Utility of TG/HDL‐c ratio as a predictor of mortality and cardiovascular disease in patients with chronic kidney disease undergoing hemodialysis: A systematic review

Abstract

The triglyceride/high-density cholesterol-lipoprotein (TG/HDL-c) is a biomarker of cardiovascular events and mortality. In hemodialysis patients, the evidence is controversial. A systematic review was carried out in the Medline, Scopus, Embase, Web of Science, and Pubmed databases to identify the relevant cohort studies on cardiovascular events and mortality in hemodialysis patients the role of TG/HDL-c as a risk factor. Four cohort-type studies were evaluated, with a total of 52,579 hemodialysis patients. Three studies conducted in Asian populations and one study in the United States had the highest percentage of the sample (50,673 patients). The elevated TG/HDL-c ratio is associated with better survival, and there is a consistent gradual inverse association between TG/HDL-c and mortality in all analysis subgroups. In the decile categorization of the exposure variable, a 21% decrease in the risk of cardiovascular mortality and a 15% decrease in all-cause mortality in the highest decile compared to the reference group (D10 aHR = 0.79; 95% CI: 0.69-0.91 and D10 aHR = 0.85; 95%CI: 0.78-0.92). Our results show that the TG/HDL-c ratio is a protective factor for cardiovascular outcomes and mortality in the American population and a risk factor for them in the population from Asia.

Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China

“…Previous studies have demonstrated the correlation of lipid parameters including TG, TC, HDL-C, LDL-C, LDL-C/HDL-C, non-HDL-C, TC/HDL-C with pre-DM and DM [ 28 – 31 ]. Among them, TG and HDL-C have been considered important risk factors for developing CVD in Asians [ 32 , 33 ]. The potential clinical significance of TG/HDL-C has been widely explored as a product of these two.…”

Association between the triglyceride to high-density lipoprotein cholesterol ratio and mortality in Chinese maintenance haemodialysis patients: a retrospective cohort study

“…A large retrospective analysis of 50 673 American HD patients found that the TG/HDL-C ratio is a protective factor for mortality 36. Gonzáles-Rubianes et al pointed out that three studies focused on the Asian HD population showed that a higher TG/HDL-C ratio was associated with higher mortality 37. A U-shaped relationship between atherogenic index of plasma (AIP, the logarithmic ratio of TG/HDL-C) and all-cause death in dialysis populations was discovered in a Korean study, with both the greatest and lowest AIP groups being related to high mortality 38.…”

“…36 Gonzáles-Rubianes et al pointed out that three studies focused on the Asian HD population showed that a higher TG/HDL-C ratio was associated with higher mortality. 37 A U-shaped relationship between atherogenic index of plasma (AIP, the logarithmic ratio of TG/ HDL-C) and all-cause death in dialysis populations was discovered in a Korean study, with both the greatest and lowest AIP groups being related to high mortality. 38 A study focused on Taiwan patients reported that high TG/ HDL-C levels were related to worse CV events and death in dialysis populations, but the association did not exist in diabetic dialysis patients.…”

Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China

“…Previous studies have demonstrated the correlation of lipid parameters including TG, TC, HDL-C, LDL-C, LDL-C/HDL-C, non-HDL-C, TC/HDL-C with pre-DM and DM [27][28][29][30]. Among them, TG and HDL-C have been considered as important risk factors for the development of cardiovascular disease (CVD) in Asians [31][32].…”