Utility of renal allograft biopsy: An audit of 80 allograft biopsies

Ms, Uppin; Ak, Prayaga; Kv, Murty

doi:10.4103/0971-4065.109450

Cited by 2 publications

(5 citation statements)

References 5 publications

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“…Our experience with allograft biopsies has been published earlier. [ 10 11 ] The standard triple immunosupression is followed at our centre that includes steroid based therapy, calcineurine inhibitors (Cyclosporine or Tacrolimus) along with azathioprine or mycophenolate mofetil. All biopsies from January 2013 to October 2014 were reviewed.…”

Section: Methodsmentioning

confidence: 99%

Expanding the antibody-mediated component of plasma cell-rich acute rejection: A case series

Ms¹,

Swarnalatha²,

Taduri³

et al. 2016

Indian J Nephrol

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Renal allograft rejection is mediated by T-cells (T-cell mediated rejection) or by donor-specific antibodies (DSAs) (antibody mediated rejection, ABMR). Plasma cell-rich acute rejection (PCAR) is a unique entity due to its peculiar morphology and poor prognostic behavior. All allograft biopsies done at our center from January 2013 to October 2014 were reviewed, and seven were identified with a diagnosis of PCAR with antibody mediated rejection (ABMR). The allograft biopsies were classified as per the Banff 2007 schema. Immunohistochemistry with C4d, SV 40, CD3, CD20, CD138, kappa and lambda light chain was performed. Total 210 allograft biopsies were performed in the study period of which seven biopsies (3.3%) were diagnosed as PCAR with ABMR. All these were late ABMRs (more than 6 months) with median posttransplant duration of 17 months. The allograft biopsy showed features of PCAR along with glomerulitis, peritubular capillaritis, and positive C4d. DSA was positive in six patients. All the patients were treated with standard therapeutic measures of acute cellular rejection (ACR) and ABMR including steroids, plasma exchange, rituximab and intravenous immunoglobulins. All the patients had persistent graft dysfunction or graft loss on follow-up.

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Section: Methodsmentioning

confidence: 99%

Expanding the antibody-mediated component of plasma cell-rich acute rejection: A case series

Ms¹,

Swarnalatha²,

Taduri³

et al. 2016

Indian J Nephrol

Self Cite

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“…Uppin et al ., deserve congratulations for sharing their experience on the utility of renal allograft biopsies in the management of renal transplant patients at their center. [ 1 ] Indeed, this is a timely contribution to the meager literature on this subject from the Indian Subcontinent. We have also previously published our experience on renal allograft biopsy findings in one of the largest studies in the world.…”

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confidence: 94%

“…[1] Indeed, this is a timely contribution to the meager literature on this subject from the Indian Subcontinent. We have also previously published our experience on renal allograft biopsy findings in one of the largest studies in the world.…”

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confidence: 99%

“…[12] Two of their patients did not grow organisms on urine culture. More studies are needed to address this issue in greater detail.…”

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confidence: 99%

“…Another interesting observation, which we also commonly observe in our patients, is the frequency of culture negative acute pyelonephritis. [ 1 2 ] Two of their patients did not grow organisms on urine culture. More studies are needed to address this issue in greater detail.…”

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confidence: 99%

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