain, anterior segment OCT (AS-OCT).…”

mentioning

confidence: 99%

Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

Nubile

Salgari

Calienno

et al. 2021

Sci Rep

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The purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.

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Utility of regional epithelial thickness measurements in corneal evaluations

Cited by 55 publications

References 77 publications

<p>Initial Outcomes with Customized Myopic LASIK, Guided by Automated Ray Tracing Optimization: A Novel Technique</p>

<p>Initial Outcomes with Customized Myopic LASIK, Guided by Automated Ray Tracing Optimization: A Novel Technique</p>

Effect of Proparacaine Hydrochloride Eye Drops on the Ocular Surface

Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

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