Utility of serum amyloid A as a potential prognostic biomarker of acute primary basal ganglia hemorrhage

Huangfu, Xue-Qin; Wang, Linguo; Le, Zhou-Di; Bo, Tao

doi:10.1016/j.cca.2020.02.022

Cited by 16 publications

(12 citation statements)

References 24 publications

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“…Amyloid A (SAA) is a highly sensitive protein produced by macrophages and fibroblasts activated in the liver in the acute phase of the disease [ 2 ]. Studies have shown that SAA rises sharply in the early phase of inflammatory response, which is considered to be involved in the process of arteriosclerosis in cerebrovascular diseases and is critical for the prognosis of cerebral infarction and other diseases [ 3 ]. Homocysteine (Hcy), a sulfur-containing amino acid mainly produced by red blood cells, is involved in the secondary damage of acute cerebral hemorrhage and is a key independent risk factor for cardiovascular and cerebrovascular diseases [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation and Prognostic Action of SAA, Hcy, and BNP Levels with the Condition of Patients with Spontaneous Intracerebral Hemorrhage

Wang

Li³

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the correlation of serum amyloid A (SAA), homocysteine (Hcy), and plasma B-type brain natriuretic peptide (BNP) levels in patients with spontaneous intracerebral hemorrhage (SICH) and their predictive value for the status and prognosis of SICH patients. Methods. 82 SICH patients admitted to our hospital from March 2017 to March 2020 were selected. According to the Glasgow coma scale (GCS) score, the patients were divided into GCS > 8 group (n = 44) and the GCS ≤ 8 group (n = 38). Based on the bleeding volume, the patients were divided into the massive bleeding group (>30 ml) (n = 21), the moderate bleeding group (10∼30 ml) (n = 28), and the small bleeding group (<10 ml) (n = 33). Based on the prognostic status of patients after 28 days of admission, they were divided into the survival group (n = 64) and the death group (n = 18). Serum SAA, Hcy, and plasma BNP levels of patients in different groups were compared, and the correlation between serum SAA, Hcy and plasma BNP levels with GCS score, cerebral hemorrhage, and the prognostic value of patients was analyzed. Results. Serum SAA, Hcy, and plasma BNP levels in patients with GCS ≤ 8 groups were higher than those in GCS > 8 groups ( P < 0.05 ). Serum SAA, Hcy, and plasma BNP levels of patients in the massive bleeding group were higher than those in the moderate and small bleeding groups. Besides, the level of serum SAA, Hcy, and plasma BNP in the moderate bleeding group was higher than that in the small bleeding group ( P < 0.05 ). Serum SAA, Hcy and plasma BNP levels of patients were negatively correlated with GCS scores but positively correlated with bleeding volume ( P < 0.05 ). The levels of serum SAA, Hcy and plasma BNP in dead patients were higher than those in the survival patients ( P < 0.05 ). The combined prediction of serum SAA, Hcy, and plasma BNP for the prognosis of SICH patients was 0.910 (95% CI: 0.984∼0.837), which was higher than the serum SAA, Hcy, and plasma BNP alone predicted AUC 0.679 (95% CI: 0.564∼0.795), 0.720 (95% CI: 0.603∼0.836), and 0.726 (95% CI: 0.616∼0.849). Conclusion. The levels of serum SAA, Hcy, and plasma BNP have a correlation with the severity and prognosis of patients with SICH, which is a feasible index for judging the prognosis of SICH. The levels of serum SAA, Hcy, and plasma BNP are conducive to timely judgment of the progression and prognosis of SICH patients.

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Section: Introductionmentioning

confidence: 99%

Correlation and Prognostic Action of SAA, Hcy, and BNP Levels with the Condition of Patients with Spontaneous Intracerebral Hemorrhage

Wang

Li³

2022

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, minimally invasive puncture treatment can decrease the fatality rate to 33.3% (7/21) 40 . The hsCRP is an indication of inflammation, a prospective, observational study from Huangfu XQ found statistically that high a level of hsCRP appeared to be an independent predictor for 90-day death, overall survival, and poor outcome in acute primary BGH 41 .…”

Section: Discussionmentioning

confidence: 98%

Machine-learning-based risk stratification for probability of dying in patients with basal ganglia hemorrhage

Guo

Lei

Gao

et al. 2022

Sci Rep

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To confirm whether machine learning algorithms (MLA) can achieve an effective risk stratification of dying within 7 days after basal ganglia hemorrhage (BGH). We collected patients with BGH admitted to Sichuan Provincial People’s Hospital between August 2005 and August 2021. We developed standard ML-supervised models and fusion models to assess the prognostic risk of patients with BGH and compared them with the classical logistic regression model. We also use the SHAP algorithm to provide clinical interpretability. 1383 patients with BGH were included and divided into the conservative treatment group (CTG) and surgical treatment group (STG). In CTG, the Stack model has the highest sensitivity (78.5%). In STG, Weight-Stack model achieves 58.6% sensitivity and 85.1% specificity, and XGBoost achieves 61.4% sensitivity and 82.4% specificity. The SHAP algorithm shows that the predicted preferred characteristics of the CTG are consciousness, hemorrhage volume, prehospital time, break into ventricles, brain herniation, intraoperative blood loss, and hsCRP were also added to the STG. XGBoost, Stack, and Weight-Stack models combined with easily available clinical data enable risk stratification of BGH patients with high performance. These ML classifiers could assist clinicians and families to identify risk states timely when emergency admission and offer medical care and nursing information.

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“…APPs are useful indicators of inflammation across species [48], and are increasingly used in veterinary medicine [57][58][59]. As well as being indicative of existing pathology, concentrations can be used as indicators of disease etiology [60,61], severity [58,62,63], and prognosis PLOS ONE [59,64,65]. A previous study by Stanton and colleagues [29] reported elevated SAA during EEHV1 viremia in Asian elephants, and in samples with greater than 10,000 vge/ml.…”

Section: Discussionmentioning

confidence: 99%

Patterns of serum immune biomarkers during elephant endotheliotropic herpesvirus viremia in Asian and African elephants

et al. 2021

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Hemorrhagic disease (HD) caused by a group of elephant endotheliotropic herpesviruses (EEHV) is one of the leading causes of death for young elephants in human care. These viruses are widespread and typically persist latently in adult elephants with no negative effects; however, in juvenile Asian and more recently young African elephants, the onset of disease can be rapid and the mortality rate high. Measuring biomarkers associated with the immune response could be beneficial to understanding underlying disease processes, as well as the management of infection and HD. The goal of this study was to measure acute phase proteins and cytokines in serum collected from elephants infected with EEHV (13 Asian and 1 African) and compare concentrations according to presence, severity and outcome of disease. Serum amyloid A (SAA) and haptoglobin (HP) were higher in elephants with EEHV viremia than those without; concentrations increased with increasing viral load, and were higher in fatal cases compared to those that survived. In Asian elephants, SAA was also higher during EEHV1 viremia compared to EEHV5. Cytokine concentrations were typically low, and no statistical differences existed between groups. However, in individuals with detectable levels, longitudinal profiles indicated changes in tumor necrosis factor alpha (TNF-α) and interleukin-2 (IL-2) that may reflect an immune response to EEHV infection. However, the overall low concentrations detected using previously validated assays do not support the presence of a ‘cytokine storm’ and suggest more work is needed to understand if sub-optimal immune responses could be involved in disease progression. These results highlight the potential benefit of measuring circulating biomarker concentrations, such as APPs and cytokines, to improve our understanding of EEHV viremia and HD, assist with monitoring the progression of disease and determining the impact of interventions.

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Utility of serum amyloid A as a potential prognostic biomarker of acute primary basal ganglia hemorrhage

Cited by 16 publications

References 24 publications

Correlation and Prognostic Action of SAA, Hcy, and BNP Levels with the Condition of Patients with Spontaneous Intracerebral Hemorrhage

Correlation and Prognostic Action of SAA, Hcy, and BNP Levels with the Condition of Patients with Spontaneous Intracerebral Hemorrhage

Machine-learning-based risk stratification for probability of dying in patients with basal ganglia hemorrhage

Patterns of serum immune biomarkers during elephant endotheliotropic herpesvirus viremia in Asian and African elephants

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